Improving Multi-Speaker Tacotron with Speaker Gating Mechanisms

2020 ◽  
Author(s):  
Wei Zhao ◽  
Li Xu ◽  
Ting He
Keyword(s):  
Gating Mechanisms

Ion-channel gating mechanisms: model identification and parameter estimation from single channel recordings

1989 ◽  
Vol 236 (1285) ◽  
pp. 385-416 ◽  
Keyword(s):  
Parameter Estimation ◽  
Single Channel ◽  
Channel Gating ◽  
Model Identification ◽  
Simulated Data ◽  
Process Models ◽  
Gating Mechanisms ◽  
Gating Mechanism ◽  
Incorrect Model ◽  
Schwarz Criterion

Patch-clamp data may be analysed in terms of Markov process models of channel gating mechanisms. We present a maximum likelihood algorithm for estimation of gating parameters from records where only a single channel is present. Computer simulated data for three different models of agonist receptor gated channels are used to demonstrate the performance of the procedure. Full details of the implementation of the algorithm are given for an example gating mechanism. The effects of omission of brief openings and closings from the single-channel data on parameter estimation are explored. A strategy for discriminating between alternative possible gating models, based upon use of the Schwarz criterion, is described. Omission of brief events is shown not to lead to incorrect model identification, except in extreme circumstances. Finally, the algorithm is extended to include channel gating models exhibiting multiple conductance levels.

scholarly journals Gating mechanisms of acid-sensing ion channels

Nature ◽  
2018 ◽  
Vol 555 (7696) ◽  
pp. 397-401 ◽  
Author(s):  
Nate Yoder ◽  
Craig Yoshioka ◽  
Eric Gouaux
Keyword(s):  
Ion Channels ◽  
Gating Mechanisms ◽  
Acid Sensing Ion Channels

scholarly journals Structural insights into the gating mechanisms of TRPV channels

Cell Calcium ◽  
2020 ◽  
Vol 87 ◽  
pp. 102168 ◽  
Author(s):  
Ruth A. Pumroy ◽  
Edwin C. Fluck ◽  
Tofayel Ahmed ◽  
Vera Y. Moiseenkova-Bell
Keyword(s):  
Gating Mechanisms ◽  
Trpv Channels ◽  
Structural Insights

Voltage-Gating Mechanisms of Connexin Channels

Connexins ◽  
2009 ◽  
pp. 103-128 ◽  
Author(s):  
Thaddeus Bargiello ◽  
Peter Brink
Keyword(s):  
Voltage Gating ◽  
Gating Mechanisms
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