scholarly journals Preemptive Flupirtine in Patients Undergoing Laparoscopic Cholecystectomy for Postoperative Pain Management

2017 ◽  
Vol 4 (1) ◽  
Author(s):  
Asit Kumar Sethy
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Pain Management ◽  
Postoperative Pain ◽  
Postoperative Pain Management

scholarly journals Efficacy of methadone for the management of postoperative pain in laparoscopic cholecystectomy: A randomized clinical trial

Medwave ◽  
2021 ◽  
Vol 21 (02) ◽  
pp. e8134-e8134
Author(s):  
Nicolás Arriaza ◽  
Cristian Papuzinski ◽  
Matías Kirmayr ◽  
Marcelo Matta ◽  
Fernando Aranda ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Laparoscopic Cholecystectomy ◽  
Pain Management ◽  
Postoperative Pain ◽  
Randomized Clinical Trial ◽  
Postoperative Pain Management ◽  
Anesthesia Care ◽  
Post Anesthesia Care Unit ◽  
Methadone Group ◽  
Eye Opening

Background Postoperative pain management contributes to reducing postoperative morbidity and unscheduled readmission. Compared to other opioids that manage postoperative pain like morphine, few randomized trials have tested the efficacy of intraoperatively administered methadone to provide evidence for its regular use or be included in clinical guidelines. Methods We conducted a randomized clinical trial comparing the use of intraoperative methadone to assess its impact on postoperative pain. Eighty-six patients undergoing elective laparoscopic cholecystectomy were allocated to receive either methadone (0.08 mg/kg) or morphine (0.08 mg/kg). Results Individuals who received methadone required less rescue morphine in the Post Anesthesia Care Unit for postoperative pain than those who received morphine (p = 0.0078). The patients from the methadone group reported less pain at 5 and 15 minutes and 12 and 24 hours following Post Anesthesia Care Unit discharge, exhibiting fewer episodes of nausea. Time to eye-opening was equivalent between the two groups. Conclusion Intraoperative use of methadone resulted in better management of postoperative pain, supporting its use as part of a multimodal pain management strategy for laparoscopic cholecystectomy under remifentanil-based anesthesia.

Sign in / Sign up

Export Citation Format

Share Document