Retrospective Analysis
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2021 ◽  
Yue Sun ◽  
Dai-Feng Li ◽  
Yin-Li Zhang ◽  
Liang Xu ◽  
Tian-Fang Li

Abstract Objectives To study the characteristics and prognosis of dermatomyositis (DM) with different initial symptoms. Patients and methods: A retrospective analysis was performed on the patients who were first diagnosed with DM from 1 Jan. 2019 to 1 Jan. 2021. According to different initial symptoms, patients were divided into five groups, including rash, myasthenia, arthritis, respiratory symptom and atypical symptom group. Clinical and laboratory data were recorded. All patients were followed up until 31st May 2021. Results In total 136 patients, rash (40%) was the most common initial symptoms of DM, followed by respiratory symptoms (22%), arthritis (20%), muscle weakness (10%) and atypical symptoms (8%). Rash groups and atypical groups had a higher positive rate of anti-TIF1γ antibodies than arthritis groups and respiratory symptom groups (P < 0.05). Respiratory symptom and arthritis groups had a higher positive rate of anti-Ro52 antibodies than rash and myasthenia groups (P < 0.05). Respiratory groups had a higher incidence of ILD than rash and atypical groups. The FVC and DLCO in respiratory group were significantly lower than rash, arthritis and atypical groups (P < 0.05). The 3-year survival rate of rash groups was significantly higher than myasthenia groups and arthritis groups (P < 0.05). Conclusions DM patients with different initial manifestations had different pulmonary function tests, myositis antibodies and prognosis.

2021 ◽  
Vol 2 (2) ◽  
pp. 124-129
Jamila Rida ◽  
Houda Moubachir ◽  
Youssef Bouchriti

Asthma is a serious public health problem. This study aimed to identify the characteristics of asthma cases reported by Agadir's Souss-Massa Regional Hospital Center (SMRHC). A retrospective analysis was carried out at the SMRHC's pneumology and paediatrics departments in 2019. As data support, reporting records and a data collection worksheet were used. This year, 141 cases were reported. The highest frequencies were observed in February (21.9%) and April (26.6%). Both males and females were affected (sex ratio Male/Female = 0.98). The asthmatics were, on average 40.7 ± 25.1 years old. The majority of the cases are from areas that are easily accessible for medical consultation at the SMRHC. To obtain more accurate knowledge and contribute to the research, related studies should be undertaken on this topic. Our findings, we hope, will act as a foundation for future research into improving the case registration system (digital support) and upgrading patient data in accordance with WHO and GINA guidelines.

2021 ◽  
Vol 22 (12) ◽  
pp. 660-670
V. V. Kosyanchuk ◽  
E. Yu. Zybin ◽  
V. V. Glasov ◽  
L. Tan

The article is devoted to the development of algorithms for predicting the trajectory of maneuvering objects based on nonparametric systems theory. The analysis of uncertainties affecting the modeling of the movement maneuvering water objects is presented. An overview of parametric, nonparametric and combined methods for predicting maneuvering water objects trajectory is given. The problem of high-precision autonomous control of the landing unmanned aerial vehicles on the landing vessel in the conditions of its irregular movement caused by meteorological conditions and active maneuvering is being solved. The method for predicting the trajectory of a vessel’s movement based on solving direct problems of dynamics using nonparametric systems theory is proposed. The advantages of the proposed method are that it’s not affected by model errors, due to the fact that it is based only on a retrospective analysis of several consecutive values of the spatial vessel coordinates. The proposed method differs from similar nonparametric methods in that it does not require statistical calculations, own training, or time-consuming tuning. The method does not imply the solution of identification model parameters, state and control actions problems and can be applied with any unknown linearizable input control actions, including when the model of the vessel’s motion dynamics is not identifiable. The results of numerical modeling for solution the problem of predicting the trajectory of an actively maneuvering small-sized landing vessel using a full nonlinear dynamic model with six degrees of freedom are presented. The studies carried out confirm the efficiency, adequacy and very fast adjustment of the developed method under conditions of complete parametric and nonparametric uncertainty. The proposed method can be used to predict the trajectory of any vehicle under the condition of linearizability of its model and control signals over the observed time interval.

2021 ◽  
Vol 11 ◽  
Ajay Gogia ◽  
Sukesh Nair ◽  
Shalabh Arora ◽  
Lalit Kumar ◽  
Atul Sharma ◽  

IntroductionThere is a scarcity of data from India on the impact of cell of origin (COO) on outcomes of diffuse large B-cell lymphoma (DLBCL). This study was conducted to evaluate the impact of COO on outcomes of DLBCL patients treated with uniform rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (RCHOP) protocol.Materials and MethodsThis retrospective analysis included patients who received uniform RCHOP chemoimmunotherapy during the study period (2014–2020) at the Department of Medical Oncology at All India Institute of Medical Sciences (AIIMS), New Delhi, India. The patients were classified as germinal center B-cell like (GCB) or activated B-cell (ABC) type using the Hans classification.ResultsFour hundred seventeen patients with median age of 48 years (range, 18–76) and a male-female ratio of 2:1 were included in the analysis. B symptoms and bulky disease were seen in 42.9% and 35.5%. Extranodal involvement was seen in 50.8% of cases. ECOG performance status (0-2) was present in 65%, and 51% presented with advanced disease. GCB subtype was seen in 43%, and 47% were ABC type. Low- and intermediate-risk international prognostic index (IPI) score was seen in 76% of cases. The overall response rate to RCHOP was 85.8%, including a complete response rate of 74.8%. After a median follow-up of 30 months, the 3-year event-free survival (EFS) and overall survival (OS) were 80% and 88%, respectively. The presence of B symptoms and poor ECOG performance status (3-4) was associated with inferior CR rate. Low albumin (p &lt; 0.001), age &gt;60 years (p = 0.001), bulky disease (p &lt; 0.001), and extranodal involvement (p = 0.001) were associated with inferior EFS, whereas a high IPI risk score was associated with an inferior OS (p &lt; 0.001). EFS and OS were not significantly different between the GCB and ABC subtypes. Grade III/IV anemia, neutropenia, and thrombocytopenia were seen in 7.6%, 13.6%, and 2.7% of patients, respectively. Febrile neutropenia was seen in 8.9% of patients, and there were four treatment-related deaths.ConclusionsCell of origin for DLBCL has no impact on CR, EFS, and OS if patients are appropriately treated with standard doses and frequency of RCHOP. RCHOP is well tolerated in our patients, and results are comparable with the Western data.

Eric O. Yeates ◽  
Areg Grigorian ◽  
Morgan Schellenberg ◽  
Natthida Owattanapanich ◽  
Galinos Barmparas ◽  

Abstract Purpose The COVID-19 pandemic resulted in increased penetrating trauma and decreased length of stay (LOS) amongst the adult trauma population, findings important for resource allocation. Studies regarding the pediatric trauma population are sparse and mostly single-center. This multicenter study examined pediatric trauma patients, hypothesizing increased penetrating trauma and decreased LOS after the 3/19/2020 stay-at-home (SAH) orders. Methods A multicenter retrospective analysis of trauma patients ≤ 17 years old presenting to 11 centers in California was performed. Demographic data, injury characteristics, and outcomes were collected. Patients were divided into three groups based on injury date: 3/19/2019–6/30/2019 (CONTROL), 1/1/2020–3/18/2020 (PRE), 3/19/2020–6/30/2020 (POST). POST was compared to PRE and CONTROL in separate analyses. Results 1677 patients were identified across all time periods (CONTROL: 631, PRE: 479, POST: 567). POST penetrating trauma rates were not significantly different compared to both PRE (11.3 vs. 9.0%, p = 0.219) and CONTROL (11.3 vs. 8.2%, p = 0.075), respectively. POST had a shorter mean LOS compared to PRE (2.4 vs. 3.3 days, p = 0.002) and CONTROL (2.4 vs. 3.4 days, p = 0.002). POST was also not significantly different than either group regarding intensive care unit (ICU) LOS, ventilator days, and mortality (all p > 0.05). Conclusions This multicenter retrospective study demonstrated no difference in penetrating trauma rates among pediatric patients after SAH orders but did identify a shorter LOS.

2021 ◽  
Vol 15 ◽  
Liliana da Conceição Teixeira ◽  
Danielle Blacker ◽  
Carlos Campos ◽  
Carolina Garrett ◽  
Sophie Duport ◽  

Purpose: The recommended way to assess consciousness in prolonged disorders of consciousness is to observe the patient’s responses to sensory stimulation. Multiple assessment sessions have to be completed in order to reach a correct diagnosis. There is, however, a lack of data on how many sessions are sufficient for validity and reliability. The aim of this study was to identify the number of Sensory Modality Assessment and Rehabilitation Technique (SMART) assessment sessions needed to reach a reliable diagnosis. A secondary objective was to identify which sensory stimulation modalities are more useful to reach a diagnosis.Materials and Methods: A retrospective analysis of all the adult patients (who received a SMART assessment) admitted to a specialist brain injury unit over the course of 4 years was conducted (n = 35). An independent rater analyzed the SMART levels for each modality and session and provided a suggestive diagnosis based on the highest SMART level per session.Results: For the vast majority of patients between 5 and 6 sessions was sufficient to reach the final clinical diagnosis. The visual, auditory, tactile, and motor function modalities were found to be more associated with the final diagnosis than the olfactory and gustatory modalities.Conclusion: These findings provide for the first time a rationale for optimizing the time spent on assessing patients using SMART.

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