Experimental study on prevention and treatment of postmenopausal osteoporosis by antioxidant stress of Mongolian medicine blue thorn regulating FoxO/Wnt/ β-catenin pathway

Author(s):  
Chongyang DONG ◽  
Yu FANG ◽  
Jianping SHI ◽  
Xiongyao WANG ◽  
Yan LIU ◽  
...  
Neurosurgery ◽  
1987 ◽  
Vol 21 (2) ◽  
pp. 215-217 ◽  
Author(s):  
José González-Darder ◽  
José Barberá ◽  
José Alamo ◽  
Fernando Garcia-Vázquez

2015 ◽  
Vol 4 (1) ◽  
pp. 47-49
Author(s):  
Kumar Senthil P. ◽  
◽  
Adhikari Prabha ◽  
Jeganathan . ◽  
Kumar Anup ◽  
...  

2010 ◽  
Vol 54 (2) ◽  
pp. 200-205 ◽  
Author(s):  
Jaime Kulak Júnior ◽  
Carolina Aguiar Moreira Kulak ◽  
Hugh S. Taylor

Selective estrogen receptor modulators (SERMs) have the ability to bind the estrogen receptor (ER) and are known to confer ER agonist or antagonist effects depending on the target tissue. A number of newer SERMs, including bazedoxifene, lasofoxifene and ospemifene, are currently under clinical development for the prevention and treatment of postmenopausal osteoporosis and for other indications. Although the possibility of developing a single agent that has all of the desired characteristics of an ideal SERM seems to be unlikely, progress in the clinical development of SERMs targeted to the ER suggests that these newer compounds may have attributes that represent an improvement relative to existing SERMs. A new approach to menopausal therapy is the tissue selective estrogen complex or the pairing of a selective estrogen receptor modulator with estrogens. Further investigation will help to clarify relative benefits/risks of novel SERMs in development within specific indications.


2003 ◽  
Vol 37 (5) ◽  
pp. 711-724 ◽  
Author(s):  
Samantha F Eichner ◽  
Kimberly B Lloyd ◽  
Erin M Timpe

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