scholarly journals 1SI-05 A cellular funicular : one active force generation drives two directional organelle movements(1SI Exploring force-generating mechanism of molecular motor ensembles; building bridges between single molecules and cells,Symposium,The 50th Annual Meeting of the Biophysical Society of Japan)

2012 ◽  
Vol 52 (supplement) ◽  
pp. S9
Author(s):  
Akatsuki Kimura
Keyword(s):  
Annual Meeting ◽  
Molecular Motor ◽  
Single Molecules ◽  
Force Generation ◽  
Active Force ◽  
Biophysical Society ◽  
Active Force Generation

scholarly journals 3P-125 G146V mutation in actin inhibits force generation during interaction with skeletal myosin.(Molecular motor,The 47th Annual Meeting of the Biophysical Society of Japan)

2009 ◽  
Vol 49 (supplement) ◽  
pp. S172
Author(s):  
Taro Noguchi ◽  
Masatoshi Morimatsu ◽  
Kohji Ito ◽  
Atsuko Iwane ◽  
Toshio Yanagida ◽  
...  
Keyword(s):  
Annual Meeting ◽  
Molecular Motor ◽  
Force Generation ◽  
Biophysical Society ◽  
Skeletal Myosin

scholarly journals Active force generation shapes the metaphase spindle through a mechanical instability

2020 ◽  
Author(s):  
David Oriola ◽  
Frank Jülicher ◽  
Jan Brugués
Keyword(s):  
Liquid Crystal ◽  
Soft Matter ◽  
Molecular Motor ◽  
Dynamic Structure ◽  
Force Generation ◽  
Active Force ◽  
Mechanical Instability ◽  
Egg Extract ◽  
Active Liquid ◽  
Active Force Generation

The metaphase spindle is a dynamic structure that segregates chromosomes during cell division. Recently, soft matter approaches have shown that the spindle behaves as an active liquid crystal. Still, it remains unclear how active force generation contributes to its characteristic spindle-like shape. Here, we combine theory and experiments to show that molecular motor driven forces shape the structure through a barreling-type instability. We test our physical model by titrating dynein activity in Xenopus egg extract spindles and quantifying the shape and microtubule orientation. We conclude that spindles are shaped by the interplay between surface tension, nematic elasticity and motor-driven active forces. Our study reveals how active force generation can mold liquid crystal droplets and it has implications on the morphology of non-membrane bound compartments demixed from the cytoplasm.

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