scholarly journals Pseudoexfoliation syndrome and ocular adnexa

2016 ◽  
Vol 9 (3) ◽  
pp. 15-21 ◽  
Author(s):  
Vitaly V. Potemkin ◽  
Vyacheslav V. Rakhmanov ◽  
Elena V. Ageeva ◽  
Aisa S. Alchinova ◽  
Elena V. Meshveliani
Keyword(s):  
Muscle Tone ◽  
Lower Eyelid ◽  
Levator Muscle ◽  
Pseudoexfoliation Syndrome ◽  
Orbicularis Muscle ◽  
Upper Eyelid ◽  
Ocular Adnexa ◽  
Related Disease ◽  
Age Related ◽  
And Function

Pseudoexfoliation syndrome (PEX) is a relatively widespread generalized age-related disease of connective tissue. It seems reasonable to evaluate the condition of ocular adnexa in patients with PEX. Purpose. To evaluate the condition of ocular adnexal tissue in PEX. Methods. 132 eyes of 66 patients with PEX syndrome and 128 eyes of 64 patients without it were enrolled in the prospective study. We evaluated function of upper eyelid levator muscle, lower eyelid retractors, horizontal lid laxity (HLL), canthal integrity, degree of retractors disinsertion and tone of orbicularis muscle. Results. HLL, degree of retractors disinsertion, laxity of medial canthal tendon were statistically significantly more expressed in patients with PEX (p < 0,05). The tone of orbicularis muscle and function of lower eyelid retractors were statistically lower in patients with PEX (p < 0,05). The function of eyelids levator muscle, tone of lateral canthal tendon and degree of ptosis were similar in both groups. Conclusion. Signs of atonic changes of ocular adnexa are relatively more common in patients with PEX (p < 0,05).

scholarly journals Aesthetic Medicine

2019 ◽  
Vol 4 (5) ◽  
Keyword(s):  
Muscle Tone ◽  
Upper Eyelid ◽  
Aesthetic Medicine ◽  
Age Related ◽  
The Face ◽  
Injection Techniques ◽  
Physiological Type ◽  
Age Related Changes ◽  
Morph Type

GalynaViktorovnaKhrushch plastic surgeon, maxillofacial surgeon, international candidat ASPS, Periorbital area is worthily considered as one of the most complicated regions in terms of correction of the age-related changes using injection techniques of medical aesthetics. According to the classification of I.I. Kolgunenko Russian (1974), tired morph type of age-related changes which is the most physiological type of aging, incorporates changes mainly focused in the middle third of the face, including in the periorbital area. These changes include the formation of grooves (tear trough, palpebromalar groove, nasojugal groove) (Figure 1), dark under-eye circles, mimic wrinkles formation, fat compartment displacement, change in mimic muscle tone, stretching of ligamentous structures, overhang of the upper eyelid.

Management of Entropion and Trichiasis

2011 ◽  
Author(s):  
David H. Verity ◽  
Geoffrey E. Rose
Keyword(s):  
Ocular Surface ◽  
Lower Eyelid ◽  
Complete Loss ◽  
Secondary Effects ◽  
Orbicularis Muscle ◽  
Eyelid Margin ◽  
Ocular Irritation ◽  
Age Related ◽  
Causative Factors ◽  
Gentle Traction

Entropion is a posterior rotation of the upper or lower lid margin against the globe; the causes include involutional changes within the eyelid tissues or cicatricial shortening of the posterior lamella of the eyelid. Congenital lower lid entropion is rare and results from an excess of skin and orbicularis oculi muscle being only loosely attached to the eyelid retractors. The symptoms of entropion—which include ocular irritation, lid spasm, pain, redness, and watering—are worse in the presence of a keratinized lid margin (occurring in cicatricial disease) and where the ocular surface is compromised. Discomfort may lead to secondary blepharospasm, which exacerbates the entropion by causing the preseptal part of the orbicularis muscle to override the pretarsal component. The eyelids and globe should be examined to identify underlying causative factors—in particular the degree and position of tissue laxity, the position of the eyelid margin and lashes, and the thickness of the tarsus. Any secondary effects of entropion, both within the lid and on the ocular surface, should also be noted. 7-1-1 Tissue Laxity. Aging of collagen and the force of gravity leads to eyelid laxity and an excess of tissues, particularly the anterior lamella of the lid. Stretching of the orbicularis muscle and canthal tendons results in horizontal laxity, and eyelid stability is further compromised by enophthalmos due to age-related fat atrophy. Where there is a relative dissociation between the anterior and posterior lamellae, the preseptal orbicularis muscle overrides the pretarsal muscle, leading to eyelid inversion, and this effect is exacerbated both by laxity of the lower lid retractors and age-related tarsal atrophy. Tissue laxity in the absence of orbicularis overriding tends to cause ectropion; with complete loss of retractor action, this can result in complete eversion of the tarsus (“shelf ectropion”). Horizontal laxity of the eyelid tissues is assessed by grasping the lid skin and applying gentle traction in the appropriate direction. The overall horizontal laxity is judged by the extent to which the eyelid can be parted from the globe—greater than about 6 mm is abnormal for a lower eyelid—and by the speed with which the retracted lid returns to the surface of the globe (the “spring-back” test).

scholarly journals Metabolism, Genomics, and DNA Repair in the Mouse Aging Liver

2011 ◽  
Vol 2011 ◽  
pp. 1-15 ◽  
Author(s):  
Michel Lebel ◽  
Nadja C. de Souza-Pinto ◽  
Vilhelm A. Bohr
Keyword(s):  
Dna Repair ◽  
Point Mutations ◽  
Dna Lesions ◽  
Model Systems ◽  
Rodent Models ◽  
Waste Products ◽  
Related Disease ◽  
Age Related ◽  
Significant Impairment ◽  
And Function

The liver plays a pivotal role in the metabolism of nutrients, drugs, hormones, and metabolic waste products, thereby maintaining body homeostasis. The liver undergoes substantial changes in structure and function within old age. Such changes are associated with significant impairment of many hepatic metabolic and detoxification activities, with implications for systemic aging and age-related disease. It has become clear, using rodent models as biological tools, that genetic instability in the form of gross DNA rearrangements or point mutations accumulate in the liver with age. DNA lesions, such as oxidized bases or persistent breaks, increase with age and correlate well with the presence of senescent hepatocytes. The level of DNA damage and/or mutation can be affected by changes in carcinogen activation, decreased ability to repair DNA, or a combination of these factors. This paper covers some of the DNA repair pathways affecting liver homeostasis with age using rodents as model systems.

scholarly journals Pseudoexfoliation syndrome and meibomian gland dysfunction

2016 ◽  
Vol 9 (4) ◽  
pp. 52-57
Author(s):  
Vitaly V Potemkin ◽  
Elena V Ageeva
Keyword(s):  
Connective Tissue ◽  
Prospective Study ◽  
Meibomian Gland ◽  
Meibomian Gland Dysfunction ◽  
Pseudoexfoliation Syndrome ◽  
Related Disease ◽  
Age Related ◽  
Study Results

Pseudoexfoliation syndrome (PEX) is a relatively widespread generalized age-related disease of connective tissue. The condition of meibomians gland in patients with PEX not evaluated yet. Purpose. To evaluate the condition of meibomians glands in PEX. Methods. 132 eyes of 66 patients with PEX syndrome and 128 eyes of 64 patients without it were enrolled in the prospective study. Results. Signs of atonic changes of meibomians glands were similar in both groups. Meibomians gland dysfunction was significantly more expressed in patients with PEX (p < 0,05).

scholarly journals Puzzles in modern biology. III. Two kinds of causality in age-related disease

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 2533 ◽  
Author(s):  
Steven A. Frank
Keyword(s):  
Physiological Function ◽  
Age Of Onset ◽  
Disease Onset ◽  
Physiological Role ◽  
Rate Function ◽  
Causal Factor ◽  
Modern Biology ◽  
Related Disease ◽  
Age Related ◽  
And Function

The two primary causal dimensions of age-related disease are rate and function. Change in rate of disease development shifts the age of onset. Change in physiological function provides necessary steps in disease progression. A causal factor may alter the rate of physiological change, but that causal factor itself may have no direct physiological role. Alternatively, a causal factor may provide a necessary physiological function, but that causal factor itself may not alter the rate of disease onset. The rate-function duality provides the basis for solving puzzles of age-related disease. Causal factors of cancer illustrate the duality between rate processes of discovery, such as somatic mutation, and necessary physiological functions, such as invasive penetration across tissue barriers. Examples from cancer suggest general principles of age-related disease.

scholarly journals Ocular pulse amplitude in patients with pseudoexfoliation syndrome

2016 ◽  
Vol 15 (4) ◽  
pp. 68-74
Author(s):  
V. V. Potemkin ◽  
E. V. Ageeva
Keyword(s):  
Perfusion Pressure ◽  
Pulse Amplitude ◽  
Ocular Blood Flow ◽  
Pseudoexfoliation Syndrome ◽  
Extracellular Material ◽  
Ocular Pulse Amplitude ◽  
Related Disease ◽  
Age Related ◽  
Ocular Pulse ◽  
Amplitude Decrease

Pseudoexfoliation syndrome (PEX) is a relatively widespread generalized age-related disease, in which abnormal fibrillar extracellular material is produced and accumulates in many tissues. It seems reasonable to evaluate ocular pulse amplitude in patients with PEX. Purpose. To evaluate ocular pulse amplitude in patients with PEX. Methods. 460 eyes of 230 patients were enrolled in the prospective study. We evaluated ocular pulse amplitude and perfusion pressure. Results. Difference in perfusion pressure between groups was not significant. Ocular pulse amplitude was significantly lower in patients with PEX. Conclusion. Ocular pulse amplitude decrease indicates damage of ocular blood flow.

scholarly journals Puzzles in modern biology. III.Two kinds of causality in age-related disease

F1000Research ◽  
2017 ◽  
Vol 5 ◽  
pp. 2533
Author(s):  
Steven A. Frank
Keyword(s):  
Physiological Function ◽  
Age Of Onset ◽  
Disease Onset ◽  
Physiological Role ◽  
Rate Function ◽  
Causal Factor ◽  
Modern Biology ◽  
Related Disease ◽  
Age Related ◽  
And Function

The two primary causal dimensions of age-related disease are rate and function. Change in rate of disease development shifts the age of onset. Change in physiological function provides necessary steps in disease progression. A causal factor may alter the rate of physiological change, but that causal factor itself may have no direct physiological role. Alternatively, a causal factor may provide a necessary physiological function, but that causal factor itself may not alter the rate of disease onset. The rate-function duality provides the basis for solving puzzles of age-related disease. Causal factors of cancer illustrate the duality between rate processes of discovery, such as somatic mutation, and necessary physiological functions, such as invasive penetration across tissue barriers. Examples from cancer suggest general principles of age-related disease.

scholarly journals The Role of Osteokines in Sarcopenia: Therapeutic Directions and Application Prospects

2021 ◽  
Vol 9 ◽  
Author(s):  
Wenhao Lu ◽  
Wenfeng Xiao ◽  
Wenqing Xie ◽  
Xin Fu ◽  
Linyuan Pan ◽  
...  
Keyword(s):  
The Elderly ◽  
Research Progress ◽  
Mechanical Coupling ◽  
Related Disease ◽  
Major Threat ◽  
Age Related ◽  
Endocrine Organs ◽  
And Function ◽  
Fgf 23

Sarcopenia is an age-related disease in which muscle mass, strength and function may decline with age or can be secondary to cachexia or malnutrition and can lead to weakness, falls and even death. With the increase in life expectancy, sarcopenia has become a major threat to the health of the elderly. Currently, our understanding of bone-muscle interactions is not limited to their mechanical coupling. Bone and muscle have been identified as secretory endocrine organs, and their interaction may affect the function of each. Both muscle-derived factors and osteokines can play a role in regulating muscle and bone metabolism via autocrine, paracrine and endocrine mechanisms. Herein, we comprehensively summarize the latest research progress on the effects of the osteokines FGF-23, IGF-1, RANKL and osteocalcin on muscle to explore whether these cytokines can be utilized to treat and prevent sarcopenia.

RESULTS OF INTRALESIONAL TRIAMCINOLONE ACETONIDE FOR CHALAZION TREATMENT

2011 ◽  
pp. 100-104
Author(s):  
Thi Thu Nguyen ◽  
Viet Hien Vo ◽  
Thi Em Do
Keyword(s):  
Success Rate ◽  
Key Words ◽  
Triamcinolone Acetonide ◽  
Lower Eyelid ◽  
Upper Eyelid ◽  
Interventional Trial ◽  
The Mean ◽  
First Time

The study use intralesional triamcinolone acetonide injection proceduce for chalazion treatment.1. Objectives: To evaluate results of intralesional triamcinolone acetonide injection for chalazion treatment. 2. Method: This noncomparative prospective interventional trial included 72 chalazions of 61 patients. 3. Results: 61 patients (72 chalazions) with 19 males (31.1%) và 42 females (68.9%), the mean age was 24 ± 9,78 years. 31.1% patients was the first time chalazion and 68.9% patients was more than one times chalazion including 78.6% patients was recurrent at the first position and 21.4% patients occur at new position. 72 chalazions with 16 (22.2%) chalazions was treated before and 56 (77.8%) chalazions wasn’t done that. 72 chalazions with 49 chalazions (68.1%) are local in upper eyelid and 23 chalazions (31.9%) are local in lower eyelid. The mean of chalazion diameter is 6.99 ± 3.03mm. Intralesional triamcinolone acetonide is injected to treat 72 chalazions with 16 (22.2%) chalazions are injected through the route of skin and 56 (77.8%) chalazions are injected through the route of conjunctiva. After 2 weeks follow-up, the success rate was 93.1% and 6.9% failed. 4. Conclusion: intralesional triamcinolone acetonide injection for chalazion treatment is really effective. Key words: chalazion, intralesional triamcinolone acetonide.

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