Malignant Mixed Germ Cell Ovarian Tumor in Pregnant Female

Ovarian germ cell tumours comprise approximately 15% to 20% of all ovarian neoplasms. In pregnant females, its incidence is very low. They arise from primordial germ cells derived from the embryonal gonad. Malignant germ cell tumours comprise less than 5% of all ovarian neoplasms. Most malignant ovarian neoplasms in pregnant women are at early stages and are associated with good prognosis both for the mother and for the neonate. Histologic subtypes and prognosis do not differ from tumors not associated with pregnancy. Careful initial surgery with adequate staging biopsies followed by combination chemotherapy can greatly improve the prognosis of these patients. We present a case of malignant mixed germ cell tumor in a pregnant female who presented with abdominal mass after delivering a normal child. Histological and biochemical tumour markers confirmed it to be malignant mixed germ cell tumor.

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A rare case of mixed germ cell tumor in a teenage girl: a case report

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20172378 ◽

2017 ◽

Vol 6 (6) ◽

pp. 2663

Author(s):

Faraz S. Vali ◽

Amit Kyal ◽

Parul I. Chaudhary ◽

Sujatha Das ◽

Aprateem Mukherjee ◽

...

Keyword(s):

Germ Cell ◽

Germ Cell Tumor ◽

Embryonal Carcinoma ◽

Germ Cell Tumors ◽

Cell Tumor ◽

Ca 125 ◽

Gestational Choriocarcinoma ◽

Mixed Germ Cell Tumor ◽

Initial Surgery ◽

Alpha Feto Protein

Germ cell tumors represent only 20% to 25% of all benign and malignant ovarian neoplasms. Mixed germ cell tumors are a rare variety of non–dysgerminomatous germ cell tumors. They contain two or more elements; the most frequent combination being a dysgerminoma and an EST (Endodermal Sinus Tumor). We present a case of malignant mixed germ cell tumor comprising of yolk sac tumor, embryonal carcinoma and choriocarcinoma. A 13-year-old girl presented with a huge 25 x 18 cm mass in abdomen with raised values of CA-125, hCG, AFP (alpha-feto protein) and LDH (lactate dehydrogenase). She underwent laparotomy followed by unilateral salpingoopherectomy and infracolic omentectomy. Histopathology report revealed malignant mixed germ cell tumor comprising predominantly of EST with elements of embryonal carcinoma and non-gestational choriocarcinoma. Following surgery, she was started on adjuvant chemotherapy (Bleomycin, Etoposide and Cisplatin regimen). Mixed germ cell tumor (YST/EST, non-gestational choriocarcinoma and embryonal carcinoma) is a very rare tumor. Careful initial surgery with adequate staging biopsies followed by combination chemotherapy can greatly improve the prognosis of these patients

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OVARIAN GONADOBLASTOMA WITH MIXED GERM CELL TUMOR IN A 16-YEAR-OLD GIRL WITH 46, XX KARYOTYPE: A CASE REPORT

10.26226/morressier.5770e29cd462b80290b4bd28 ◽

2016 ◽

Author(s):

Zeliha Firat Cuylan

Keyword(s):

Case Report ◽

Germ Cell ◽

Germ Cell Tumor ◽

Cell Tumor ◽

Mixed Germ Cell Tumor

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The case of prenatal diagnosis of a germ cell tumor of the fetal ovary

10.21516/2413-1458-2018017-2-160-163 ◽

2018 ◽

Author(s):

N.N. Bondarenko, E.Yu. Andreeva , N.B. Filippova

Keyword(s):

Germ Cell ◽

Germ Cell Tumor ◽

Ovarian Tumor ◽

Ultrasound Examination ◽

Abdominal Mass ◽

Abdominal Cavity ◽

Cell Tumor ◽

Fetal Ovary ◽

Entire Abdominal Cavity ◽

Spontaneous Delivery

A case of prenatal ultrasound diagnosis of a rare congenital ovarian tumor is presented. By ultrasound examination at 36–37 weeks of gestation the intra-abdominal mass 66  47  74 mm occupying the entire abdominal cavity was discovered. At 38 weeks of pregnancy spontaneous delivery occurred with girl weight 2840 g. On the eighth day after birth the child has been successfully undergone surgery. Histological examination revealed congenital germ-cell tumor with structures of dysgerminoma and yolk sac tumor.

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442 Familial swyer syndrome associated with mixed germ cell tumor: a case report

10.1136/ijgc-2020-igcs.383 ◽

2020 ◽

Author(s):

M David ◽

C Castro

Keyword(s):

Case Report ◽

Germ Cell ◽

Germ Cell Tumor ◽

Cell Tumor ◽

Mixed Germ Cell Tumor ◽

Swyer Syndrome

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Mediastinal mixed germ cell tumor: A case report and literature review

Open Medicine ◽

10.1515/med-2021-0293 ◽

2021 ◽

Vol 16 (1) ◽

pp. 892-898

Author(s):

Xianwen Hu ◽

Dandan Li ◽

Jinhua Xia ◽

Pan Wang ◽

Jiong Cai

Keyword(s):

Germ Cell ◽

Germ Cell Tumor ◽

Embryonal Carcinoma ◽

Yolk Sac ◽

Immature Teratoma ◽

Cell Tumor ◽

Yolk Sac Tumor ◽

Medical Attention ◽

Ct Guided ◽

Mixed Germ Cell Tumor

Abstract Mixed germ cell tumor (MGCT) mainly occurs in young women’s ovaries and men’s testicles and rarely occurs outside the gonad. Fewer than 10 cases of mediastinal MGCT are available in PubMed, Embase, and other databases in English, while mediastinal MGCT with three pathological components, such as yolk sac tumor, immature teratoma, and embryonal carcinoma, has not been reported previously. A 12-year-old male sought medical attention for chest discomfort and underwent a computed tomography (CT) scan. A large soft tissue mass occupying most of the left thoracic cavity and mediastinum was detected. A CT-guided biopsy was performed, and an MGCT was diagnosed with pathological components, including yolk sac tumor, immature teratoma, and a small amount of embryonal carcinoma. Due to the large size of the tumor, the patient was treated with an EP regimen (etoposide + cisplatin) and paclitaxel + ifosfamide + cisplatin interstitial chemotherapy. The patient was followed up for 6 months and was alive with the disease. To the best of our knowledge, this is the 10th patient with MGCT in the mediastinum. The incidence of mediastinal MGCT is low, but it should still be considered one of the differential diagnoses of isolated pleural fibroma and neurogenic tumors.

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