Choroidal Alterations of Sturge-weber Syndrome Secondary Glaucoma and Non-glaucoma Port-wine Stain Patients Distinguished by Enhanced Depth Imaging Optical Coherence Tomography

Abstract Background: To evaluate the choroidal changes in Sturge-Weber syndrome (SWS) secondary glaucoma and non-glaucoma port-wine stain (PWS) patients by enhanced depth imaging optical coherence tomography (EDI-OCT).Methods: SWS and PWS patients who were over 3 years old and treated or screened at our ophthalmology department were included in the study. Baseline demographics, EDI-OCT and fundus photography data were collected from all patients.Results: Forty-six non-glaucoma PWS (NGPWS) patients and 35 SWS secondary glaucoma（SG）patients were included, with mean ages of 16.52±13.63 and 13.94±8.27 years, respectively (p>0.05). Among these patients, 2 exhibit bilateral PWS and unilateral glaucoma. Thus the two eyes of each person were divided into NGPWS group and SG group respectively. Twenty-one eyes had choroidal hemangiomas and 7 eyes had excessive thickening of the choroid without choroidal hemangiomas. Choroidal hemangiomas were only observed in ipsilateral eyes of SG patients. The choroidal thicknesses of the ipsilateral and contralateral eyes of NGPWS patients were 358.10±117.40 μm (45 eyes) and 288.20±79.04 μm (41 eyes), respectively (p<0.05). The choroidal thicknesses of the ipsilateral and contralateral eyes of SG patients were 511.40±242.10 μm (15 eyes) and 283.90±92.27 μm (29 eyes), respectively (p<0.05). Significant differences were found between the ipsilateral eyes of SWS and PWS patients (p<0.05). Six of 12 eyes (50%) with choroidal hemangiomas exhibited post-operative posterior segment complications. Conclusions: Non-glaucoma PWS and SWS secondary glaucoma patients had a thicker choroid in the ipsilateral eye. The trend was even more pronounced in SWS secondary glaucoma patients. Choroidal hemangiomas were only found in the ipsilateral eyes of SG. In addition, choroidal hemangioma was a risk factor for post-operative posterior segment complications in SWS patients.

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Choroidal Alterations of Sturge-Weber Syndrome Secondary Glaucoma and Non-glaucoma Port-wine Stain Patients Distinguished by Enhanced Depth Imaging Optical Coherence Tomography

10.21203/rs.3.rs-41801/v2 ◽

2020 ◽

Author(s):

Yue Wu ◽

Lulu Huang ◽

Yixin Liu ◽

Li Xu ◽

Wenyi Guo

Keyword(s):

Optical Coherence Tomography ◽

Secondary Glaucoma ◽

Posterior Segment ◽

Enhanced Depth Imaging ◽

Port Wine Stain ◽

Port Wine ◽

Depth Imaging ◽

Weber Syndrome ◽

Sturge Weber Syndrome ◽

Imaging Optical Coherence Tomography

Abstract Background: To evaluate the choroidal changes in Sturge-Weber syndrome (SWS) secondary glaucoma and non-glaucoma port-wine stain (PWS) patients by enhanced depth imaging optical coherence tomography (EDI-OCT).Methods: SWS and PWS patients who were over 3 years old and treated or screened at our ophthalmology department were included in the study. Baseline demographics, EDI-OCT and fundus photography data were collected from all patients.Results: Forty-six non-glaucoma PWS (NGPWS) patients and 35 SWS secondary glaucoma（SG）patients were included, with mean ages of 16.52±13.63 and 13.94±8.27 years, respectively (p>0.05). Among these patients, 2 exhibit bilateral PWS and unilateral glaucoma. Thus the two eyes of each person were divided into NGPWS group and SG group respectively. Twenty-one eyes had choroidal hemangiomas and 7 eyes had excessive thickening of the choroid without choroidal hemangiomas. Choroidal hemangiomas were only observed in ipsilateral eyes of SG patients. The choroidal thicknesses of the ipsilateral and contralateral eyes of NGPWS patients were 358.10±117.40 μm (45 eyes) and 288.20±79.04 μm (41 eyes), respectively (p<0.05). The choroidal thicknesses of the ipsilateral and contralateral eyes of SG patients were 511.40±242.10 μm (15 eyes) and 283.90±92.27 μm (29 eyes), respectively (p<0.05). Significant differences were found between the ipsilateral eyes of SWS and PWS patients (p<0.05). Six of 13 eyes (46%) with choroidal hemangiomas exhibited post-operative posterior segment complications. Conclusions: Non-glaucoma PWS and SWS secondary glaucoma patients had a thicker choroid in the ipsilateral eye. The trend was even more pronounced in SWS secondary glaucoma patients. Choroidal hemangiomas were only found in the ipsilateral eyes of SG. In addition, choroidal hemangioma was a risk factor for post-operative posterior segment complications in SWS patients.

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Choroidal Alterations of Sturge-Weber Syndrome Secondary Glaucoma and Non-glaucoma Port-wine Stain Patients Distinguished by Enhanced Depth Imaging Optical Coherence Tomography

10.21203/rs.3.rs-41801/v3 ◽

2020 ◽

Author(s):

Yue Wu ◽

Lulu Huang ◽

Yixin Liu ◽

Li Xu ◽

Wenyi Guo

Keyword(s):

Optical Coherence Tomography ◽

Secondary Glaucoma ◽

Posterior Segment ◽

Enhanced Depth Imaging ◽

Port Wine Stain ◽

Port Wine ◽

Depth Imaging ◽

Weber Syndrome ◽

Sturge Weber Syndrome ◽

Imaging Optical Coherence Tomography

Abstract Background: To evaluate the choroidal changes in Sturge-Weber syndrome (SWS) secondary glaucoma and non-glaucoma port-wine stain (PWS) patients by enhanced depth imaging optical coherence tomography (EDI-OCT). Methods: SWS and PWS patients who were over 3 years old and treated or screened at our ophthalmology department were included in the study. Baseline demographics, EDI-OCT and fundus photography data were collected from all patients. Results: Forty-six non-glaucoma PWS (NGPWS) patients and 35 SWS secondary glaucoma(SG)patients were included, with mean ages of 16.52±13.63 and 13.94±8.27 years, respectively (p>0.05). Among these patients, 2 exhibit bilateral PWS and unilateral glaucoma. Thus the two eyes of each person were divided into NGPWS group and SG group respectively. Twenty-one eyes had choroidal hemangiomas and 7 eyes had excessive thickening of the choroid without choroidal hemangiomas. Choroidal hemangiomas were only observed in ipsilateral eyes of SG patients. The choroidal thicknesses of the ipsilateral and contralateral eyes of NGPWS patients were 358.10±117.40 μm (45 eyes) and 288.20±79.04 μm (41 eyes), respectively (p<0.05). The choroidal thicknesses of the ipsilateral and contralateral eyes of SG patients were 511.40±242.10 μm (15 eyes) and 283.90±92.27 μm (29 eyes), respectively (p<0.05). Significant differences were found between the ipsilateral eyes of SWS and PWS patients (p<0.05). Six of 13 eyes (46%) with choroidal hemangiomas exhibited post-operative posterior segment complications. Conclusions: Non-glaucoma PWS and SWS secondary glaucoma patients had a thicker choroid in the ipsilateral eye. The trend was even more pronounced in SWS secondary glaucoma patients. Choroidal hemangiomas were only found in the ipsilateral eyes of SG. In addition, choroidal hemangioma was a risk factor for post-operative posterior segment complications in SWS patients.

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Choroidal Alterations of Sturge-Weber Syndrome Secondary Glaucoma and Non-glaucoma Port-wine Stain Patients Distinguished by Enhanced Depth Imaging Optical Coherence Tomography

10.21203/rs.3.rs-41801/v4 ◽

2020 ◽

Author(s):

Yue Wu ◽

Lulu Huang ◽

Yixin Liu ◽

Li Xu ◽

Wenyi Guo

Keyword(s):

Secondary Glaucoma ◽

Posterior Segment ◽

Enhanced Depth Imaging ◽

Port Wine Stain ◽

Port Wine ◽

Depth Imaging ◽

Weber Syndrome ◽

Sturge Weber Syndrome ◽

Imaging Optical Coherence Tomography ◽

Fellow Eyes

Abstract Background: To evaluate the choroidal changes in Sturge-Weber syndrome (SWS) secondary glaucoma and non-glaucoma port-wine stain (PWS) patients by enhanced depth imaging optical coherence tomography (EDI-OCT).Methods: SWS and PWS patients who were over 3 years old and treated or screened at our ophthalmology department were included in the study. Baseline demographics, EDI-OCT and fundus photography data were collected from all patients.Results: Overall, 46 non-glaucoma PWS (NGPWS) patients and 35 SWS secondary glaucoma（SG）patients were included, with mean ages of 16.52±13.63 and 13.94±8.27 years, respectively (p>0.05). Among these patients 2 exhibited bilateral PWS and unilateral glaucoma. Thus, the two eyes of each patient were divided into NGPWS and SG group, respectively. Twenty-one eyes had choroidal hemangiomas and 7 eyes had excessive thickening of the choroid without choroidal hemangiomas. Choroidal hemangiomas were only observed in ipsilateral eyes of SG patients. The choroidal thicknesses of the ipsilateral and fellow eyes of NGPWS patients were 358.10±117.40 μm (45 eyes) and 288.20±79.04 μm (41 eyes), respectively (p<0.05). The choroidal thicknesses of the ipsilateral and fellow eyes of SG patients were 511.40±242.10 μm (15 eyes) and 283.90±92.27 μm (29 eyes), respectively (p<0.05). Significant differences were found between the ipsilateral eyes of SWS and PWS patients (p<0.05). Six of 13 eyes (46%) with choroidal hemangiomas exhibited post-operative posterior segment complications. Conclusions: NGPWS and SG patients had a thicker choroid in the ipsilateral eye. The trend was even more pronounced in SG patients. Choroidal hemangiomas were only found in the ipsilateral eyes of SG. In addition, choroidal hemangioma was a risk factor for post-operative posterior segment complications in SWS patients.

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Choroidal alterations of Sturge-Weber syndrome secondary glaucoma and non-glaucoma port-wine stain patients distinguished by enhanced depth imaging optical coherence tomography

BMC Ophthalmology ◽

10.1186/s12886-020-01744-y ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Yue Wu ◽

Lulu Huang ◽

Yixin Liu ◽

Li Xu ◽

Wenyi Guo

Keyword(s):

Secondary Glaucoma ◽

Posterior Segment ◽

Enhanced Depth Imaging ◽

Port Wine Stain ◽

Port Wine ◽

Depth Imaging ◽

Weber Syndrome ◽

Sturge Weber Syndrome ◽

Imaging Optical Coherence Tomography ◽

Fellow Eyes

Abstract Background To evaluate the choroidal changes in Sturge-Weber syndrome (SWS) secondary glaucoma and non-glaucoma port-wine stain (PWS) patients by enhanced depth imaging optical coherence tomography (EDI-OCT). Methods SWS and PWS patients who were over 3 years old and treated or screened at our ophthalmology department were included in the study. Baseline demographics, EDI-OCT and fundus photography data were collected from all patients. Results Overall, 46 non-glaucoma PWS (NGPWS) patients and 35 SWS secondary glaucoma (SG) patients were included, with mean ages of 16.52 ± 13.63 and 13.94 ± 8.27 years, respectively (p > 0.05). Among these patients 2 exhibited bilateral PWS and unilateral glaucoma. Thus, the two eyes of each patient were divided into NGPWS and SG group, respectively. Twenty-one eyes had choroidal hemangiomas and 7 eyes had excessive thickening of the choroid without choroidal hemangiomas. Choroidal hemangiomas were only observed in ipsilateral eyes of SG patients. The choroidal thicknesses of the ipsilateral and fellow eyes of NGPWS patients were 358.10 ± 117.40 μm (45 eyes) and 288.20 ± 79.04 μm (41 eyes), respectively (p < 0.05). The choroidal thicknesses of the ipsilateral and fellow eyes of SG patients were 511.40 ± 242.10 μm (15 eyes) and 283.90 ± 92.27 μm (29 eyes), respectively (p < 0.05). Significant differences were found between the ipsilateral eyes of SWS and PWS patients (p < 0.05). Six of 13 eyes (46%) with choroidal hemangiomas exhibited post-operative posterior segment complications. Conclusions NGPWS and SG patients had a thicker choroid in the ipsilateral eye. The trend was even more pronounced in SG patients. Choroidal hemangiomas were only found in the ipsilateral eyes of SG. In addition, choroidal hemangioma was a risk factor for post-operative posterior segment complications in SWS patients.

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Optical Coherence Tomography Angiography of Perilimbal Vasculature in Port-Wine Stain and Sturge-Weber Syndrome Patients

Investigative Opthalmology & Visual Science ◽

10.1167/iovs.61.4.43 ◽

2020 ◽

Vol 61 (4) ◽

pp. 43

Author(s):

ZhanLin Zhao ◽

Li Xu ◽

XuMing Ding ◽

Yue Wu ◽

Xiangyang Zhu ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Optical Coherence Tomography Angiography ◽

Optical Coherence ◽

Port Wine Stain ◽

Port Wine ◽

Weber Syndrome ◽

Sturge Weber Syndrome

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Optical Coherence Tomography Visualization of a Port-Wine Stain in a Patient With Sturge–Weber Syndrome

Dermatologic Surgery ◽

10.1097/dss.0000000000001055 ◽

2017 ◽

Vol 43 (6) ◽

pp. 889-891

Author(s):

Adam S. Aldahan ◽

Lucy L. Chen ◽

John P. Tsatalis ◽

James M. Grichnik

Keyword(s):

Optical Coherence Tomography ◽

Optical Coherence ◽

Port Wine Stain ◽

Port Wine ◽

Weber Syndrome ◽

Sturge Weber Syndrome

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Periodontal Management of Sturge-Weber Syndrome

Case Reports in Dentistry ◽

10.1155/2013/517145 ◽

2013 ◽

Vol 2013 ◽

pp. 1-4 ◽

Cited By ~ 1

Author(s):

Butchibabu Kalakonda ◽

Koppolu Pradeep ◽

Ashank Mishra ◽

Krishnanjaneya Reddy ◽

Tupili Muralikrishna ◽

...

Keyword(s):

Oral Manifestations ◽

Port Wine Stain ◽

Scaling And Root Planing ◽

Port Wine ◽

Ocular Abnormalities ◽

Parietal Lobes ◽

Gingival Enlargement ◽

Weber Syndrome ◽

Sturge Weber Syndrome ◽

Neurocutaneous Syndromes

Sturge-Weber syndrome (SWS) is a sporadic disorder and is frequent among the neurocutaneous syndromes specifically with vascular predominance. This syndrome consists of constellation of clinical features like facial nevus, seizures, hemiparesis, intracranial calcifications, and mental retardation. It is characterized by focal port-wine stain, ocular abnormalities (glaucoma), and choroidal hemangioma and leptomeningeal angioma most often involving occipital and parietal lobes. The present paper reports three cases of SWS with oral manifestations and periodontal management, which included thorough scaling and root planing followed by gingivectomy with scalpel and laser in cases 1 and 3 consecutively to treat the gingival enlargement. However, the treatment in case 2 was deferred as the patient was not a candidate for periodontal surgery.

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