Critical COVID-19 Pneumonia with Acute Respiratory Failure in a Healthy 12-year-old Girl

The authors present a case report of an otherwise healthy, fully immunized 12-year-old girl who had a critical course of COVID-19 infection with acute respiratory failure. The epidemiologic history was positive for COVID-19, and she tested PCR positive resulting from a nasopharyngeal swab. She was presented with fever and cough to a regional pediatric department, and she was immediately intubated and transferred to a pediatric ICU in a University Hospital. CT of the thorax revealed bilateral consolidation with the tree-in-bud signs. Her condition required artificial ventilation support for 13 days. Remdesivir, pronation, high dose Ascorbic acid with Thiamine, and combined antimicrobial therapy were successfully used. The patient made a full clinical recovery. This case report is unique because of a very scarce critical course of COVID-19 infection in children. It demonstrates the successful use of a combined therapeutic approach with artificial ventilation, pronation, Remdesivir, and combined antimicrobial therapy. Clinical symptoms, laboratory results, imaging methods, and therapeutic attitude are mentioned to share our experience with the medical community.

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Critical COVID-19 Pneumonia with Acute Respiratory Failure in a Healthy 12-year-old Girl

10.21467/preprints.325 ◽

2021 ◽

Author(s):

Karolina Dolezalova ◽

Cabelova Tamara ◽

Tomas Hecht ◽

Pavel Heinige

Keyword(s):

Intensive Care Unit ◽

Respiratory Failure ◽

Acute Respiratory Failure ◽

Paediatric Intensive Care Unit ◽

Artificial Ventilation ◽

Medical Community ◽

Nasopharyngeal Swab ◽

High Dose ◽

Clinical Recovery ◽

Ventilation Support

We present an otherwise healthy, fully immunized 12-year-old girl who was transferred intubated and ventilated to our Paediatric Intensive Care Unit with fever, cough, and acute respiratory failure. The epidemiologic history was positive for COVID-19, and, furthermore, she tested PCR positive resulting from a nasopharyngeal swab. CT of the thorax revealed bilateral consolidation with the tree-in-bud signs. Her condition required artificial ventilation support for 13 days. Remdesivir, pronation, high dose Ascorbic acid with Thiamine, and combined antimicrobial therapy were successfully used. Our patient made a full clinical recovery. The case demonstrates that even though critical course of COVID-19 infection in children is scarce, it might occur. We hereby would like to share our experience with the medical community.

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A strange case of severe but fleeting hypoxemia in patient with COVID-19 infection: maybe virus-induced pulmonary Raynaud’s phenomenon?

Monaldi Archives for Chest Disease ◽

10.4081/monaldi.2021.1706 ◽

2021 ◽

Vol 91 (2) ◽

Author(s):

Nicola Barbarito

Keyword(s):

Case Report ◽

Respiratory Failure ◽

Acute Respiratory Failure ◽

Raynaud’S Phenomenon ◽

Raynaud's Phenomenon ◽

Nasopharyngeal Swab

This case-report describes severe acute respiratory failure in a patient with a COVID-19 positive nasopharyngeal swab that spontaneously resolved within a few hours. It is speculated that the virus may have caused a fleeting pulmonary vasospasm.

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Acute respiratory failure as presentation of late-onset Pompe disease complicating the diagnostic process as a labyrinth: a case report

Multidisciplinary Respiratory Medicine ◽

10.1186/s40248-018-0145-4 ◽

2018 ◽

Vol 13 (1) ◽

Cited By ~ 1

Author(s):

Francesco Menzella ◽

Luca Codeluppi ◽

Mirco Lusuardi ◽

Carla Galeone ◽

Franco Valzania ◽

...

Keyword(s):

Case Report ◽

Respiratory Failure ◽

Acute Respiratory Failure ◽

Pompe Disease ◽

Late Onset ◽

Diagnostic Process

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Urgent Lung Transplantation in Severe Acute Respiratory Failure Based on Rapidly Progressive Interstitial Lung Disease: A Case Report

Transplantation Proceedings ◽

10.1016/j.transproceed.2017.06.020 ◽

2017 ◽

Vol 49 (7) ◽

pp. 1544-1548 ◽

Cited By ~ 3

Author(s):

I. Madurka ◽

J. Elek ◽

N. Schönauer ◽

T. Bartók ◽

K. Kormosói-Tóth ◽

...

Keyword(s):

Case Report ◽

Respiratory Failure ◽

Interstitial Lung Disease ◽

Acute Respiratory Failure ◽

Lung Transplantation ◽

Lung Disease

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Acute respiratory failure as presentation of late-onset Pompe disease complicating the diagnostic process as a labyrinth: a case report

Multidisciplinary Respiratory Medicine ◽

10.4081/mrm.2018.176 ◽

2018 ◽

Vol 13 ◽

Author(s):

Francesco Menzella ◽

Luca Codeluppi ◽

Mirco Lusuardi ◽

Carla Galeone ◽

Franco Valzania ◽

...

Keyword(s):

Case Report ◽

Respiratory Failure ◽

Acute Respiratory Failure ◽

Pompe Disease ◽

Late Onset ◽

Correct Diagnosis ◽

Ventilatory Support ◽

Diagnostic Process ◽

Caucasian Woman ◽

Enzyme Replacement

Background: Acute respiratory failure can be triggered by several causes, either of pulmonary or extra-pulmonary origin. Pompe disease, or type II glycogen storage disease, is a serious and often fatal disorder, due to a pathological accumulation of glycogen caused by a defective activiy of acid α-glucosidase (acid maltase), a lysosomal enzyme involved in glycogen degradation. The prevalence of the disease is estimated between 1 in 40,000 to 1 in 300,000 subjects. Case presentation: This case report describes a difficult diagnosis of late-onset Pompe disease (LOPD) in a 52 year old Caucasian woman with acute respiratory failure requiring orotracheal intubation and subsequent tracheostomy for long-term mechanical ventilation 24 h/day. Despite a complex diagnostic process including several blood tests, bronchoscopy with BAL, chest CT, brain NMR, electromyographies, only a muscle biopsy allowed to reach the correct diagnosis. Discussion: The most frequent presentation of myopathies, including LOPD, is proximal limb muscle weakness. Respiratory related symptoms (dyspnea on effort, reduced physical capacity, recurrent infections, etc.) and respiratory failure are often evident in the later stages of the diseases, but they have been rarely described as the onset symptoms in LOPD. In our case, a third stage LOPD, the cooperation between pulmonologists and neurologists was crucial in reaching a correct diagnosis despite a very complex clinical scenario due to different confounding co-morbidities as potential causes of respiratory failure and an atypical presentation. In this patient, enzyme replacement therapy with infusion of alglucosidase alfa was associated with progressive reduction of ventilatory support to night hours, and recovery of autonomous walking.

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Drowning induced acute respiratory failure: A case report

International Journal of Case Reports and Images ◽

10.5348/100939z01st2018cr ◽

2018 ◽

Vol 9 ◽

pp. 1

Author(s):

Houari Nawfal ◽

Elbouazzaoui Abderrahim ◽

Boukatta Brahim ◽

Kanjaa Nabil

Keyword(s):

Case Report ◽

Respiratory Failure ◽

Acute Respiratory Failure

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Acute Respiratory Failure in a Regional Respiratory Unit

Anaesthesia and Intensive Care ◽

10.1177/0310057x7700500412 ◽

1977 ◽

Vol 5 (4) ◽

pp. 372-377 ◽

Cited By ~ 3

Author(s):

O. F. James ◽

R. M. Mills ◽

K. Murree Allen

Keyword(s):

Respiratory Failure ◽

Acute Respiratory Failure ◽

Artificial Ventilation

One thousand, six hundred and sixteen patients with acute respiratory failure were managed in a regional respiratory unit. The patients are classified according to cause, the need for artificial ventilation and results.

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