scholarly journals Early Study of Tumor Abnormal Protein in Gastric Adenocarcinoma

2021 ◽  
Vol Volume 14 ◽  
pp. 1719-1726
Author(s):  
Ming Zhang ◽  
Xiaoyu Wang ◽  
Zhenghua Wang
Keyword(s):  
Gastric Adenocarcinoma ◽  
Abnormal Protein

Nitric oxide synthase and cyclooxygenase expressions in different stages of human gastric adenocarcinoma

2001 ◽  
Vol 120 (5) ◽  
pp. A169-A169 ◽  
Author(s):  
A RAJNAKOVA ◽  
P GOH ◽  
S NGOI ◽  
S MOOCHHALA ◽  
S LIM
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Gastric Adenocarcinoma ◽  
Human Gastric Adenocarcinoma ◽  
Oxide Synthase

Abstract #403: Severe Hypoglycemia in a Patient with Gastric Adenocarcinoma: An IGF-II Secreting Tumor?

2016 ◽  
Vol 22 ◽  
pp. 108-109
Author(s):  
Morgan Jones ◽  
Kathie Hermayer-Dawson
Keyword(s):  
Gastric Adenocarcinoma ◽  
Severe Hypoglycemia

GASTRIC ADENOCARCINOMA OF FUNDIC GLAND TYPE: CLINICOPATHOLOGICAL FEATURES DETERMINED BY RETROSPECTIVE ANALYSIS

2018 ◽  
Author(s):  
S Shiroma ◽  
T Hirasawa ◽  
M Takamatsu ◽  
H Kawachi ◽  
S Yoshimizu ◽  
...  
Keyword(s):  
Retrospective Analysis ◽  
Gastric Adenocarcinoma ◽  
Clinicopathological Features ◽  
Fundic Gland ◽  
Gland Type

Helical CT Findings of Gastric Wall Thickening by Peptic Ulcer: Compared with Gastric Adenocarcinoma with Ulcer

2000 ◽  
Vol 42 (2) ◽  
pp. 281
Author(s):  
Won Jung Jung ◽  
Jong Chul Choi ◽  
Keum Soo Seo ◽  
Bon Sik Koo ◽  
Byeong Ho Park ◽  
...  
Keyword(s):  
Peptic Ulcer ◽  
Gastric Adenocarcinoma ◽  
Gastric Wall ◽  
Helical Ct ◽  
Wall Thickening ◽  
Ct Findings

HER2 OVEREXPRESSION IN ENDOSCOPIC BIOPSY SAMPLE OF GASTRIC ADENOCARCINOMA BY IMMUNOHISTOCHEMISTRY

2012 ◽  
pp. 109-118
Author(s):  
Viet Nho Le ◽  
Van Huy Tran ◽  
Cong Thuan Dang ◽  
Van To Ta
Keyword(s):  
Gastric Adenocarcinoma ◽  
Undifferentiated Carcinoma ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Endoscopic Biopsy ◽  
Her2 Overexpression ◽  
Tubular Adenocarcinoma ◽  
Signet Ring ◽  
Poorly Differentiated ◽  
Well Differentiated

Background and aim: HER2 overexpression by immunohistochemistry is a prognostic maker in gastric cancer and helps to select candidates benefitted from targeted therapy with trastuzumab. This study is aimed at the assessing HER2 overexpression and its relationship with endoscopic and histopathological findings of gastric adenocarcinoma. Objectives and methods: Biopsy samples from 92 gastric cancer patients were examined for HER2 status by immunohistochemical staining. Results: 6.5% of tumors were cardia tumors and 93.5% were non-cardia tumors. Using the Lauren classification, 51.1% were intestinal type and 48.9% were diffuse type. Using WHO classification, 54.3% were tubular adenocarcinoma, 7.6% were mucinous adenocarcinoma, 15.2% were signet-ring cell carcinoma, and 22.8% were undifferentiated carcinoma. 32.6% were well-differentiated, 15.2% were moderately-differentiated, and 52.2% were poorly-differentiated carcinoma. HER2 was positive in 20.7% of gastric carcinomas, 50% cardia tumors and 18.6% non-cardia tumors. HER2 positivity among polypoid, fungating, ulcerated, and infiltrative types were 38.5%, 29.7%, 9.1% and 0%, respectively. HER2 overexpression in intestinal type was higher than that in diffuse type (31.9% vs. 8.9%, p = 0.009). HER2 overexpression in tubular adenocarcinoma, mucinous adenocarcinoma, signet-ring cell carcinoma, and undifferentiated carcinoma was 28.0%, 14.3%, 7.1% and 14.3%, respectively. HER2 overexpressions were different between differentiation degrees: 30% of well-differentiated tumors, 35.7% moderately-differentiated tumors, and 10.4% of poorly-differentiated tumors (p = 0.037). Conclusions: HER2 overexpression was found in 20.7% of endoscopic biopsy sample of gastric adenocarcinoma and was associated with endoscopic gross characteristic, Lauren histologic type and differentiation degree.

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