scholarly journals Synchronous Double Primary Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma: A Case Report and Review of the Literature

2021 ◽  
Author(s):  
Meng-Meng Qu ◽  
Yuan-Hui Zhu ◽  
Yi-Xiang Li ◽  
Zhi-fan Li ◽  
Jin-Kui Li ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Hepatic Resection ◽  
Intrahepatic Cholangiocarcinoma ◽  
Histopathological Examination ◽  
Primary Hepatocellular Carcinoma ◽  
Pathological Examination ◽  
B Virus ◽  
Poorly Differentiated

Abstract Background: Synchronous double primary hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) (sdpHCC-ICC) located separately within a single liver is extremely rare. The purpose of this study is to investigate the clinical, imaging, pathological characteristics and prognosis of patients with sdpHCC-ICC, in order to enhance our understanding of the disease and improve diagnostic and therapeutic effect.Case presentation: A 49-year-old female patient with obvious liver cirrhosis, who carried hepatitis B virus, was admitted to our hospital for physical examination. The level of α-fetoprotein (AFP) and carbohydrate antigen 19-9 (CA19-9) was found to be elevated. Abdominal ultrasonography and enhanced computed tomography revealed two solid masses located in segments (S) 4 and 6 of the liver, with malignant behaviors. The preoperation diagnosis was multiple primary hepatocellular carcinomas. We performed hepatic resection of both segments. The resected specimens revealed that the tumors in segments 4 and 6 were well-defined lesions of 5.0 cm and 2.5cm, respectively. Histopathological examination confirmed that the tumor of the 4th segment to be moderately and poorly differentiated ICC, and that the tumor of the 6th segment to be poorly differentiated HCC. Immunohistochemically, the ICC in S4 was positive for CK19 and negative for Heppar-1, while the HCC in S6 was positive for Heppar-1 and negative for CK19. Unfortunately，metastasis and recurrence of multiple organs and lymph nodes were observed only 3 months later.Conclusions: The clinical characteristics of sdpHCC-ICC are usually atypical. It is of difficulty to make an accurate preoperative diagnosis. Hepatitis B virus (HBV) and hepatitis C virus (HCV) infection were both the independent risk factor to the development of sdpHCC-ICC. In patients with chronic liver disease, careful observation with imaging examination should be necessary. Tumor markers may be valuable to the diagnosis of it. The definite diagnosis depends on pathological examination. Hepatic resection may be the preferred and most effective treatment. The prognosis of synchronous occurrence of double hepatic cancers was poorer than for either HCC or ICC, and the origin of it needs further study.

Primary hepatocellular carcinoma and hepatitis B virus infection in korea

1983 ◽  
Vol 11 (2) ◽  
pp. 99-104 ◽  
Author(s):  
Whan Kook Chung ◽  
Hee Sik Sun ◽  
Doo Ho Park ◽  
Gerald Y. Minuk ◽  
Jay H. Hoofnagle
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Primary Hepatocellular Carcinoma ◽  
Hepatitis B Virus Infection ◽  
B Virus

The Long-Term Serological Course of Asymptomatic Hepatitis B Virus Carriers and the Development of Primary Hepatocellular Carcinoma

1985 ◽  
Vol 151 (4) ◽  
pp. 604-609 ◽  
Author(s):  
W. L. M. Alward ◽  
B. J. McMahon ◽  
D. B. Hall ◽  
W. L. Heyward ◽  
D. P. Francis ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Primary Hepatocellular Carcinoma ◽  
B Virus

Hepatitis b virus antigens in human primary hepatocellular carcinoma tissues

1979 ◽  
Vol 24 (4) ◽  
pp. 421-429 ◽  
Author(s):  
A. Goudeau ◽  
Ph. Maupas ◽  
P. Coursaget ◽  
J. Drucker ◽  
J. P. Chiron ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Primary Hepatocellular Carcinoma ◽  
B Virus ◽  
Hepatitis B Virus Antigens ◽  
Virus Antigens

Aflatoxin Exposure in Singapore: Blood Aflatoxin Levels in Normal Subjects, Hepatitis B Virus Carriers and Primary Hepatocellular Carcinoma Patients

1994 ◽  
Vol 34 (4) ◽  
pp. 289-298 ◽  
Author(s):  
Tzee Cheng Chao ◽  
Dst Lo ◽  
B Chen Bloodworth ◽  
R Gunasegaram ◽  
T H Koh ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Aflatoxin B1 ◽  
Internal Standard ◽  
Normal Subjects ◽  
The Other ◽  
Primary Hepatocellular Carcinoma ◽  
Aflatoxin M1 ◽  
B Virus

Blood screening conducted on Singaporeans over 1991–1992 showed exposure to predominately aflatoxin B1 and to a lesser extent G1. The extent of exposure to B1 among three groups of residents in Singapore, namely normal subjects (n = 423), hepatitis B virus carriers (n = 302) and primary hepatocellular carcinoma (PHC) patients (n = 58) were extensive as reflected by the positive rates of 15.1, 0.7 and 1.7 per cent respectively. However, the degree of individual exposure to this toxin among the three groups was considered low as shown by the low respective mean blood levels of 5.4 ± 3.2 (range 3.0–17), 7.7 (range 7.5–7.9) and 7.5 picogrammes per ml of blood. It is not immediately clear whether or not such low levels would precipitate an undesirable health effect. The higher positive rate seen in normal subjects as compared with the other groups could be due to differences in dietary intake of aflatoxin B1, differences in metabolic patterns or both. About 70 per cent of PHC patients studied were carriers. The degree of aflatoxin B1 exposure among normal subjects in Singapore was a factor of 22.1 times less than that in Japan, 40.9 times less than that in Indonesia and 51.3 times less than that in the Philippines. Similarly, the extent of exposure among hepatitis B carriers in Singapore was a factor of 8.2 times, 39.6 times and 24.2 times less than those in the other three Asiatic countries respectively. The results reflected stringent Government control over the quality of food stuff imported into this country. As Singapore imports almost all its dietary needs from elsewhere, it can afford to be selective at a cost. Aflatoxin M1, a metabolite of B1, was most commonly encountered in the liver tissues of deceased (n = 154) who died of causes other than sickness or disease in 1992–93, consistent with our blood findings of prevalence of aflatoxin Bl. High performance liquid chromatography (HPLC) with fluorescence detection using one of the aflatoxins G2 or B2 as an internal standard was used for the detection and quantification of aflatoxins. The use of an internal standard structurally and chemically similar to those required to be quantified minimizes errors in quantifications. This is because differences in the quenching of fluorescence between specimen extracts and spiked-standard extracts were internally standardized and compensated for. The presence of an internal standard also helped to locate aflatoxins of interest more accurately. Strict decontamination procedures for cleaning glassware and apparatus were adhered to, to reduce cross-contaminations. Only duplicate-positive results were taken to be positive.

scholarly journals Risk factors for early postoperative recurrence in single and small hepatitis B virus-associated primary hepatocellular carcinoma

2020 ◽  
Vol 48 (10) ◽  
pp. 030006052096126
Author(s):  
Hongmei Jin ◽  
Hui Wang ◽  
Guanghao Li ◽  
Qingshun Hou ◽  
Wei Wu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Postoperative Recurrence ◽  
Primary Hepatocellular Carcinoma ◽  
B Virus ◽  
Drinking History ◽  
Class C ◽  
Recurrence Group

Objective To investigate the risk factors of early postoperative recurrence in patients with single and small (≤3 cm) hepatitis B virus-associated primary hepatocellular carcinoma (HBV-HCC). Methods This retrospective study analyzed patients with single and small HBV-HCC. All patients were followed up for 1 year after surgery. Results Among 182 patients, 54 patients had early recurrence within 1 year. The recurrence group had higher proportions of men, drinking history, Child–Turcotte–Pugh (CTP) class C, patients who underwent transarterial chemoembolization (TACE), and serum alpha-fetoprotein (AFP) >10 ng/mL as well as higher gamma-glutamyl transpeptidase (GGT) levels and lower total protein (TP) and CD8+ T lymphocyte levels than the no recurrence group. Cox multivariate regression analysis demonstrated that drinking history (HR, 1.312; 95% CI, 1.042–1.652), CTP class C (HR, 1.236; 95% CI, 1.037–1.473), TACE treatment (HR, 1.241; 95% CI, 1.026–1.501), GGT (HR, 1.138; 95% CI, 1.042–1.243), TP (HR, 0.729; 95% CI, 0.555–0.957), and AFP (HR, 2.519; 95% CI, 1.343–4.726) were independently associated with early postoperative recurrence. Conclusion Drinking history, CTP class C, TACE, serum AFP, GGT, and TP levels were independently associated with early postoperative recurrence in patients with single and small HBV-HCC.

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