scholarly journals Parasite Prolyl Oligopeptidases and the Challenge of Designing Chemotherapeuticals for Chagas Disease, Leishmaniasis and African Trypanosomiasis

2013 ◽  
Vol 999 (999) ◽  
pp. 21-25 ◽  
Author(s):  
I.M.D. Bastos ◽  
F.N. Motta ◽  
P. Grellier ◽  
J.M. Santana
Keyword(s):  
Chagas Disease ◽  
African Trypanosomiasis ◽  
Prolyl Oligopeptidases

Thiazole, thio and semicarbazone derivatives against tropical infective diseases: Chagas disease, human African trypanosomiasis (HAT), leishmaniasis, and malaria

2019 ◽  
Vol 162 ◽  
pp. 378-395 ◽  
Author(s):  
Cauê Benito Scarim ◽  
Daniela Hartmann Jornada ◽  
Marcella Gabrielle Mendes Machado ◽  
Carla Maria Riberio Ferreira ◽  
Jean Leandro dos Santos ◽  
...  
Keyword(s):  
Chagas Disease ◽  
Human African Trypanosomiasis ◽  
African Trypanosomiasis

scholarly journals Application of Dithiocarbamates as Potential New Antitrypanosomatids-Drugs: Approach Chemistry, Functional and Biological

Molecules ◽  
2019 ◽  
Vol 24 (15) ◽  
pp. 2806 ◽  
Author(s):  
Johny Wysllas de Freitas Oliveira ◽  
Hugo Alexandre Oliveira Rocha ◽  
Wendy Marina Toscano Queiroz de Medeiros ◽  
Marcelo Sousa Silva
Keyword(s):  
Chagas Disease ◽  
Biomedical Applications ◽  
In Vitro Models ◽  
African Trypanosomiasis ◽  
Pharmacological Activities ◽  
Antifungal Activities ◽  
Pharmacological Control

Dithiocarbamates represent a class of compounds that were evaluated in different biomedical applications because of their chemical versatility. For this reason, several pharmacological activities have already been attributed to these compounds, such as antiparasitic, antiviral, antifungal activities, among others. Therefore, compounds that are based on dithiocarbamates have been evaluated in different in vivo and in vitro models as potential new antimicrobials. Thus, the purpose of this review is to present the possibilities of using dithiocarbamate compounds as potential new antitrypanosomatids-drugs, which could be used for the pharmacological control of Chagas disease, leishmaniasis, and African trypanosomiasis.

scholarly journals An Overview on Target-Based Drug Design against Kinetoplastid Protozoan Infections: Human African Trypanosomiasis, Chagas Disease and Leishmaniases

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4629
Author(s):  
Violeta Kourbeli ◽  
Eleni Chontzopoulou ◽  
Kalliopi Moschovou ◽  
Dimitrios Pavlos ◽  
Thomas Mavromoustakos ◽  
...  
Keyword(s):  
Drug Design ◽  
Chagas Disease ◽  
Human African Trypanosomiasis ◽  
Neglected Diseases ◽  
African Trypanosomiasis ◽  
Special Issue ◽  
Design Synthesis ◽  
Drug Candidates ◽  
Leishmania Spp ◽  
Protozoan Infections

The protozoan diseases Human African Trypanosomiasis (HAT), Chagas disease (CD), and leishmaniases span worldwide and therefore their impact is a universal concern. The present regimen against kinetoplastid protozoan infections is poor and insufficient. Target-based design expands the horizon of drug design and development and offers novel chemical entities and potential drug candidates to the therapeutic arsenal against the aforementioned neglected diseases. In this review, we report the most promising targets of the main kinetoplastid parasites, as well as their corresponding inhibitors. This overview is part of the Special Issue, entitled “Advances of Medicinal Chemistry against Kinetoplastid Protozoa (Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp.) Infections: Drug Design, Synthesis and Pharmacology”.

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