Septomics: Application of Systems Approaches to Sepsis - Potential for Personalized Management of Septic Patients

2010 ◽  
Vol 8 (2) ◽  
pp. 97-107
Author(s):  
Malak Kotb
Keyword(s):  
Systems Approaches ◽  
Personalized Management

Systems approaches to community problems

1971 ◽  
Author(s):  
Frank Baker ◽  
Nolan Penn ◽  
Dwight Harshbarger ◽  
Henry Wechsler ◽  
Denise Thum ◽  
...  
Keyword(s):  
Systems Approaches

Identification of Antineoplastic Targets with Systems Approaches, Using Resveratrol as an In-Depth Case Study

2017 ◽  
Vol 23 (32) ◽  
pp. 4773-4793 ◽  
Author(s):  
Nivedita Singh ◽  
Sherry Freiesleben ◽  
Olaf Wolkenhauer ◽  
Yogeshwer Shukla ◽  
Shailendra K. Gupta
Keyword(s):  
Drug Target ◽  
Complex Disease ◽  
Biological Targets ◽  
Systems Approaches ◽  
Anticancer Mechanism ◽  
Genetic And Environmental Factors ◽  
Key Steps ◽  
Network Approaches ◽  
Novel Drug

The identification and validation of novel drug–target combinations are key steps in the drug discovery processes. Cancer is a complex disease that involves several genetic and environmental factors. High-throughput omics technologies are now widely available, however the integration of multi-omics data to identify viable anticancer drug-target combinations, that allow for a better clinical outcome when considering the efficacy-toxicity spectrum, is challenging. This review article provides an overview of systems approaches which help to integrate a broad spectrum of technologies and data. We focus on network approaches and investigate anticancer mechanism and biological targets of resveratrol using reverse pharmacophore mapping as an in-depth case study. The results of this case study demonstrate the use of systems approaches for a better understanding of the behavior of small molecule inhibitors in receptor binding sites. The presented network analysis approach helps in formulating hypotheses and provides mechanistic insights of resveratrol in neoplastic transformations.

How to Control Asthma with Personalized Management: Where Do We Stand Now?

2018 ◽  
Vol 19 (14) ◽  
pp. 1188-1198 ◽  
Author(s):  
Meng Wang ◽  
Yuan Yao ◽  
Shanqun Jiang ◽  
Fang Tao ◽  
Rui Tang ◽  
...  
Keyword(s):  
Personalized Management ◽  
Control Asthma

scholarly journals Systems approaches to modelling pathways and networks

2011 ◽  
Vol 10 (5) ◽  
pp. 266-279 ◽  
Author(s):  
T. Pfau ◽  
N. Christian ◽  
O. Ebenhoh
Keyword(s):  
Systems Approaches

scholarly journals A research agenda on systems approaches to infrastructure

2020 ◽  
Vol 37 (4) ◽  
pp. 214-233 ◽  
Author(s):  
Jennifer Whyte ◽  
Ana Mijic ◽  
Rupert J. Myers ◽  
Panagiotis Angeloudis ◽  
Michel-Alexandre Cardin ◽  
...  
Keyword(s):  
Research Agenda ◽  
Systems Approaches

An affective learning-based system for diagnosis and personalized management of diabetes mellitus

2021 ◽  
Vol 117 ◽  
pp. 273-290
Author(s):  
Olatunji Mumini Omisore ◽  
Bolanle Adefowoke Ojokoh ◽  
Asegunoluwa Eunice Babalola ◽  
Tobore Igbe ◽  
Yetunde Folajimi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Affective Learning ◽  
Personalized Management

scholarly journals Systems approaches to preventing transplanted cell death in cardiac repair

2008 ◽  
Vol 45 (4) ◽  
pp. 567-581 ◽  
Author(s):  
Thomas E. Robey ◽  
Mark K. Saiget ◽  
Hans Reinecke ◽  
Charles E. Murry
Keyword(s):  
Cell Death ◽  
Cardiac Repair ◽  
Systems Approaches
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