Biomedical Applications
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Foroozan Yousefpour ◽  
Roohollah Jamaati ◽  
Hamed Jamshidi Aval

2021 ◽  
Vol 274 ◽  
pp. 115491
Amany M. El Nahrawy ◽  
Bahaa A. Hemdan ◽  
A.M. Mansour ◽  
Amir Elzwawy ◽  
Ali B. Abou Hammad

2021 ◽  
Vol 28 (11) ◽  
Irina Popescu ◽  
Mihail Lupei ◽  
Marieta Constantin ◽  
Geanina Voicu ◽  
Manuela Calin ◽  

ACS Nano ◽  
2021 ◽  
Hui Chen ◽  
Huimin Zhang ◽  
Tiantian Xu ◽  
Jiangfan Yu

2021 ◽  
Vol 17 ◽  
pp. 2553-2569
Luke O Jones ◽  
Leah Williams ◽  
Tasmin Boam ◽  
Martin Kalmet ◽  
Chidubem Oguike ◽  

Cryogels are macroporous polymeric structures formed from the cryogelation of monomers/polymers in a solvent below freezing temperature. Due to their inherent interconnected macroporosity, ease of preparation, and biocompatibility, they are increasingly being investigated for use in biomedical applications such as 3D-bioprinting, drug delivery, wound healing, and as injectable therapeutics. This review highlights the fundamentals of macroporous cryogel preparation, cryogel properties that can be useful in the highlighted biomedical applications, followed by a comprehensive review of recent studies in these areas. Research evaluated includes the use of cryogels to combat various types of cancer, for implantation without surgical incision, and use as highly effective wound dressings. Furthermore, conclusions and outlooks are discussed for the use of these promising and durable macroporous cryogels.

Biology ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 1038
Haodong Cui ◽  
Min Jiang ◽  
Wenhua Zhou ◽  
Ming Gao ◽  
Rui He ◽  

A carrier-free CRISPR/Cas9 ribonucleoprotein delivery strategy for genome editing mediated by a cold atmospheric plasma (CAP) is described. The CAP is promising in many biomedical applications due to efficient production of bioactive ionized species. The MCF-7 cancer cells after CAP exposure exhibit increased extracellular reactive oxygen and nitrogen species (RONS) and altered membrane potential and permeability. Hence, transmembrane transport of Ca2+ into the cells increases and accelerates ATP hydrolysis, resulting in enhanced ATP-dependent endocytosis. Afterwards, the increased Ca2+ and ATP contents promote the release of cargo into cytoplasm due to the enhanced endosomal escape. The increased membrane permeability also facilitates passive diffusion of foreign species across the membrane into the cytosol. After CAP exposure, the MCF-7 cells incubated with Cas9 ribonucleoprotein (Cas9-sgRNA complex, Cas9sg) with a size of about 15 nm show 88.9% uptake efficiency and 65.9% nuclear import efficiency via passive diffusion and ATP-dependent endocytosis pathways. The efficient transportation of active Cas9sg after the CAP treatment leads to 21.7% and 30.2% indel efficiencies in HEK293T and MCF-7 cells, respectively. This CAP-mediated transportation process provides a simple and robust alternative for the delivery of active CRISPR/Cas9 ribonucleoprotein. Additionally, the technique can be extended to other macro-biomolecules and nanomaterials to cater to different biomedical applications.

Metals ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 1626
Ildiko Peter

In the present research paper, two systems based on Ti-Nb-Zr-Ta and Ti-Nb-Zr–Fe, containing non-toxic elements, are considered and investigated. The first aim of the paper is to enlarge up-to-date developed β-type Ti alloys, analyzing three different compositions, Ti-10Nb-10Zr-5Ta, Ti-20Nb-20Zr-4Ta and Ti-29.3Nb-13.6Zr-1.9Fe, in order to assess their further employment in biomedical applications. To achieve this, structural, microstructural, compositional and mechanical investigations were performed as part of this study. Based on the results obtained, the alloy with the highest Nb content seems to be the most appropriate candidate for advanced biomedical applications and, in particular, for bone substitution.

Nimra Tariq ◽  
Muhammad Waseem Ashraf ◽  
Shahzadi Tayyaba

Shikai Zhang ◽  
Geoffrey I. N. Waterhouse ◽  
Fangzhou Xu ◽  
Ziyang He ◽  
Yuyi Du ◽  

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