scholarly journals In vivo tracking of segmental bone defect healing reveals that callus patterning is related to early mechanical stimuli

2012 ◽  
Vol 24 ◽  
pp. 358-371 ◽  
Author(s):  
M Mehta ◽  
◽  
S Checa ◽  
J Lienau ◽  
D Hutmacher ◽  
...  
Keyword(s):  
Bone Defect ◽  
Mechanical Stimuli ◽  
Segmental Bone Defect ◽  
Defect Healing ◽  
Bone Defect Healing ◽  
Segmental Bone

scholarly journals Hydrothermally converted marine coral scaffold promotes segmental bone defect healing in rats

2016 ◽  
Vol 7 ◽  
pp. 79-80
Author(s):  
Sien Lin ◽  
Wayne Yuk Wai Lee ◽  
Yuxin Sun ◽  
Liao Cui ◽  
David William Green ◽  
...  
Keyword(s):  
Bone Defect ◽  
Segmental Bone Defect ◽  
Defect Healing ◽  
Bone Defect Healing ◽  
Segmental Bone ◽  
Coral Scaffold

Large scale segmental bone defect healing through the combined delivery of VEGF and BMP‐2 from biofunctionalized cortical allografts

2018 ◽  
Vol 107 (4) ◽  
pp. 1002-1010 ◽  
Author(s):  
Farzana Sharmin ◽  
Michael O'Sullivan ◽  
Seth Malinowski ◽  
Jay R. Lieberman ◽  
Yusuf Khan
Keyword(s):  
Bone Defect ◽  
Large Scale ◽  
Segmental Bone Defect ◽  
Defect Healing ◽  
Bone Defect Healing ◽  
Segmental Bone

scholarly journals Augmentation of bone defect healing using a new biocomposite scaffold: An in vivo study in sheep

2010 ◽  
Vol 6 (9) ◽  
pp. 3755-3762 ◽  
Author(s):  
U. van der Pol ◽  
L. Mathieu ◽  
S. Zeiter ◽  
P.-E. Bourban ◽  
P.-Y. Zambelli ◽  
...  
Keyword(s):  
Bone Defect ◽  
In Vivo Study ◽  
Defect Healing ◽  
Bone Defect Healing

scholarly journals Time kinetics of bone defect healing in response to BMP-2 and GDF-5 characterised by in vivo biomechanics

2011 ◽  
Vol 21 ◽  
pp. 177-192 ◽  
Author(s):  
D Wulsten ◽  
◽  
V Glatt ◽  
A Ellinghaus ◽  
K Schmidt-Ble ◽  
...  
Keyword(s):  
Bone Defect ◽  
Defect Healing ◽  
Bone Defect Healing ◽  
Kinetics Of

scholarly journals Bone morphogenetic protein 2-induced cellular chemotaxis drives tissue patterning during critical-sized bone defect healing: an in silico study

2021 ◽  
Author(s):  
Edoardo Borgiani ◽  
Georg N. Duda ◽  
Bettina M. Willie ◽  
Sara Checa
Keyword(s):  
Bone Tissue ◽  
Bone Defect ◽  
Computer Model ◽  
In Silico ◽  
Bone Defects ◽  
Bone Morphogenetic Protein 2 ◽  
Defect Healing ◽  
Tissue Patterning ◽  
Bone Defect Healing

AbstractCritical-sized bone defects are critical healing conditions that, if left untreated, often lead to non-unions. To reduce the risk, critical-sized bone defects are often treated with recombinant human BMP-2. Although enhanced bone tissue formation is observed when BMP-2 is administered locally to the defect, spatial and temporal distribution of callus tissue often differs from that found during regular bone healing or in defects treated differently. How this altered tissue patterning due to BMP-2 treatment is linked to mechano-biological principles at the cellular scale remains largely unknown. In this study, the mechano-biological regulation of BMP-2-treated critical-sized bone defect healing was investigated using a multiphysics multiscale in silico approach. Finite element and agent-based modeling techniques were combined to simulate healing within a critical-sized bone defect (5 mm) in a rat femur. Computer model predictions were compared to in vivo microCT data outcome of bone tissue patterning at 2, 4, and 6 weeks postoperation. In vivo, BMP-2 treatment led to complete healing through periosteal bone bridging already after 2 weeks postoperation. Computer model simulations showed that the BMP-2 specific tissue patterning can be explained by the migration of mesenchymal stromal cells to regions with a specific concentration of BMP-2 (chemotaxis). This study shows how computational modeling can help us to further understand the mechanisms behind treatment effects on compromised healing conditions as well as to optimize future treatment strategies.

scholarly journals In vitro and in vivo assessment of nanostructured porous biphasic calcium phosphate ceramics for promoting osteogenesis in an osteoporotic environment

RSC Advances ◽  
2018 ◽  
Vol 8 (26) ◽  
pp. 14646-14653 ◽  
Author(s):  
Kun Zhang ◽  
Jieyu Zhang ◽  
Kelei Chen ◽  
Xuefeng Hu ◽  
Yunbing Wang ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Defect ◽  
Biphasic Calcium Phosphate ◽  
Calcium Phosphate Ceramics ◽  
Defect Healing ◽  
Bone Defect Healing ◽  
In Vivo Assessment ◽  
Porous Biphasic Calcium Phosphate

Nanostructured porous biphasic calcium phosphate ceramics are able to significantly promote bone defect healing in an osteoporotic environment.

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