The case of prenatal diagnosis of a germ cell tumor of the fetal ovary

2018 ◽  
Author(s):  
N.N. Bondarenko, E.Yu. Andreeva , N.B. Filippova
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Ovarian Tumor ◽  
Ultrasound Examination ◽  
Abdominal Mass ◽  
Abdominal Cavity ◽  
Cell Tumor ◽  
Fetal Ovary ◽  
Entire Abdominal Cavity ◽  
Spontaneous Delivery

A case of prenatal ultrasound diagnosis of a rare congenital ovarian tumor is presented. By ultrasound examination at 36–37 weeks of gestation the intra-abdominal mass 66  47  74 mm occupying the entire abdominal cavity was discovered. At 38 weeks of pregnancy spontaneous delivery occurred with girl weight 2840 g. On the eighth day after birth the child has been successfully undergone surgery. Histological examination revealed congenital germ-cell tumor with structures of dysgerminoma and yolk sac tumor.

scholarly journals Multi-region exome sequencing of ovarian teratomas reveals 2N near-diploid genomes, paucity of somatic mutations, and extensive allelic imbalances shared across mature, immature, and disseminated components

2019 ◽  
Author(s):  
Michael B. Heskett ◽  
John Z. Sanborn ◽  
Christopher Boniface ◽  
Benjamin Goode ◽  
Jocelyn Chapman ◽  
...  
Keyword(s):  
Germ Cell ◽  
Exome Sequencing ◽  
Loss Of Heterozygosity ◽  
Germ Cell Tumor ◽  
Ovarian Tumor ◽  
Somatic Mutations ◽  
Immature Teratoma ◽  
Cell Tumor ◽  
Malignant Germ Cell Tumor ◽  
The Right

AbstractImmature teratoma is a subtype of malignant germ cell tumor of the ovary that occurs most commonly in the first three decades of life, frequently with bilateral ovarian disease. Despite being the second most common malignant germ cell tumor of the ovary, little is known about its genetic underpinnings. Here we performed multi-region whole exome sequencing to interrogate the genetic zygosity, clonal relationship, DNA copy number, and mutational status of 52 pathologically distinct tumor components from 10 females with ovarian immature teratomas, with bilateral tumors present in 5 cases and peritoneal dissemination in 7 cases. We found that ovarian immature teratomas are genetically characterized by 2N near-diploid genomes with extensive loss of heterozygosity and an absence of genes harboring recurrent somatic mutations or known oncogenic variants. All components within a single ovarian tumor (immature teratoma, mature teratoma with different histologic patterns of differentiation, and yolk sac tumor) were found to harbor an identical pattern of loss of heterozygosity across the genome, indicating a shared clonal origin. In contrast, the 4 analyzed bilateral teratomas showed distinct patterns of zygosity changes in the right versus left sided tumors, indicating independent clonal origins. All disseminated teratoma components within the peritoneum (including gliomatosis peritonei) shared a clonal pattern of loss of heterozygosity with either the right or left primary ovarian tumor. The observed genomic loss of heterozygosity patterns indicate that diverse meiotic errors contribute to the formation of ovarian immature teratomas, with 11 out of the 15 genetically distinct clones determined to result from the failure of meiosis I or II. Overall, these findings suggest that copy-neutral loss of heterozygosity resulting from meiotic abnormalities may be sufficient to generate ovarian immature teratomas from germ cells.

scholarly journals Malignant Mixed Germ Cell Ovarian Tumor in Pregnant Female

2013 ◽  
Vol 2 (2) ◽  
pp. 233
Author(s):  
S. Kaur ◽  
V. K. Bodal ◽  
M. S. Bal ◽  
R. Bhagat ◽  
N. Gupta
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Ovarian Neoplasms ◽  
Abdominal Mass ◽  
Primordial Germ Cells ◽  
Cell Tumor ◽  
Pregnant Female ◽  
Germ Cell Tumours ◽  
Mixed Germ Cell Tumor ◽  
Initial Surgery

Ovarian germ cell tumours comprise approximately 15% to 20% of all ovarian neoplasms. In pregnant females, its incidence is very low. They arise from primordial germ cells derived from the embryonal gonad. Malignant germ cell tumours comprise less than 5% of all ovarian neoplasms. Most malignant ovarian neoplasms in pregnant women are at early stages and are associated with good prognosis both for the mother and for the neonate. Histologic subtypes and prognosis do not differ from tumors not associated with pregnancy. Careful initial surgery with adequate staging biopsies followed by combination chemotherapy can greatly improve the prognosis of these patients. We present a case of malignant mixed germ cell tumor in a pregnant female who presented with abdominal mass after delivering a normal child. Histological and biochemical tumour markers confirmed it to be malignant mixed germ cell tumor.

scholarly journals Rapidly enlarging abdominal mass in a patient with recurrent germ cell tumor

2019 ◽  
Vol 7 (11) ◽  
pp. 2285-2286
Author(s):  
Lauren Ho ◽  
Louis Pisters ◽  
Shi‐Ming Tu
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Abdominal Mass ◽  
Cell Tumor

scholarly journals A Case Report on Malignant Ovarian Germ Cell Tumor

2021 ◽  
pp. 43-47
Author(s):  
Sanket V. Madavi ◽  
Samruddhi Gujar ◽  
Ranjana Sharma ◽  
Ruchira Ankar ◽  
Savita Pohekar ◽  
...  
Keyword(s):  
Weight Loss ◽  
Case Report ◽  
Germ Cell ◽  
Germ Cell Tumor ◽  
Therapeutic Intervention ◽  
Abdominal Mass ◽  
Germ Cell Tumors ◽  
Clinical Findings ◽  
Cell Tumor ◽  
Intervention Patient

Introduction: A germ cell is a type of Tumor that arises from germ cell (GCT). Germ cell tumors are both cancerous and benign. The gonads contains majority of germ cell (ovary and testis). GCT that arise outside the gonads could be the result of embryo devlopment errors. Clinical Findings: Abdominal mass without pain, backache, and weight loss. Diagnostic Evaluation: HCG and alphafetoprotein level in the blood identifying women with malignant ovarian germ cell tumor is beneficial. Serum alphafetoprotein and HCG is elevated as condition progress. Therapeutic Intervention: Patient treated with inj. Bleomycin, inj. Cisplatin, inj.Etoposide, tab Pan 40 miligram and inj. Emset. Conclusion: A 3year old female was admitted in AVBRH Sawangi Meghe wardha with the major complaint of right abdominal swelling for 6 month, both when they observed abdominal mass without pain and swelling was small in size and backache and weight loss.

scholarly journals Clinical Characteristics of Pediatric with Germ Cell Tumor: Experience in a Developing Country

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Lelani Reniarti ◽  
Anisah Febri ◽  
Nur Melani Sari
Keyword(s):  
Nutritional Status ◽  
Germ Cell ◽  
Germ Cell Tumor ◽  
Clinical Characteristics ◽  
Abdominal Mass ◽  
Clinical Manifestations ◽  
Cell Tumor ◽  
Cross Sectional ◽  
Common Location ◽  
End Of Treatment

Background: Germ cell tumor (GCT) occurs in 3% of pregnancy malignancies and increases by 15% during adolescence. In developing countries, the five-year survival rate is 98% and 80% for GCT earlier stage and malignant tumor, respectively. This study aimed to gather information about clinical manifestations of GCT and to evaluate the treatment outcome in pediatric GCT patients at Dr. Hasan Sadikin General Hospital, Bandung, IndonesiaMethods: A descriptive cross-sectional study design with a total sampling method was conducted using secondary data from the medical record of pediatric patients diagnosed with GCT from 2015 to 2018. Data on nutritional status, clinical characteristics, histopathology stage, hematological profiles, chemical markers, treatment methods, completeness of treatment, and outcome at the end of treatment were collected and presented using tables and charts.Results: Of the 44 subjects, girls (77.3%) were predominant, with a mean age of 2 years old and normal nutritional status (59.1%). Patients generally had abdominal mass (97.7%) and most had intragonadal GCT (95.5%), with ovarium (76.2%) as the most common location. The most frequent GCT histopathology was yolk sac tumor (34.1%), with an Alpha-fetoprotein (AFP) level of >100.000 (6.8%). Almost all patients (97.7%) had undergone surgery; however, 47% of patients did not complete their treatment. At the end of treatment, the majority of patients survived (86.4%).Conclusion: Germ cell tumor has various clinical characteristics. Understanding these characteristics will enable clinicians to make a proper diagnosis and provide immediate management that will lead to a better prognosis.

scholarly journals Clinicopathological study of benign ovarian tumuors

2018 ◽  
Vol 6 (8) ◽  
pp. 2750
Author(s):  
Nikita V. Vohra ◽  
Cyrus Dara Jokhi ◽  
Sujata R. Kanetkar
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Ovarian Tumor ◽  
Malignant Tumors ◽  
Ovarian Neoplasm ◽  
Cell Tumor ◽  
Ovarian Tumors ◽  
Age Group ◽  
Common Procedure ◽  
Epithelial Tumour

Background: The incidence of ovarian tumor amongst gynecological admissions have been reported to vary from 1-3 %. About 75% of these tumors have been found to be benign. Ovarian malignancies represent the greatest clinical challenge of all the gynecological malignancies. During the reproductive years most of the ovarian tumors encountered are benign. About 2/3 of the ovarian tumors are encountered in this group only. The chance that an ovarian tumor is malignant in a patient younger than 45 years is 1 in 15. The differentiation of the benign from malignant tumors can go wrong even with imaging modalities.CA125 along with ultrasound are useful in differentiating benign from malignant tumors. Histopathological examination is gold standard for diagnosis of ovarian neoplasm.Methods: The present study includes consecutive cases of histopathologically proven ovarian tumors of 3 years from June 2010 to May 2013 reported by the Department of Pathology of our tertiary care center. It includes total 150 cases. After careful study of gross findings, appropriate bits were taken from received ovarian specimen, followed by routine paraffin processing to make H and E stained slides. Special stains were used wherever needed.Results: Majority of the cases 91 (60.67%) were benign, 53 (35.33%) were malignant and 6 (4.0%) were borderline. Surface epithelial tumours were the most common type (68.13%) of ovarian neoplasm in this study. Most of tumours in our study occurred in the age group of 21-40 years. Mucinous cystadenomas were most common benign surface epithelial tumour and most common benign tumors overall. There were 22 cases of benign germ cell tumor, all were mature teratoma. All the sex-cord stromal tumours were diagnosed in women older than 40 years. Most common benign lesion in our study is surface epithelial tumour and in age group of 21-40 years. 84% patients studied had symptoms at presentation, out of which 26% of patient presented with dull/dragging pain. Pan hysterectomy was the most common procedure for surgical management.Conclusions: Most of ovarian neoplasm are benign with mucinous cystadenoma being commonest entity. Commonest age group is 21-40 years. Commonest benign germ cell tumor is Mature cystic teratoma. Commonest clinical symptom is dull/dragging pain. Pan hysterectomy was the most common procedure for surgical management. 

scholarly journals Case Report: A Rare Case of a Combination of Omphalocele With Umbilical Teratoma

2021 ◽  
Vol 9 ◽  
Author(s):  
Ruslan Bilal ◽  
Dastan Rustemov ◽  
Zhenis Sakuov ◽  
Bahytkaly Ibraimov ◽  
Arman Kozhakhmetov
Keyword(s):  
Case Report ◽  
Germ Cell ◽  
Germ Cell Tumor ◽  
Rare Case ◽  
Mature Teratoma ◽  
Abdominal Cavity ◽  
Single Step ◽  
Cell Tumor ◽  
Simultaneous Operation ◽  
Different Types

Omphalocele is a congenital malformation of the abdominal wall, which occurs with a frequency of 1–5,000 newborns. The prognosis of treatment often depends on the presence of concomitant malformations. The most common contents of the hernia with omphalocele are the intestinal loops, liver, spleen. However, all organs of the abdominal cavity can be part of the hernial sac with large sizes of omphalocele. Teratoma is a germ cell tumor made up of several different types of tissue, such as hair, muscle, teeth, or bone. They are a type of germ cell tumor and divided into two types: mature and immature. In this article, we describe a rare case of a combination of an omphalocele with a mature teratoma and report the successful single step surgical treatment. On the first day after birth, a simultaneous operation—Removal of teratoma with abdominoplasty was performed. The postoperative period was uneventful, and the child was discharged for recovery.

scholarly journals Unresolved abdominal mass

1970 ◽  
Vol 7 (1) ◽  
pp. 82-85 ◽  
Author(s):  
B Shrestha ◽  
JL Baidya
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Abdominal Mass ◽  
Human Chorionic Gonadotrophin ◽  
Cell Tumor ◽  
Complete Disappearance ◽  
Solid Mass ◽  
Undescended Testes ◽  
Provisional Diagnosis ◽  
To Come

A case of huge enhancing solid mass in the abdomen observed in 30 years old gentlemen is reported. Patient was worked up and managed conservatively outside valley with the provisional diagnosis of an appendicular lump. When examined, he was found to have huge intra abdominal mass. Interestingly when the genitalia was examined he was found to have underdeveloped empty scrotum without testes in it which he was yet not bothered. This simple examination gave us a straight clue to come up with the diagnosis of malignancy in undescended testes. Laparotomy was performed and the mass was excised. After 6 weeks postoperatively he was subjected for the chemotherapy. After 3 cycles of chemotherapy CT scan showed complete disappearance of retroperitoneal lymphadenopathy and serum tumor markers have come down to normal level. Key words: Germ cell tumor (GCT), Seminoma, Non seminomatous germ cell tumor, (NSGCT), Cryptorchidism, Alpha fetoprotein (AFP), Beta human chorionic gonadotrophin (BHCG), Lactate dehydrogenase (LDH) doi: 10.3126/kumj.v7i1.1773 Kathmandu University Medical Journal (2009), Vol. 7, No. 1, Issue 25, 82-85

scholarly journals Double Pathology: Malignant Epithelial Ovarian Tumor and Germ Cell Tumor (Choriocarcinoma), a Rare Coexistence

2015 ◽  
Vol 6 (4) ◽  
pp. 421-425 ◽  
Author(s):  
Gouthaman Shanmugasundaram ◽  
Elilnambi Sundaramoorthy ◽  
Suresh Sudalaiandi ◽  
Satish Srinivas Kondaveeti ◽  
Thanka Johnson ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Ovarian Tumor ◽  
Cell Tumor ◽  
Epithelial Ovarian Tumor
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