After an analysis of gaps in implementing digital accessibility policies in the region, this chapter reviews five country case studies (Brazil, Colombia, Costa Rica, Ecuador, and Guyana) of successful innovations leveraging their fast-expanding mobile and internet services ecosystems that could be easily replicated across the region. Those findings support the thesis that, with better policies and capacity to implement, Latin American and Caribbean countries are in a favorable position to leapfrog in promoting digital accessibility and assistive technologies and services for persons with disabilities by capitalizing on their mobile and internet infrastructure and common languages.