Recent Trends in Drug Interaction Studies based on Drug Metabolism

Yakhak Hoeji ◽  
2020 ◽  
Vol 64 (1) ◽  
pp. 8-20
Author(s):  
Jinseok Lee ◽  
Sung-Hoon Ahn
Keyword(s):  
Drug Interaction ◽  
Drug Metabolism ◽  
Interaction Studies ◽  
Recent Trends

Drug interaction studies of esomeprazole with amoxicillin and clarithromycin

2001 ◽  
Vol 120 (5) ◽  
pp. A581-A581
Author(s):  
T ANDERSSON ◽  
L ASTRAZENECA ◽  
K ROHSS ◽  
M HASSANALIN
Keyword(s):  
Drug Interaction ◽  
Interaction Studies

Lurasidone drug-drug interaction studies: a comprehensive review

2014 ◽  
Vol 29 (3) ◽  
Author(s):  
Yu-Yuan Chiu ◽  
Larry Ereshefsky ◽  
Sheldon H. Preskorn ◽  
Nagaraju Poola ◽  
Antony Loebel
Keyword(s):  
Drug Interaction ◽  
Comprehensive Review ◽  
Interaction Studies ◽  
Drug Drug Interaction

Inhibition of Hepatic Microsomal Drug Metabolism by the Hydrazines Ro 4-4602, MK 486, and Procarbazine Hydrochloride

1972 ◽  
Vol 50 (7) ◽  
pp. 721-724 ◽  
Author(s):  
Norman R. Bade ◽  
Stuart M. MacLeod ◽  
Kenneth W. Renton
Keyword(s):  
Drug Interaction ◽  
Drug Metabolism ◽  
Sleeping Time ◽  
Hydrazine Derivatives ◽  
Significant Drug Interaction ◽  
Microsomal Drug Metabolism ◽  
Clinically Significant ◽  
Hepatic Biotransformation

Preliminary experiments were undertaken to examine the effect of three hydrazine derivatives, viz. Ro 4-4602, MK 486, and procarbazine hydrochloride, on hepatic microsomal drug metabolism in rats. All three compounds when given as pretreatment significantly prolonged pentobarbital sleeping time. In vitro, the hepatic microsomal N-demethylation of aminopyrine was inhibited. It is concluded that all three drugs are possible sources of clinically significant drug interaction when administered in combination with other agents which undergo hepatic biotransformation.

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