<p>Intraocular Pressure Calculation in Myopic Patients After Laser-Assisted In Situ Keratomileusis</p>

Abstract Glaucoma is an ocular disease i.e. more common in older adults with elevated intraocular pressure and a serious threat to vision if it is not controlled. Due to the limitations regarding the conventional form of brinzolamide (Azopt®), two optimum formulations of in situ gel nanoemulsion were developed. To ensure the safety and efficacy of developed formulations for ocular drug delivery, the current study was designed. MTT assay was carried out on the human retinal pigmentation epithelial cells. To investigate the irritation potential of the chosen formulations, hen’s egg test-chorioallantoic membrane as a borderline test between in vivo and in vitro methods has been done. The modified Draize method was utilized to evaluate eye tolerance against the selected formulations. Intraocular pressure was measured by applying the prepared formulations to the eyes of normotensive albino rabbits in order to assess the therapeutic efficacy. Based on MTT test, cell viability for NE-2 at 0.1% and NE-1 at 0.1 and 0.5% concentrations was acceptable. The results of the hen’s egg test-chorioallantoic membrane test indicated no sign of vessel injury on the chorioallantoic membrane surface for both formulations. Also, during 24 h, both formulations were well-tolerated by rabbit eyes. The pharmacodynamics effects of formulations had no difference or were even higher than that of suspension in case of adding lower concentration (0.5%) of brinzolamide to the formulations. With regard to the results of the mentioned methods, our advanced formulations were effective, safe, and well-tolerated, thus can be introduced as an appropriate vehicle for ocular delivery of brinzolamide.

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Changes in biomechanically corrected intraocular pressure and dynamic corneal response parameters before and after transepithelial photorefractive keratectomy and femtosecond laser–assisted laser in situ keratomileusis

Journal of Cataract & Refractive Surgery ◽

10.1016/j.jcrs.2017.08.019 ◽

2017 ◽

Vol 43 (12) ◽

pp. 1495-1503 ◽

Cited By ~ 17

Author(s):

Hun Lee ◽

Cynthia J. Roberts ◽

Tae-im Kim ◽

Renato Ambrósio ◽

Ahmed Elsheikh ◽

...

Keyword(s):

Intraocular Pressure ◽

Femtosecond Laser ◽

Laser In Situ Keratomileusis ◽

Photorefractive Keratectomy ◽

Before And After

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Correlation of intraocular pressure and central corneal thickness in normal myopic eyes and after laser in situ keratomileusis

Journal of Cataract & Refractive Surgery ◽

10.1016/s0886-3350(98)80222-8 ◽

1998 ◽

Vol 24 (10) ◽

pp. 1320-1325 ◽

Cited By ~ 88

Author(s):

Barry Emara ◽

Louis E. Probst ◽

David P. Tingey ◽

Dennis W. Kennedy ◽

Lisa J. Willms ◽

...

Keyword(s):

Intraocular Pressure ◽

Central Corneal Thickness ◽

Corneal Thickness ◽

Laser In Situ Keratomileusis

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Transient keratectasia caused by intraocular pressure elevation after laser in situ keratomileusis

Journal of Cataract & Refractive Surgery ◽

10.1016/j.jcrs.2004.08.046 ◽

2005 ◽

Vol 31 (1) ◽

pp. 202-204 ◽

Cited By ~ 21

Author(s):

Atsuko Toshino ◽

Toshihiko Uno ◽

Yuichi Ohashi ◽

Naoyuki Maeda ◽

Tetsuro Oshika

Keyword(s):

Intraocular Pressure ◽

Laser In Situ Keratomileusis ◽

Pressure Elevation ◽

Intraocular Pressure Elevation

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Comparison of Intraocular Pressure before and after Laser In Situ Keratomileusis Refractive Surgery Measured with Perkins Tonometry, Noncontact Tonometry, and Transpalpebral Tonometry

Journal of Ophthalmology ◽

10.1155/2015/683895 ◽

2015 ◽

Vol 2015 ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

Isabel Cacho ◽

Juan Sanchez-Naves ◽

Laura Batres ◽

Jesús Pintor ◽

Gonzalo Carracedo

Keyword(s):

Intraocular Pressure ◽

Refractive Surgery ◽

Corneal Thickness ◽

Laser In Situ Keratomileusis ◽

Spherical Equivalent ◽

Transpalpebral Tonometry ◽

Spherical Equivalent Refraction ◽

Before And After ◽

Noncontact Tonometry

Purpose. To compare the intraocular pressure (IOP) before and after Laser In Situ Keratomileusis (LASIK), measured by Diaton, Perkins, and noncontact air pulse tonometers.Methods. Fifty-seven patients with a mean age of 34.88 were scheduled for myopia LASIK treatment. Spherical equivalent refraction (SER), corneal curvature (K), and central corneal thickness (CCT) and superior corneal thickness (SCT) were obtained before and after LASIK surgery. IOP values before and after surgery were measured using Diaton, Perkins, and noncontact air pulse tonometers.Results. The IOP values before and after LASIK surgery using Perkins tonometer and air tonometers were statistically significant (p<0.05). However, no significant differences were found (p>0.05) for IOP values measured with Diaton tonometer. CCT decreases significantly after surgery (p<0.05) but no statistical differences were found in SCT (p=0.08). Correlations between pre- and postsurgery were found for all tonometers used, withp=0.001andr=0.434for the air pulse tonometer,p=0.008andr=0.355for Perkins, andp<0.001andr=0.637for Diaton.Conclusion. Transpalpebral tonometry may be useful for measuring postsurgery IOP after myopic LASIK ablation because this technique is not influenced by the treatment.

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