2197-P: SEL1L-HRD1 Endoplasmic Reticulum-Associated Degradation Is Required for Maintaining Glucagon Production in Pancreatic Alpha Cells

Diabetes ◽

10.2337/db19-2197-p ◽

2019 ◽

Vol 68 (Supplement 1) ◽

pp. 2197-P ◽

Author(s):

RACHEL B. REINERT ◽

NEHA SHRESTHA ◽

YEWEI JI ◽

LING QI

Keyword(s):

Endoplasmic Reticulum ◽

Alpha Cells ◽

Pancreatic Alpha Cells ◽

Endoplasmic Reticulum Associated Degradation

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Faculty Opinions recommendation of Sec61p is part of the endoplasmic reticulum-associated degradation machinery.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1283970.751071 ◽

2009 ◽

Author(s):

Davis Ng

Keyword(s):

Endoplasmic Reticulum ◽

Endoplasmic Reticulum Associated Degradation

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Faculty Opinions recommendation of Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.3025957.2738058 ◽

2010 ◽

Author(s):

Sarah Ferber ◽

Irit Meivar-Levy

Keyword(s):

Beta Cell ◽

Cell Loss ◽

Alpha Cells ◽

Pancreatic Alpha Cells

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Faculty Opinions recommendation of Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718248338.793496085 ◽

2014 ◽

Author(s):

Hidde Ploegh

Keyword(s):

Endoplasmic Reticulum ◽

Endoplasmic Reticulum Associated Degradation

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Faculty Opinions recommendation of The VCP/p97 and YOD1 Proteins Have Different Substrate-dependent Activities in Endoplasmic Reticulum-associated Degradation (ERAD).

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725850722.793510540 ◽

2015 ◽

Author(s):

Karin Romisch

Keyword(s):

Endoplasmic Reticulum ◽

Endoplasmic Reticulum Associated Degradation

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Faculty Opinions recommendation of GLP-1 suppresses glucagon secretion in human pancreatic alpha-cells by inhibition of P/Q-type Ca2+ channels.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.733957466.793572417 ◽

2020 ◽

Author(s):

Venkateswarlu Kanamarlapudi

Keyword(s):

Glucagon Secretion ◽

Alpha Cells ◽

Pancreatic Alpha Cells ◽

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Faculty Opinions recommendation of A technique for delineating the unfolding requirements for substrate entry into retrotranslocons during endoplasmic reticulum-associated degradation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.736962058.793568094 ◽

2019 ◽

Author(s):

Karin Romisch

Keyword(s):

Endoplasmic Reticulum ◽

Endoplasmic Reticulum Associated Degradation

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Conversion of proglucagon in pancreatic alpha cells: the major endproducts are glucagon and a single peptide, the major proglucagon fragment, that contains two glucagon-like sequences.

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.81.16.5007 ◽

1984 ◽

Vol 81 (16) ◽

pp. 5007-5011 ◽

Author(s):

C. Patzelt ◽

E. Schiltz

Keyword(s):

Alpha Cells ◽

Pancreatic Alpha Cells ◽

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New Insights into the Physiological Role of Endoplasmic Reticulum-Associated Degradation

Trends in Cell Biology ◽

10.1016/j.tcb.2016.12.002 ◽

2017 ◽

Vol 27 (6) ◽

pp. 430-440 ◽

Author(s):

Ling Qi ◽

Billy Tsai ◽

Peter Arvan

Keyword(s):

Endoplasmic Reticulum ◽

Physiological Role ◽

Endoplasmic Reticulum Associated Degradation

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NEONATAL HYPOGLYCÆMIA, HYPERINSULINISM, AND ABSENCE OF PANCREATIC ALPHA-CELLS

10.1016/s0140-6736(70)91946-x ◽

1970 ◽

Vol 295 (7660) ◽

pp. 1346 ◽

Author(s):

RonaldW. Gotlin ◽

H.K. Silver

Keyword(s):

Alpha Cells ◽

Neonatal Hypoglycaemia ◽

Pancreatic Alpha Cells

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Unraveling the function of Arabidopsis thaliana OS9 in the endoplasmic reticulum-associated degradation of glycoproteins

Plant Molecular Biology ◽

10.1007/s11103-012-9891-4 ◽

2012 ◽

Vol 79 (1-2) ◽

pp. 21-33 ◽

Author(s):

Silvia Hüttner ◽

Christiane Veit ◽

Jennifer Schoberer ◽

Josephine Grass ◽

Richard Strasser

Keyword(s):

Arabidopsis Thaliana ◽

Endoplasmic Reticulum ◽

Endoplasmic Reticulum Associated Degradation

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