AbstractThe Maeander river (modern Büyük Menderes Nehri) provides the longest natural route through the mountains of central western Anatolia to link the Aegean basin to inner Anatolia, and research suggests that permanent settlement within the river's catchment had begun at least tentatively by the Late Neolithic period. However, the limited amount of archaeological research in the region has restricted our understanding of the inhabitants' settlement histories and intra- and inter-regional cultural contacts during prehistory. This paper seeks to understand better the nature of settlement dynamics and cultural interactivity from the Neolithic period through to the Late Bronze Age in this region by reviewing the available literature within a broad geographic context encompassing western Anatolia and the Aegean, neighbours whose archaeological evaluations have largely been conducted in isolation from each other. The evidence suggests that these early communities interacted with each other and inter-regionally with fluctuating intensities during prehistory, with the interior remaining more traditionally Anatolian, while the lower, coastal area experienced increasing interaction with and influence from Aegean cultures over time. The lower valley also displays a relatively static number of prehistoric sites in contrast to the middle and upper regions, where more dynamic and largely parallel settlement histories are seen.