A STUDY TO COMPARE FUNDUS FLUORESCEIN ANGIOGRAPHY AND OPTICAL COHERENCE TOMOGRAPHY IN AGE RELATED MACULAR DEGENERATION

Abstract Age-related macular degeneration is a leading cause of irreversible vision loss in individuals over 55 years of age worldwide. Conventionally, it is divided into two subtypes – dry (non-neovascular) and wet (neovascular) form. Neovascular age-related macular degeneration comprises only 10-15% of all patients but is responsible for more than 80% of blindness related to the disease. It requires early diagnosis and timely treatment. Fluorescein angiography is the current ‘gold standard’ for diagnosing neovascular forms. However, as an invasive procedure, it may be contraindicated in some circumstances and cause serious adverse effects. Optical coherence tomography-angiography is a relatively new, non-invasive and fast imaging modality gaining popularity in the diagnosis of age-related macular degeneration, especially for the neovascular form of the disease. It enables structural and functional information of blood vessels in the retina and choroid, without the need of an intravenous dye. In this study we present and discuss 3 cases of different subtypes of choroidal neovascularization secondary to neovascular age-related macular degeneration. All of them were examined by fluorescein angiography and optical coherence tomography-angiography. The results were qualitatively analyzed.

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Correlation of optical coherence tomography and fluorescein angiography imaging in neovascular age-related macular degeneration

Menoufia Medical Journal ◽

10.4103/1110-2098.173611 ◽

2015 ◽

Vol 28 (4) ◽

pp. 902

Author(s):

AsmaaZ Fadel ◽

Abd El-KhalekI El-Sadany ◽

HatemM Marey ◽

MoatazF El-Sawy

Keyword(s):

Optical Coherence Tomography ◽

Macular Degeneration ◽

Fluorescein Angiography ◽

Age Related Macular Degeneration ◽

Optical Coherence ◽

Age Related

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Grading of Age-Related Macular Degeneration: Comparison between Color Fundus Photography, Fluorescein Angiography, and Spectral Domain Optical Coherence Tomography

Journal of Ophthalmology ◽

10.1155/2013/385915 ◽

2013 ◽

Vol 2013 ◽

pp. 1-6 ◽

Cited By ~ 27

Author(s):

Nils F. Mokwa ◽

Tina Ristau ◽

Pearse A. Keane ◽

Bernd Kirchhof ◽

Srinivas R. Sadda ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Macular Degeneration ◽

Fluorescein Angiography ◽

Age Related Macular Degeneration ◽

Spectral Domain ◽

Fundus Photography ◽

Optical Coherence ◽

Age Related ◽

Sensitivity Specificity ◽

And Control

Purpose. To compare color fundus photography (FP), fluorescein angiography (FA), and spectral domain optical coherence tomography (SDOCT) for the detection of age-related macular degeneration (AMD), choroidal neovascularisation (CNV), and CNV activity.Methods. FPs, FAs, and SDOCT volume scans from 120 eyes of 66 AMD and control patients were randomly collected. Control eyes were required to show no AMD, but other retinal pathology was allowed. The presence of drusen, pigmentary changes, CNV, and signs for CNV activity was independently analyzed for all imaging modalities.Results. AMD was diagnosed based on FP in 75 eyes. SDOCT and FA showed sensitivity (specificity) of 89% (76%) and 92% (82%), respectively. CNV was present on FA in 68 eyes. Sensitivity (specificity) was 78% (100%) for FP and 94% (98%) for SDOCT. CNV activity was detected by SDOCT or FA in 60 eyes with an agreement in 46 eyes. Sensitivity was 88% for SDOCT and 88% for FA. FP showed sensitivity of 38% and specificity of 98%.Conclusions. CNV lesions and activity may be missed by FP alone, but FP may help identifying drusen and pigmentary changes. SDOCT is highly sensitive for the detection of AMD, CNV, and CNV activity; however, it cannot fully replace FA.

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