scholarly journals Complex general surgical oncology: a case-based approach

Author(s):  
Daniel E Abbott ◽  
Jason B Fleming
Keyword(s):  
2013 ◽  
Author(s):  
Daniel E Abbott ◽  
Jason B Fleming
Keyword(s):  

2013 ◽  
Author(s):  
Daniel E Abbott ◽  
Jason B Fleming
Keyword(s):  

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. 1517-1517
Author(s):  
Stacy W. Gray ◽  
Angel M. Cronin ◽  
Lynette M. Sholl ◽  
Ethan Cerami ◽  
Jeffrey Gagan ◽  
...  

1517 Background: The increased availability of tumor genomic profiling is revolutionizing oncology. However, the promise of precision care will not be realized if providers misinterpret complex genomic data. Methods: We created web-based, interactive reports with enhanced data visualization elements and embedded decision support for > 300 gene panels. We conducted a randomized vignette-based survey study to determine whether exposure to the interactive reports, as compared to static reports, improves physicians’ genomic understanding and report-based satisfaction. Overall comprehension and satisfaction scores were calculated across three vignettes (possible range 0-18 and 1-4 respectively, higher score correspond to improved endpoints). Results: 105 physicians at a major cancer center participated (29% participation rate); 67% medical, 20% pediatric, 7% radiation and 7% surgical oncology; 37% female. Prior to viewing the case-based vignette reports, 34% of physicians reported that they found it difficult to make treatment recommendations based on the standard report in their routine practice. After viewing the case-based vignettes, physicians’ overall comprehension scores did not differ significantly by report type (mean score interactive 11.6 vs. static 10.5, difference = 1.1, 95% CI -0.3, 2.5, p = 0.13). However, physicians who viewed the interactive report were more likely to correctly assess sequencing quality (p < 0.001) and understand when reports needed to be interpreted with caution (e.g., if low tumor purity, p = 0.02). Overall satisfaction scores were significantly higher in the interactive group than the static group (mean score 2.5 vs. 2.1, difference = 0.4, 95% CI 0.2, 0.7, p = 0.001). Of the 92 physicians who endorsed the need for additional genomic support for providers, 66% reported that interactive genomic reports would be helpful. Conclusions: Interactive, genomic reports may improve physicians’ ability to accurately assess genomic data and increase physician satisfaction. To advance the field, further research in representative provider populations is warranted and efforts to integrate interactive genomic reports into electronic health records are needed.


2014 ◽  
Author(s):  
Daniel E Abbott ◽  
Jason B Fleming
Keyword(s):  

Author(s):  
M.A. Gregory ◽  
G.P. Hadley

The insertion of implanted venous access systems for children undergoing prolonged courses of chemotherapy has become a common procedure in pediatric surgical oncology. While not permanently implanted, the devices are expected to remain functional until cure of the primary disease is assured. Despite careful patient selection and standardised insertion and access techniques, some devices fail. The most commonly encountered problems are colonisation of the device with bacteria and catheter occlusion. Both of these difficulties relate to the development of a biofilm within the port and catheter. The morphology and evolution of biofilms in indwelling vascular catheters is the subject of ongoing investigation. To date, however, such investigations have been confined to the examination of fragments of biofilm scraped or sonicated from sections of catheter. This report describes a novel method for the extraction of intact biofilms from indwelling catheters.15 children with Wilm’s tumour and who had received venous implants were studied. Catheters were removed because of infection (n=6) or electively at the end of chemotherapy.


1998 ◽  
Vol 62 (3) ◽  
pp. 242-247
Author(s):  
PW Coleman
Keyword(s):  

1991 ◽  
Vol 5 (1) ◽  
pp. 125-145 ◽  
Author(s):  
Mike K. Chen ◽  
Wiley W. Souba ◽  
Edward M. Copeland

2016 ◽  
Vol 22 ◽  
pp. 48-49
Author(s):  
Amy Larkin ◽  
Colleen Healy ◽  
Anne Le

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