Critical Update and Emerging Trends in Imatinib Treatment for Gastrointestinal Stromal Tumor

2007 ◽  
Vol 2 (1) ◽  
pp. 43-48 ◽  
Author(s):  
Ugo De Giorgi ◽  
Alberto Pupi ◽  
Gina Turrisi ◽  
Iolanda Montenora ◽  
Stefano Morini ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Stromal Tumor ◽  
Imatinib Treatment ◽  
Emerging Trends

Multiple Bowel Perforations Complicating Imatinib Treatment for Advanced Gastrointestinal Stromal Tumor

2008 ◽  
Vol 206 (2) ◽  
pp. 386-387 ◽  
Author(s):  
Massimo Chiarugi ◽  
Christian Galatioto ◽  
Piero V. Lippolis ◽  
Massimo Seccia
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Stromal Tumor ◽  
Imatinib Treatment

scholarly journals Successful Perioperative and Surgical Treatment of a Rare Case of Extra-Gastrointestinal Stromal Tumor Arising in the Prostate Gland

2019 ◽  
Vol 12 (1) ◽  
pp. 183-191 ◽  
Author(s):  
Patrick Schöffski ◽  
Raf Sciot ◽  
Maria Debiec-Rychter ◽  
Johan Van Ongeval ◽  
André D'Hoore ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Prostate Gland ◽  
Interstitial Cells ◽  
Stromal Tumor ◽  
Imatinib Treatment ◽  
Smooth Muscle Contractility ◽  
Double Mutation ◽  
Primary Gist ◽  
Common Precursor ◽  
Cells Of Cajal

We report a very uncommon case of a primary, non-metastatic gastrointestinal stromal tumor (GIST) arising in the prostate gland in a 60-year-old patient. The morphology and immunohistochemical profile of the disease resembled GIST of gastrointestinal origin, and the molecular driver of this malignancy was a double mutation in exons 11 and 13 of the KIT gene. The tumor was proliferating slowly, did respond to neoadjuvant therapy with the KIT-inhibiting agent imatinib and was cured by radical, retro-pubic prostatectomy followed by adjuvant imatinib treatment. We postulate that primary GIST tumors of the prostate can arise from prostatic interstitial cells, which are the pacemakers of smooth muscle contractility in the gland, and possibly share a common precursor with typical GIST and the interstitial cells of Cajal in the gastrointestinal tract.

scholarly journals Neoadjuvant imatinib treatment and laparoscopic anus-preserving surgery for a large gastrointestinal stromal tumor of the rectum

2016 ◽  
Vol 14 (1) ◽  
Author(s):  
Kennoki Kyo ◽  
Masaki Azuma ◽  
Kazuya Okamoto ◽  
Motohiro Nishiyama ◽  
Takahiro Shimamura ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Stromal Tumor ◽  
Imatinib Treatment

Surgical resection of gastrointestinal stromal tumor of esophagus following preoperative imatinib treatment: a case report

Esophagus ◽  
2010 ◽  
Vol 7 (1) ◽  
pp. 65-69 ◽  
Author(s):  
Hiroki Sato ◽  
Tatsuo Kanda ◽  
Seiichi Hirota ◽  
Takeo Bamba ◽  
Kaoru Sakamoto ◽  
...  
Keyword(s):  
Case Report ◽  
Gastrointestinal Stromal Tumor ◽  
Surgical Resection ◽  
Stromal Tumor ◽  
Imatinib Treatment

scholarly journals Gastrointestinal stromal tumor of unusual phenotype after imatinib treatment

Medicine ◽  
2017 ◽  
Vol 96 (49) ◽  
pp. e9031 ◽  
Author(s):  
Minsun Jung ◽  
Sung-Hye Park ◽  
Yoon Kyung Jeon ◽  
Jae-Kyung Won ◽  
Han-Kwang Yang ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Stromal Tumor ◽  
Imatinib Treatment ◽  
Unusual Phenotype
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