THE EFFECT OF MIROESTROL ON VAGINAL CORNIFICATION, PITUITARY FUNCTION AND PREGNANCY IN THE RAT

1961 ◽  
Vol 22 (3) ◽  
pp. 293-302 ◽  
Author(s):  
H. E. H. JONES ◽  
H. B. WAYNFORTH ◽  
G. S. POPE
Keyword(s):  
Oral Administration ◽  
Adult Male ◽  
Vaginal Epithelium ◽  
Pituitary Function ◽  
Ovariectomized Rat ◽  
Male Rat ◽  
Female Rat ◽  
Adult Male Rat ◽  
Mated Female

SUMMARY 1. The effectiveness of miroestrol in causing cornification of the vagina of the ovariectomized rat, inhibiting pituitary activity of the adult male rat and preventing pregnancy in the mated female rat has been compared with that of hexoestrol and stilboestrol when each oestrogen is administered either subcutaneously or orally. 2. Inhibition of pituitary function and prevention of pregnancy by these substances are directly related to their activity in producing cornification of the vaginal epithelium. Only large doses of oestrogen produce the first two responses fully. 3. When administered subcutaneously miroestrol has about 0·3 of the potency of stilboestrol and 0·25 of that of hexoestrol in each response studied. By oral administration it is 0·8 as potent as stilboestrol and more potent than hexoestrol. Since the potency of miroestrol compared with a given oestrogen administered in the same way is of the same order in each response, it is concluded that these substances are only capable of inhibiting the function of the pituitary and of preventing pregnancy because of their oestrogenic activity.

Effects of Insulin-Like Growth Factors on Adult Male Rat Pituitary Function in Tissue Culture*

Endocrinology ◽  
1984 ◽  
Vol 115 (4) ◽  
pp. 1568-1576 ◽  
Author(s):  
CYNTHIA G. GOODYER ◽  
LUCIE DE STEPHANO ◽  
HARVEY J. GUYDA ◽  
BARRY I. POSNER
Keyword(s):  
Tissue Culture ◽  
Growth Factors ◽  
Adult Male ◽  
Pituitary Function ◽  
Male Rat ◽  
Rat Pituitary ◽  
Adult Male Rat ◽  
Insulin Like Growth Factors

scholarly journals Effects of sex hormones on enzymic esterification of 2-(N-hydroxyacetamido)-fluorene by rat liver cytosol

1970 ◽  
Vol 120 (2) ◽  
pp. 409-416 ◽  
Author(s):  
Prabhakar D. Lotlikar
Keyword(s):  
Rat Liver ◽  
Adult Male ◽  
Male Rat ◽  
Female Rat ◽  
Liver Cytosol ◽  
Adult Male Rat ◽  
Derivatives Of ◽  
Sex And Age Differences ◽  
Rat Liver Cytosol

1. Enzymic esterifications of 2-(N-hydroxyacetamido)fluorene and several other hydroxamic acids by liver cytosol were studied. Determination of 2-acetamido-3-methylthiofluorene was used for the assay. 2. With rat liver cytosol, requirement for ATP, Mg2+ and SO42− suggested formation of phosphate and sulphate esters of 2-(N-hydroxyacetamido)fluorene. 3. Rats showed sex and age differences in their activity. Liver from adult male rat was at least twice as active as liver from adult female rat. No such sex differences were found in mice, hamsters and guinea pigs. 4. Administration of testosterone (300μg/day) subcutaneously for 8 days increased the activity in the female rat by 100%, whereas diethylstilboestrol (100μg/day) had no effect. In the male rat diethylstilboestrol treatment decreased the activity by 60%, whereas testosterone pretreatment was without any effect. 5. Among various endocrine ablations such as adrenalectomy, castration, adrenalectomy–castration and hypophysectomy in the adult male rat, hypophysectomy was found to be the most effective in decreasing the activity of the liver to about 50% of control values. 6. Like 2-(N-hydroxyacetamido)fluorene, various other N-hydroxy derivatives of 2-acetamido-7-fluorofluorene, 2-acetamidophenanthrene, 4-acetamidobiphenyl and 4-acetamidostilbene were also shown to be esterified to different extents by rat liver cytosol.

scholarly journals The Anti-Reproductive Effects of Long Term Oral Administration of Cadmium on the Adult Male Rat

1979 ◽  
Vol 2 (1-6) ◽  
pp. 150-161 ◽  
Author(s):  
Barbara Zielinska-Psuja ◽  
A. Lukaszyk ◽  
W. Senczuk
Keyword(s):  
Oral Administration ◽  
Adult Male ◽  
Male Rat ◽  
Reproductive Effects ◽  
Adult Male Rat

scholarly journals Maternal tobacco smoke increased visceral adiposity and serum corticosterone levels in adult male rat offspring

2014 ◽  
Vol 76 (1) ◽  
pp. 17-23 ◽  
Author(s):  
Erin K. Zinkhan ◽  
Brook Y. Lang ◽  
Baifeng Yu ◽  
Yan Wang ◽  
Chengshe Jiang ◽  
...  
Keyword(s):  
Adult Male ◽  
Tobacco Smoke ◽  
Visceral Adiposity ◽  
Male Rat ◽  
Serum Corticosterone ◽  
Rat Offspring ◽  
Adult Male Rat

15-Day intact adult male rat assay with alpha-cypermethrin

2016 ◽  
Vol 258 ◽  
pp. S308-S309 ◽  
Author(s):  
M. Kemény ◽  
H.A. Marxfeld ◽  
R. Buesen ◽  
A. Chukwudebe ◽  
B. Van Ravenzwaay ◽  
...  
Keyword(s):  
Adult Male ◽  
Male Rat ◽  
Adult Male Rat

scholarly journals Synergistic effects of dehydroepiandrosterone and fluoxetine on proliferation of progenitor cells in the dentate gyrus of the adult male rat

Neuroscience ◽  
2009 ◽  
Vol 158 (4) ◽  
pp. 1644-1651 ◽  
Author(s):  
S.B. Pinnock ◽  
S.E. Lazic ◽  
H.T. Wong ◽  
I.H.W. Wong ◽  
J. Herbert
Keyword(s):  
Dentate Gyrus ◽  
Progenitor Cells ◽  
Adult Male ◽  
Synergistic Effects ◽  
Male Rat ◽  
Adult Male Rat

Prenatal fluoxetine impairs non-hippocampal but not hippocampal memory in adult male rat offspring

2021 ◽  
pp. 108751
Author(s):  
Rodrigo Moraga-Amaro ◽  
Raul Díaz-Galarce ◽  
Juan P. Donoso-Ramos ◽  
Valentina Ugalde ◽  
Sergio Linsambarth ◽  
...  
Keyword(s):  
Adult Male ◽  
Male Rat ◽  
Rat Offspring ◽  
Adult Male Rat

scholarly journals Boswellia serrata gum resin aqueous extract upregulatesBDNF but not CREB expression in adult male rat hippocampus

2016 ◽  
Vol 46 ◽  
pp. 1573-1578 ◽  
Author(s):  
Mohammad KHALAJ-KONDORI ◽  
Farzaneh SADEGHI ◽  
Mohammad Ali HOSSEINPOURFEIZI ◽  
Farzam SHAIKHZADEH-HESARI ◽  
Aylar NAKHLBAND ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Adult Male ◽  
Rat Hippocampus ◽  
Male Rat ◽  
Boswellia Serrata ◽  
Adult Male Rat
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