biomedical applications
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2022 ◽  
Vol 151 ◽  
pp. 106931
Diganta Rabha ◽  
Muzamil Ahmad Rather ◽  
Manabendra Mandal ◽  
Pabitra Nath

2022 ◽  
Vol 30 ◽  
pp. 103048
O.V. Rybalchenko ◽  
N.Yu. Anisimova ◽  
M.V. Kiselevsky ◽  
G.V. Rybalchenko ◽  
N.S. Martynenko ◽  

2022 ◽  
Vol 204 ◽  
pp. 112045
Pooja Hariharan ◽  
Sujithra Sundarrajan ◽  
G. Arthanareeswaran ◽  
Sunanda Seshan ◽  
Diganta B. Das ◽  

2022 ◽  
Vol 141 ◽  
pp. 107421
Wei Yang ◽  
Shujie Pang ◽  
Ying Liu ◽  
Qing Wang ◽  
Peter K. Liaw ◽  

Nanomaterials ◽  
2022 ◽  
Vol 12 (2) ◽  
pp. 277
Miral Al Sharabati ◽  
Rana Sabouni ◽  
Ghaleb A. Husseini

Metal−organic frameworks (MOFs) are a novel class of porous hybrid organic−inorganic materials that have attracted increasing attention over the past decade. MOFs can be used in chemical engineering, materials science, and chemistry applications. Recently, these structures have been thoroughly studied as promising platforms for biomedical applications. Due to their unique physical and chemical properties, they are regarded as promising candidates for disease diagnosis and drug delivery. Their well-defined structure, high porosity, tunable frameworks, wide range of pore shapes, ultrahigh surface area, relatively low toxicity, and easy chemical functionalization have made them the focus of extensive research. This review highlights the up-to-date progress of MOFs as potential platforms for disease diagnosis and drug delivery for a wide range of diseases such as cancer, diabetes, neurological disorders, and ocular diseases. A brief description of the synthesis methods of MOFs is first presented. Various examples of MOF-based sensors and DDSs are introduced for the different diseases. Finally, the challenges and perspectives are discussed to provide context for the future development of MOFs as efficient platforms for disease diagnosis and drug delivery systems.

Molecules ◽  
2022 ◽  
Vol 27 (2) ◽  
pp. 537
Philippe Savarino ◽  
Emmanuel Colson ◽  
Guillaume Caulier ◽  
Igor Eeckhaut ◽  
Patrick Flammang ◽  

Saponins are plant and marine animal specific metabolites that are commonly considered as molecular vectors for chemical defenses against unicellular and pluricellular organisms. Their toxicity is attributed to their membranolytic properties. Modifying the molecular structures of saponins by quantitative and selective chemical reactions is increasingly considered to tune the biological properties of these molecules (i) to prepare congeners with specific activities for biomedical applications and (ii) to afford experimental data related to their structure–activity relationship. In the present study, we focused on the sulfated saponins contained in the viscera of Holothuria scabra, a sea cucumber present in the Indian Ocean and abundantly consumed on the Asian food market. Using mass spectrometry, we first qualitatively and quantitatively assessed the saponin content within the viscera of H. scabra. We detected 26 sulfated saponins presenting 5 different elemental compositions. Microwave activation under alkaline conditions in aqueous solutions was developed and optimized to quantitatively and specifically induce the desulfation of the natural saponins, by a specific loss of H2SO4. By comparing the hemolytic activities of the natural and desulfated extracts, we clearly identified the sulfate function as highly responsible for the saponin toxicity.

Small ◽  
2022 ◽  
pp. 2106263
Chao Gao ◽  
Ye Feng ◽  
Daniela A. Wilson ◽  
Yingfeng Tu ◽  
Fei Peng

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