scholarly journals Towards a Mathematical Framework for Method Validation and Performance Characteristics of Non-targeted Methods for Food Authenticity

2021 ◽  
Author(s):  
Kapil Nichani ◽  
Steffen Uhlig ◽  
Manfred Stoyke ◽  
Sabine Kemmlein ◽  
Franz Ulberth ◽  
...  
Keyword(s):  
Academic Research ◽  
Performance Characteristics ◽  
Mathematical Framework ◽  
Food Authenticity ◽  
Commercial Development ◽  
Official Control ◽  
Food And Feed ◽  
Fit For Purpose ◽  
New Form ◽  
And Performance

Through its suggestive name, non-targeted methods (NTMs) do not aim at a predefined "needle in the haystack". Instead, they exploit all the constituents of the haystack. This new form of analytical methods is increasingly finding applications in food and feed testing. However, the concepts, terms, and considerations related to this burgeoning field of analytical testing needs to be propagated for the benefit of ones associated in academic research, commercial development, and official control. This paper addresses the frequently asked questions around notations and terminologies surrounding NTMs. The widespread development and adoption of these methods also necessitates the need to develop approaches to NTM validation, i.e., evaluating the performance characteristics of a method to determine if it is fit-for-purpose. This work aims to provide a roadmap to approaching NTM validation. In doing so, the paper deliberates on the different considerations that influence the approach to validation and provides suggestions thereof.

scholarly journals Essential Terminology and Considerations for Validation of Non-targeted Methods

2021 ◽  
Author(s):  
Kapil Nichani ◽  
Steffen Uhlig ◽  
Manfred Stoyke ◽  
Sabine Kemmlein ◽  
Franz Ulberth ◽  
...  
Keyword(s):  
Analytical Methods ◽  
Academic Research ◽  
Performance Characteristics ◽  
Commercial Development ◽  
Official Control ◽  
Food And Feed ◽  
Fit For Purpose ◽  
New Form

Through its suggestive name, non-targeted methods (NTMs) do not aim at a predefined "needle in the haystack". Instead, they exploit all the constituents of the haystack. This new form of analytical methods is increasingly finding applications in food and feed testing. However, the concepts, terms, and considerations related to this burgeoning field of analytical testing needs to be propagated for the benefit of ones associated in academic research, commercial development, and official control. This paper addresses the frequently asked questions around notations and terminologies surrounding NTMs. The widespread development and adoption of these methods also necessitates the need to develop approaches to NTM validation, i.e., evaluating the performance characteristics of a method to determine if it is fit-for-purpose. This work aims to provide a roadmap to approaching NTM validation. In doing so, the paper deliberates on the different considerations that influence the approach to validation and provides suggestions thereof.

Acoustic and Performance Characteristics of an Ideally Twisted Rotor in Hover

2021 ◽  
Author(s):  
Nicole A. Pettingill ◽  
Nikolas S. Zawodny ◽  
Christopher Thurman ◽  
Leonard V. Lopes
Keyword(s):  
Performance Characteristics ◽  
And Performance

scholarly journals First-of-a-kind muography for nuclear waste characterization

2018 ◽  
Vol 377 (2137) ◽  
pp. 20180048 ◽  
Author(s):  
David Mahon ◽  
Anthony Clarkson ◽  
Simon Gardner ◽  
David Ireland ◽  
Ramsey Jebali ◽  
...  
Keyword(s):  
Nuclear Waste ◽  
Imaging System ◽  
Academic Research ◽  
Cosmic Ray ◽  
Laboratory Facility ◽  
Waste Container ◽  
High Resolution Images ◽  
And Performance ◽  
The Uk ◽  
The University

In the last decade, there has been a surge in the number of academic research groups and commercial companies exploiting naturally occurring cosmic-ray muons for imaging purposes in a range of industrial and geological applications. Since 2009, researchers at the University of Glasgow and the UK National Nuclear Laboratory (NNL) have pioneered this technique for the characterization of shielded nuclear waste containers with significant investment from the UK Nuclear Decommissioning Authority and Sellafield Ltd. Lynkeos Technology Ltd. was formed in 2016 to commercialize the Muon Imaging System (MIS) technology that resulted from this industry-funded academic research. The design, construction and performance of the Lynkeos MIS is presented along with first experimental and commercial results. The high-resolution images include the identification of small fragments of uranium within a surrogate 500-litre intermediate level waste container and metal inclusions within thermally treated GeoMelt® R&D Product Samples. The latter of these are from Lynkeos' first commercial contract with the UK National Nuclear Laboratory. The Lynkeos MIS will be deployed at the NNL Central Laboratory facility on the Sellafield site in Summer 2018 where it will embark upon a series of industry trials. This article is part of the Theo Murphy meeting issue ‘Cosmic-ray muography’.

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