Molecular characterization of small and medium segments of Crimean-Congo hemorrhagic fever virus in Turkey

Aim: The objective was to investigate the genotypic relationship of S and M segments in Crimean-Congo hemorrhagic fever virus (CCHFV) by phylogenetic analysis in 25 patients from seven endemic cities in Turkey. Materials & methods: A total of 25 samples from patients with CCHF were included between 2012 and 2015. Phylogenetic tree analyses were inferred using MEGA version-6.0 and distances were calculated by Kimura’s 2-parameter. Results: Phylogenetic analysis showed that all isolated viruses (n = 25) were in the predicted clades such as clade V- Europe-1 regarding both S and M segments of the CCHFV. Conclusion: Further epidemiological, molecular and phylogenic studies should be performed in both reservoir animals/vectors and humans to determine the incidence of tick-borne infectious disease and to help to develop vaccines for prevention of the disease.

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Genetic Characterization of the M RNA Segment of Crimean Congo Hemorrhagic Fever Virus Strains, China

Emerging Infectious Diseases ◽

10.3201/eid0801.010087 ◽

2002 ◽

Vol 8 (1) ◽

pp. 50-53 ◽

Cited By ~ 51

Author(s):

Anna Papa

Keyword(s):

Genetic Characterization ◽

Hemorrhagic Fever ◽

Fever Virus ◽

Crimean Congo Hemorrhagic Fever ◽

Hemorrhagic Fever Virus ◽

Virus Strains

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First phylogenetic analysis of a Crimean-Congo hemorrhagic fever virus genome in naturally infected Rhipicephalus appendiculatus ticks (Acari: Ixodidae)

Archives of Virology ◽

10.1007/s00705-015-2379-1 ◽

2015 ◽

Vol 160 (5) ◽

pp. 1197-1209 ◽

Cited By ~ 6

Author(s):

Mohammad Reza Fakoorziba ◽

Ali Asghar Naddaf-Sani ◽

Mohammad Djaefar Moemenbellah-Fard ◽

Kourosh Azizi ◽

Sara Ahmadnia ◽

...

Keyword(s):

Phylogenetic Analysis ◽

Hemorrhagic Fever ◽

Virus Genome ◽

Rhipicephalus Appendiculatus ◽

Fever Virus ◽

Crimean Congo Hemorrhagic Fever ◽

Hemorrhagic Fever Virus

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BSL4 Facilities in Anti-Infectious Disease Measures

Journal of Disaster Research ◽

10.20965/jdr.2009.p0352 ◽

2009 ◽

Vol 4 (5) ◽

pp. 352-355 ◽

Cited By ~ 1

Author(s):

Ichiro Kurane ◽

Keyword(s):

Infectious Disease ◽

Hemorrhagic Fever ◽

Fever Virus ◽

Lassa Virus ◽

South American ◽

Environment Effect ◽

Crimean Congo Hemorrhagic Fever ◽

Hemorrhagic Fever Virus ◽

Multiple Factors ◽

Endemic Areas

Pathogens are divided into biosafety levels (BSL) 1 to 4 based on multiple factors such as virulence, transmissibility, environment effect, and treatment availability. BSL1 pathogens are the least virulent and BSL4 the most. BSL4 pathogens include ebolavirus, marburgvirus, Crimean-Congo hemorrhagic fever virus, lassa virus, variolla virus, and South American hemorrhagic fever viruses, as detailed in Table 1. Pathogens at each of the 4 BSLs must be handled in equivalently physically contained laboratories, graded P1-4. BSL4 pathogens do not exist in nature in Japan, which currently has no equivalent physical containment facilities, but the possibility exists that they may be brought into the country unintentionally by those infected in endemic areas or intentionally by bioterrorists.

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