scholarly journals Time Course of Changes in Vision-Related Quality of Life following Intravitreal Ranibizumab Treatment for Branch Retinal Vein Occlusion

2021 ◽  
Author(s):  
Shohei Morikawa ◽  
Fumiki Okamoto ◽  
Tomoya Murakami ◽  
Yoshimi Sugiura ◽  
Takahiro Hiraoka ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Retinal Vein Occlusion ◽  
Branch Retinal Vein Occlusion ◽  
Healthy Subjects ◽  
Composite Score ◽  
Intravitreal Ranibizumab ◽  
Near Vision ◽  
Vein Occlusion ◽  
Related Quality

Abstract Purpose: To assess the vision-related quality of life (VR-QOL) following intravitreal ranibizumab (IVR) for branch retinal vein occlusion (BRVO) and to evaluate subscale items of the VR-QOL.Methods: In this prospective observational multicenter study, 38 patients who underwent IVR treatment for unilateral BRVO and 28 age-matched healthy subjects were chosen. The 25-item National Eye Institute Visual Function Questionnaire (VFQ-25) and best-corrected visual acuity (BCVA) were examined before and at 3, 6, and 12 months after treatment.Results: The VFQ-25 composite score and BCVA significantly improved from 3 to 12 months after IVR treatment (P < 0.05), such that there was no significant difference between the BRVO and control groups at 12 months. All subscales of the VFQ-25, except “general health,” significantly improved after treatment, while “near vision” and “mental health” were worse than those in healthy subjects (P < 0.05). Patients with superior BRVO had a lower “near vision” score than healthy subjects after treatment (P < 0.05). BCVA in the treated eye and fellow eye had no significant relationship with the VFQ-25 composite score before and after treatment.Conclusions: The VR-QOL of patients with BRVO improved with IVR treatment and was comparable to that of healthy subjects after 12 months. Superior BRVO particularly affected near vision for a low level.

scholarly journals Relationship between stereopsis and vision-related quality of life following intravitreal ranibizumab injections for central retinal vein occlusion

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Fumiki Okamoto ◽  
Mizuki Tomioka ◽  
Tomoya Murakami ◽  
Shohei Morikawa ◽  
Yoshimi Sugiura ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Visual Acuity ◽  
Retinal Vein Occlusion ◽  
Central Retinal Vein Occlusion ◽  
Post Treatment ◽  
Intravitreal Ranibizumab ◽  
Vein Occlusion ◽  
Related Quality ◽  
Central Retinal Vein

AbstractThe study aimed to evaluate changes in stereopsis and vision-related quality of life (VR-QOL) in patients with central retinal vein occlusion (CRVO) following intravitreal ranibizumab injection (IVR) and investigate the relationship between stereopsis and VR-QOL. This study included 23 treatment-naïve patients with non-ischemic CRVO and 13 age-matched normal controls. Stereopsis, best-corrected visual acuity (BCVA), VR-QOL, and retinal microstructures were examined pre-treatment and 12 months post-treatment. The Titmus Stereo Test (TST) and TNO stereotest (TNO) were used to evaluate stereopsis. VR-QOL was evaluated using the 25-item National Eye Institute Visual Function Questionnaire (VFQ-25). IVR immediately and significantly improved the TST values, TNO values, composite VFQ-25 score, BCVA, and central foveal thickness in patients with CRVO. The 12-month post-treatment TST and TNO values were significantly worse in the CRVO group compared to those in the normal group. At the baseline, the composite VFQ-25 score significantly correlated only with the TST value. Multivariate analysis revealed significant associations between the 12-month post-treatment composite VFQ-25 score and the baseline and 12-month post-treatment TNO values. In conclusion, IVR immediately improved stereopsis in CRVO, albeit below normal levels. Stereopsis (not visual acuity) was associated with pre- and post-treatment VR-QOL in patients with CRVO.

scholarly journals Relationship Between Stereopsis and Vision-Related Quality of Life Following Intravitreal Ranibizumab Injections for Central Retinal Vein Occlusion

2021 ◽  
Author(s):  
Fumiki Okamoto ◽  
Mizuki Tomioka ◽  
Tomoya Murakami ◽  
Shohei Morikawa ◽  
Yoshimi Sugiura ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Visual Acuity ◽  
Retinal Vein Occlusion ◽  
Central Retinal Vein Occlusion ◽  
Post Treatment ◽  
Intravitreal Ranibizumab ◽  
Vein Occlusion ◽  
Related Quality ◽  
Central Retinal Vein

Abstract The study aimed to evaluate changes in stereopsis and vision-related quality of life (VR-QOL) in patients with central retinal vein occlusion (CRVO) following intravitreal ranibizumab injection (IVR) and investigate the relationship between stereopsis and VR-QOL. This study included 23 treatment-naïve patients with CRVO and 13 age-matched normal controls. Stereopsis, best-corrected visual acuity (BCVA), VR-QOL, and retinal microstructures were examined pre-treatment and 12 months post-treatment. The Titmus Stereo Test (TST) and TNO stereotest (TNO) were used to evaluate stereopsis. VR-QOL was evaluated using the 25-item National Eye Institute Visual Function Questionnaire (VFQ-25). IVR immediately and significantly improved the TST values, TNO values, composite VFQ-25 score, BCVA, and central foveal thickness in patients with CRVO. The 12-month post-treatment TST and TNO values were significantly worse in the CRVO group compared to those in the normal group. The baseline composite VFQ-25 score significantly correlated with the TST value. Multivariate analysis revealed significant associations between the 12-month post-treatment composite VFQ-25 score and the baseline and 12-month post-treatment TNO values. In conclusion, IVR immediately improved stereopsis in CRVO, albeit below normal levels. Stereopsis (not visual acuity) was associated with pre- and post-treatment VR-QOL in patients with CRVO.

scholarly journals Vision-Related Quality of Life and Subscale Items Following Intravitreal Ranibizumab Injections for Central Retinal Vein Occlusion

2021 ◽  
Author(s):  
Fumiki Okamoto ◽  
Tomoya Murakami ◽  
Yoshimi Sugiura ◽  
Shohei Morikawa ◽  
Takahiro Hiraoka ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Central Retinal Vein Occlusion ◽  
Visual Function ◽  
Intravitreal Ranibizumab ◽  
Vein Occlusion ◽  
Before And After ◽  
Related Quality ◽  
Normal Controls ◽  
Central Retinal Vein

Abstract The aim of this study was to evaluate the vision-related quality of life (VR-QOL) before and after intravitreal ranibizumab injections (IVR) for central retinal vein occlusion (CRVO) and investigate subscale items of VR-QOL in detail. This multicenter, open-label, prospective study included 23 patients with treatment naïve CRVO and 22 age-matched normal controls. VR-QOL was assessed by the 25-Item Visual Function Questionnaire (VFQ-25) before and up to 12 months post-treatment. The VFQ-25 composite score and 12 subscales were compared between groups. The VFQ-25 composite scores in CRVO showed significant improvement throughout the treatment period compared with those at the baseline. The VFQ-25 composite score before and after treatment in CRVO was significantly lower than that in normal controls. The subscale items, including general health, general vision, near activities, social functioning, mental health, role difficulties, dependency, and peripheral vision, in CRVO were significantly lower than those in the normal controls even after treatment. Vision-related QOL was low in patients with CRVO before treatment and improved with IVR. Even after treatment, the values of several subscale items were lower than those in normal controls. Patients with CRVO require treatment aimed at further improving visual function as well as social and psychological care.

Contrast sensitivity and quality of life following intravitreal ranibizumab injection for central retinal vein occlusion

2021 ◽  
pp. bjophthalmol-2021-319863
Author(s):  
Tomoya Murakami ◽  
Fumiki Okamoto ◽  
Yoshimi Sugiura ◽  
Shohei Morikawa ◽  
Yoshifumi Okamoto ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Contrast Sensitivity ◽  
Retinal Vein Occlusion ◽  
Central Retinal Vein Occlusion ◽  
Macular Oedema ◽  
Composite Score ◽  
Vein Occlusion ◽  
The Relationship ◽  
Central Retinal Vein

Synopsis/precisWe investigated the relationship between contrast sensitivity (CS) and vision-related quality of life (VR-QOL) in patients with central retinal vein occlusion following ranibizumab intravitreal injection; CS showed a stronger association with VR-QOL than visual acuity.Background/aimsTo investigate the relationship between CS, VR-QOL and optical coherence tomography (OCT) findings in patients with cystoid macular oedema secondary to central retinal vein occlusion (CRVO-CMO) following intravitreal injection of ranibizumab.MethodsThis was a multicentre, open-label, single-arm, prospective study. The study included 23 patients with CRVO-CMO who were followed up for 12 months after treatment. The best-corrected visual acuity (BCVA), letter contrast sensitivity (LCS) and OCT images were obtained every month. For VR-QOL assessment, the 25-item National Eye Institute Visual Function Questionnaire (VFQ-25) was administered to the patients before treatment and at 3, 6 and 12 months following treatment.ResultsThe LCS and VFQ-25 composite score improved significantly from baseline to 12 months following treatment. The multiple regression analysis revealed that the LCS of the affected eye and BCVA of the fellow eye were related to the VFQ-25 composite score following treatment. The LCS improvement showed a significant correlation with the improvement in the VFQ-25 composite score, whereas the BCVA improvement was not correlated with the improvement in the VFQ-25 composite score. Stepwise multiple regression analyses revealed that, at the time of macular oedema resolution, the distance between the external limiting membrane and retinal pigment epithelium (ELM-RPE) and average ganglion cell-inner plexiform layer (GCIPL) thickness were associated with LCS.ConclusionCS had a stronger association with VR-QOL than with BCVA in patients with CRVO-CMO. With the resolution of macular oedema, CS was associated with ELM-RPE thickness and average GCIPL thickness.

scholarly journals Relationship between metamorphopsia and inner retinal microstructure following intravitreal ranibizumab injection for branch retinal vein occlusion

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yoshimi Sugiura ◽  
Fumiki Okamoto ◽  
Tomoya Murakami ◽  
Shohei Morikawa ◽  
Takahiro Hiraoka ◽  
...  
Keyword(s):  
Macular Edema ◽  
Retinal Vein Occlusion ◽  
Branch Retinal Vein Occlusion ◽  
Post Treatment ◽  
Intravitreal Ranibizumab ◽  
Vein Occlusion ◽  
Treatment Naïve ◽  
Pre Treatment ◽  
Number Of Injections

AbstractTo evaluate the effects of intravitreal ranibizumab injection (IVR) on metamorphopsia in patients with branch retinal vein occlusion (BRVO), and to assess the relationship between metamorphopsia and inner retinal microstructure and other factors. Thirty-three treatment-naïve eyes of 33 patients with macular edema caused by BRVO with at least 12 months of follow-up were included. The degree of metamorphopsia was quantified using the M-CHARTS. Retinal microstructure was assessed with spectral-domain optical coherence tomography. Disorganization of the retinal inner layers (DRIL) at the first month after resolution of the macular edema (early DRIL) and at 12 months after treatment (after DRIL) was studied. Central retinal thickness (CRT), and status of the external limiting membrane as well as ellipsoid zone were also evaluated. IVR treatment significantly improved best-corrected visual acuity (BCVA) and CRT, but the mean metamorphopsia score did not improve even after 12 months. Post-treatment metamorphopsia scores showed a significant correlation with pre-treatment metamorphopsia scores (P < 0.005), the extent of early DRIL (P < 0.05) and after DRIL (P < 0.05), and the number of injections (P < 0.05). Multivariate analysis revealed that the post-treatment mean metamorphopsia score was significantly correlated with the pre-treatment mean metamorphopsia score (P < 0.05). IVR treatment significantly improved BCVA and CRT, but not metamorphopsia. Post-treatment metamorphopsia scores were significantly associated with pre-treatment metamorphopsia scores, the extent of DRIL, and the number of injections. Prognostic factor of metamorphopsia was the degree of pre-treatment metamorphopsia.

scholarly journals Near vision correction and quality of life among textile factory workers in Durban

2017 ◽  
Vol 76 (1) ◽  
Author(s):  
Ving F. Chan ◽  
Jyoti Naidoo ◽  
Farai S. Chinanayi ◽  
Kovin S. Naidoo
Keyword(s):  
Quality Of Life ◽  
Vision Impairment ◽  
Factory Workers ◽  
Near Vision ◽  
Related Quality ◽  
Visual Function Questionnaire ◽  
Pre Treatment ◽  
Textile Factory ◽  
Textile Factory Workers

Background: Uncorrected near vision impairment affects the performance of near vision tasks and activities for an estimated 410 million people worldwide. Once normal vision becomes blurred or impaired, the ordinary and simple daily routines of individuals become difficult; often resulting in frustration and irritation, which is consequently reflected in their quality of life.Aim: We investigated the change of vision-related quality of life (VRQoL) following near correction among textile factory workers in South Africa.Methods: Presbyopic subjects who were 40 years and older with no other eye conditions were provided near spectacle correction. We interviewed subjects to ascertain their VRQoL scores using the National Eye Institute Visual Function Questionnaire, pre-treatment and 6 months after the provision of near corrections.Setting: The study was conducted among the textile factory workers in KwaZulu-Natal, South Africa.Results: A total of 423 textile factory workers were followed up from seven textile factories in Durban. The overall increase in VRQoL scores of 21.9 (95% CI 16.7–27) was significant (p < 0.01). This translates to a 36.5% (95% CI 30.6–42.4) change in VRQoL. The increase was highest among participants of African origin 25.1 (95% CI 21.14–29.1), males 18.8 (95% CI 12.6–27.2), among those who had completed primary school 35.8 (95% CI 21.7–49.9) and among participants with other responsibilities (ironing and quality assurance) 21.9 (95% CI 16.7–27).Conclusion: Correcting near vision impairment improved the VRQoL scores of textile factory workers. The results showed that VRQoL scores increased significantly across levels of education and categories of responsibility

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