Acute Posterior Multifocal Placoid Pigment Epitheliopathy (APMPPE) – a possible clinical picture of Ocular Borreliosis

Cilj: Prikazati slučaj pacijenta s akutnom posteriornom multifokalnom plakoidnom pigmentnom epiteliopatijom (APMPPE) u sklopu infekcije borelijom Lyme. Prikaz slučaja: Šesnaestogodišnjeg pacijenta uputio je pedijatar zbog naglog pada vidne oštrine na desnom oku. Vidna oštrina kod dolaska bila je 0,01 po Snellenu. Žalio se i na zatiljnu glavobolju unazad nekoliko dana i naveo ubod nepoznatog kukca s okolnim osipom na koži. Na oba oka na fundusu su se utvrdili znakovi korioretinitisa. Učinjena je optička koherentna tomografija (OCT, engl. optical coherence tomography), OCT-angiografija (OCT-A), vidno polje (VP), fluoresceinska angiografija (FA), angiografija indocijanin zelenilom (ICGA, engl. indocyanine green angiography), kompletna laboratorijska, serološka i imunološka obrada, rendgen srca i pluća, magnetska rezonancija (MR) mozga, pregled i konzultacija infektologa i neuropedijatra. Postavljena je dijagnoza APMPPE-a i uvedena peroralna terapija metilprednizolonom 0,5 mg/kg tjelesne težine i doksiciklinom 2 x 100 mg dnevno. Serodijagnostika je pokazala povišene vrijednosti IgM i IgG na Borreliu spp metodom imunoenzimske analize (ELISA, engl. Enzyme Linked Immuno Sorbent Assay), što je bilo potvrđeno western blot analizom. Terapija je dovela do brzog poboljšanja kliničke slike i vidne oštrine na 0,75. Zaključci: Želimo naglasiti da je u slučaju APMPPE-a potrebno napraviti kompletnu obradu kako bi se isključile konkomitantne infekcije, a potrebno je posumnjati i na okularnu boreliozu, osobito u slučaju ugriza krpelja ili nepoznatog kukca, čak i kad se pacijenti ne sjećaju ugriza. Ovakav pristup omogućava promptno liječenje APMPPE-a i borelioze kako bi se smanjile okularne ili/i sistemske komplikacije.

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Comparison of SD-Optical Coherence Tomography Angiography and Indocyanine Green Angiography in Type 1 and 2 Neovascular Age-related Macular Degeneration

Investigative Opthalmology & Visual Science ◽

10.1167/iovs.17-22902 ◽

2018 ◽

Vol 59 (6) ◽

pp. 2393 ◽

Cited By ~ 22

Author(s):

Reinhard Told ◽

Stefan Sacu ◽

Alexander Hecht ◽

Magdalena Baratsits ◽

Katharina Eibenberger ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Indocyanine Green ◽

Macular Degeneration ◽

Indocyanine Green Angiography ◽

Optical Coherence Tomography Angiography ◽

Age Related Macular Degeneration ◽

Optical Coherence ◽

Age Related

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Polypoidal Choroidal Vasculopathy in Congolese Patients

Journal of Ophthalmology ◽

10.1155/2020/4103871 ◽

2020 ◽

Vol 2020 ◽

pp. 1-10

Author(s):

Nelly N. Kabedi ◽

David L. Kayembe ◽

Gloria M. Elongo ◽

Jean-Claude Mwanza

Keyword(s):

Optical Coherence Tomography ◽

Indocyanine Green ◽

Polypoidal Choroidal Vasculopathy ◽

Indocyanine Green Angiography ◽

Clinical Presentation ◽

Case Series ◽

Systemic Hypertension ◽

Optical Coherence ◽

Blurred Vision ◽

Choroidal Vasculopathy

Purpose. Polypoidal choroidal vasculopathy (PCV) is a visually debilitating disease that mostly affects people of African and Asian heritage. Indocyanine green angiography (ICGA) is the recommended exploratory method for definitive diagnosis. The disease has been extensively described in Asians and Caucasians, but not in Africans. This study was conducted to document the clinical presentation and optical coherence tomography features of polypoidal choroidal vasculopathy (PCV) in Congolese patients. Methods. A prospective case series of patients with PCV was performed between January 2017 and June 2019. Routine ocular examination was performed including best corrected visual acuity measurement, slit-lamp examination, dilated direct fundoscopy, and spectral domain optical coherence tomography (OCT). The diagnosis was based on a combination of clinical and OCT signs. Results. Fourteen patients were diagnosed with PCV during this period. The average age was 64.7 ± 6.9 years. There were 8 females. Ten (71.4%) patients had systemic hypertension. Most patients (n = 9, 64.3%) had bilateral involvement. Blurred vision was the most common complaint (71.4%). The main clinical presentation was subretinal exudates, seen in 19 (82.6%) eyes of 11 (78.6%) patients and subretinal hemorrhage in 10 (43.5%) eyes. Macular localization was found in 16 eyes (69.5%) of 12 (85.7%) patients. Drusen were observed in 35.7% of the patients. On OCT imaging, thumb-like pigment epithelial detachment and subretinal exudation were the most frequent features, observed in 92.9% and 71.4% of the patients, respectively. Conclusions. PCV in Congolese patients showed features that are more similar to those observed in Caucasians. In this setting where indocyanine green angiography is not available, OCT facilitates the diagnosis of PCV.

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