The interfacial length scale which affect the simulation accuracy of boiling heat transfer was derived by theorety principle. The boiling heat transfer in vertical rectangular channel was simulated by CFX based on Euler-Euler model. The simulation was validated by the experiment data in literature. The result show that the error between simulation and experiment is within ± 15%. These results would provide some constructive instructions in interfacial length scale which is determined in CFX and the investigation of boiling heat transfer mechanism in vertical rectangular channel.