scholarly journals Pseudoexfoliation syndrome and meibomian gland dysfunction

2016 ◽  
Vol 9 (4) ◽  
pp. 52-57
Author(s):  
Vitaly V Potemkin ◽  
Elena V Ageeva
Keyword(s):  
Connective Tissue ◽  
Prospective Study ◽  
Meibomian Gland ◽  
Meibomian Gland Dysfunction ◽  
Pseudoexfoliation Syndrome ◽  
Related Disease ◽  
Age Related ◽  
Study Results

Pseudoexfoliation syndrome (PEX) is a relatively widespread generalized age-related disease of connective tissue. The condition of meibomians gland in patients with PEX not evaluated yet. Purpose. To evaluate the condition of meibomians glands in PEX. Methods. 132 eyes of 66 patients with PEX syndrome and 128 eyes of 64 patients without it were enrolled in the prospective study. Results. Signs of atonic changes of meibomians glands were similar in both groups. Meibomians gland dysfunction was significantly more expressed in patients with PEX (p < 0,05).

Influence of Meibomian Gland Dysfunction and Friction-Related Disease on the Severity of Dry Eye

Ophthalmology ◽  
2018 ◽  
Vol 125 (8) ◽  
pp. 1181-1188 ◽  
Author(s):  
Chi Hoang Viet Vu ◽  
Motoko Kawashima ◽  
Masakazu Yamada ◽  
Kazuhisa Suwaki ◽  
Miki Uchino ◽  
...  
Keyword(s):  
Dry Eye ◽  
Meibomian Gland ◽  
Meibomian Gland Dysfunction ◽  
Related Disease

scholarly journals Periplocin ameliorates mouse age-related meibomian gland dysfunction through up-regulation of Na/K-ATPase via SRC pathway

2022 ◽  
Vol 146 ◽  
pp. 112487
Author(s):  
Huifeng Wang ◽  
Zongzheng Zou ◽  
Luqin Wan ◽  
Junfa Xue ◽  
Chen Chen ◽  
...  
Keyword(s):  
Meibomian Gland ◽  
Meibomian Gland Dysfunction ◽  
Age Related ◽  
Src Pathway

scholarly journals Ocular pulse amplitude in patients with pseudoexfoliation syndrome

2016 ◽  
Vol 15 (4) ◽  
pp. 68-74
Author(s):  
V. V. Potemkin ◽  
E. V. Ageeva
Keyword(s):  
Perfusion Pressure ◽  
Pulse Amplitude ◽  
Ocular Blood Flow ◽  
Pseudoexfoliation Syndrome ◽  
Extracellular Material ◽  
Ocular Pulse Amplitude ◽  
Related Disease ◽  
Age Related ◽  
Ocular Pulse ◽  
Amplitude Decrease

Pseudoexfoliation syndrome (PEX) is a relatively widespread generalized age-related disease, in which abnormal fibrillar extracellular material is produced and accumulates in many tissues. It seems reasonable to evaluate ocular pulse amplitude in patients with PEX. Purpose. To evaluate ocular pulse amplitude in patients with PEX. Methods. 460 eyes of 230 patients were enrolled in the prospective study. We evaluated ocular pulse amplitude and perfusion pressure. Results. Difference in perfusion pressure between groups was not significant. Ocular pulse amplitude was significantly lower in patients with PEX. Conclusion. Ocular pulse amplitude decrease indicates damage of ocular blood flow.

scholarly journals Absence of ductal hyper-keratinization in Mouse age-related meibomian gland dysfunction (ARMGD)

Aging ◽  
2013 ◽  
Vol 5 (11) ◽  
pp. 825-834 ◽  
Author(s):  
Geraint J. Parfitt ◽  
Yilu Xie ◽  
Mikhail Geyfman ◽  
Donald J. Brown ◽  
James V. Jester
Keyword(s):  
Meibomian Gland ◽  
Meibomian Gland Dysfunction ◽  
Age Related

scholarly journals Efficacy of Topical Cyclosporine 0.05% in the Treatment of Meibomian Gland Dysfunction: A Hospital Based Prospective Study

2019 ◽  
Vol 2 (1) ◽  
pp. 40-46
Author(s):  
Poonam Shrestha ◽  
Khem Raj Kaini ◽  
Tirtha Man Shrestha
Keyword(s):  
Prospective Study ◽  
Signs And Symptoms ◽  
Meibomian Gland ◽  
Meibomian Gland Dysfunction ◽  
Hospital Department ◽  
Ocular Symptoms ◽  
Dexamethasone Group ◽  
Department Of Ophthalmology ◽  
Group A ◽  
Group B

Purpose:  To compare the efficacy of topical cyclosporine 0.05% with tobramycin 0.3% and dexamethasone 0.1% eye drop in reducing signs and symptoms of Meibomian gland dysfunction. Design:  A hospital based randomized prospective study conducted at Manipal Teaching Hospital, Department of Ophthalmology, Pokhara, over a period of 18 months, from January 2012 to June 2013. Methods:  30 patients who were diagnosed as Meibomian gland dysfunction were recruited and randomly assigned into two groups i.e. Group- A received Cyclosporine 0.05% and Group-B received Tobramycin/dexamethasone. Before starting treatment ocular symptoms were recorded with help of OSDI score. All patients underwent examinations including visual acuity, intraocular pressure, Schirmer’s test, Tear break up time, Lissamine staining, slit lamp examination for lid telangiectasia, open and clogged meibomian glands, inclusions and meibomian secretion quality. Result: OSDI score significantly improved in cyclosporine group than in tobramycin/dexamethasone group. Other objective measurements like Schirmer value, Lissamine staining, meibomian secretion quality, number of lid telangiectasia and clogged glands improved in Cyclosporine group. Conclusion:  The present hospital based study noted that Meibomian gland dysfunction can be more effectively treated with cyclosporine than tobramycin/dexamethasone.

scholarly journals Pseudoexfoliation syndrome and ocular adnexa

2016 ◽  
Vol 9 (3) ◽  
pp. 15-21 ◽  
Author(s):  
Vitaly V. Potemkin ◽  
Vyacheslav V. Rakhmanov ◽  
Elena V. Ageeva ◽  
Aisa S. Alchinova ◽  
Elena V. Meshveliani
Keyword(s):  
Muscle Tone ◽  
Lower Eyelid ◽  
Levator Muscle ◽  
Pseudoexfoliation Syndrome ◽  
Orbicularis Muscle ◽  
Upper Eyelid ◽  
Ocular Adnexa ◽  
Related Disease ◽  
Age Related ◽  
And Function

Pseudoexfoliation syndrome (PEX) is a relatively widespread generalized age-related disease of connective tissue. It seems reasonable to evaluate the condition of ocular adnexa in patients with PEX. Purpose. To evaluate the condition of ocular adnexal tissue in PEX. Methods. 132 eyes of 66 patients with PEX syndrome and 128 eyes of 64 patients without it were enrolled in the prospective study. We evaluated function of upper eyelid levator muscle, lower eyelid retractors, horizontal lid laxity (HLL), canthal integrity, degree of retractors disinsertion and tone of orbicularis muscle. Results. HLL, degree of retractors disinsertion, laxity of medial canthal tendon were statistically significantly more expressed in patients with PEX (p < 0,05). The tone of orbicularis muscle and function of lower eyelid retractors were statistically lower in patients with PEX (p < 0,05). The function of eyelids levator muscle, tone of lateral canthal tendon and degree of ptosis were similar in both groups. Conclusion. Signs of atonic changes of ocular adnexa are relatively more common in patients with PEX (p < 0,05).

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