Glucose and cyclic AMP as stimulators of somatostatin and insulin secretion from the isolated, perfused rat pancreas: a quantitative study

Diabetes ◽  
1981 ◽  
Vol 30 (1) ◽  
pp. 40-44 ◽  
Author(s):  
P. P. Gerber ◽  
E. R. Trimble ◽  
C. B. Wollheim ◽  
A. E. Renold ◽  
R. E. Miller
Keyword(s):  
Insulin Secretion ◽  
Cyclic Amp ◽  
Quantitative Study ◽  
Perfused Rat Pancreas ◽  
Rat Pancreas ◽  
Isolated Perfused Rat Pancreas

Glucose and Cyclic AMP as Stimulators of Somatostatin and Insulin Secretion From the Isolated, Perfused Rat Pancreas: A Quantitative Study

Diabetes ◽  
1981 ◽  
Vol 30 (1) ◽  
pp. 40-44 ◽  
Author(s):  
P. P. G. Gerber ◽  
E. R. Trimble ◽  
C. B. Wollheim ◽  
A. E. Renold ◽  
R. E. Miller
Keyword(s):  
Insulin Secretion ◽  
Cyclic Amp ◽  
Quantitative Study ◽  
Perfused Rat Pancreas ◽  
Rat Pancreas ◽  
Isolated Perfused Rat Pancreas

Effects of PHI on hormonal secretion from perfused rat pancreas

1983 ◽  
Vol 245 (4) ◽  
pp. E313-E317
Author(s):  
J. Szecowka ◽  
D. Tendler ◽  
S. Efendic
Keyword(s):  
Amino Acids ◽  
Insulin Secretion ◽  
Glucagon Release ◽  
The Novel ◽  
Perfused Rat Pancreas ◽  
Rat Pancreas ◽  
Isolated Perfused Rat Pancreas ◽  
Hormonal Secretion ◽  
D Cells

Effects of the novel gastrointestinal polypeptide PHI with N-terminal histidine, C-terminal isoleucine amide, and 27 amino acids have been studied in isolated perfused rat pancreas. PHI increased the release of insulin, glucagon, and somatostatin. The amounts of these hormones released were strictly dependent on the prevailing glucose concentrations. In the absence of glucose, PHI (1 nmol/liter) stimulated glucagon release. In the presence of 4.4 and 6.7 mmol/liter glucose, the same dose of this peptide stimulated insulin and somatostatin release. In the presence of 16.7 mmol/liter glucose, only insulin secretion was increased by PHI. When arginine was used as a secretagogue, PHI (10 nmol/liter) potentiated secretion of insulin, glucagon, and somatostatin. Thus, PHI may take part in the regulation of the function of the pancreatic A, B, and D cells.

Effect of Corticosterone on Carbamylcholine-, Leucine-, or Calcium-Induced Insulin Secretion by the Isolated Perfused Rat Pancreas*

Endocrinology ◽  
1984 ◽  
Vol 114 (4) ◽  
pp. 1086-1089 ◽  
Author(s):  
GEGHAM BARSEGHIAN ◽  
CYNTHIA TOMKINSON ◽  
DAVID L. HWANG ◽  
ARYE LEV-RAN
Keyword(s):  
Insulin Secretion ◽  
Perfused Rat Pancreas ◽  
Rat Pancreas ◽  
Isolated Perfused Rat Pancreas

Modulation by AUoxan of Glucagon and Insulin Secretion in the Isolated Perfused Rat Pancreas*

Endocrinology ◽  
1978 ◽  
Vol 102 (5) ◽  
pp. 1496-1500 ◽  
Author(s):  
YASUO GOTO ◽  
YUTAKA SEINO ◽  
TOMOHIKO TAMINATO ◽  
YOSHIMICHI INOUE ◽  
SEIZO KADOWAKI ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Perfused Rat Pancreas ◽  
Rat Pancreas ◽  
Isolated Perfused Rat Pancreas ◽  
Glucagon And Insulin

scholarly journals Inhibitory Effects of Synthetic Rat C-Peptide 1 on Insulin Secretion in the Isolated Perfused Rat Pancreas

1975 ◽  
Vol 117 (1) ◽  
pp. 79-83 ◽  
Author(s):  
TAKAYOSHI TOYOTA ◽  
KANJI ABE ◽  
MIKIHIKO KUDO ◽  
KENICHI KIMURA ◽  
YOSHIO GOTO
Keyword(s):  
Insulin Secretion ◽  
Inhibitory Effects ◽  
Perfused Rat Pancreas ◽  
C Peptide ◽  
Rat Pancreas ◽  
Isolated Perfused Rat Pancreas
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