Characterization of protection against systemic infection and disease from experimental bovine viral diarrhea virus type 2 infection by use of a modified-live noncytopathic type 1 vaccine in calves

2007 ◽  
Vol 68 (7) ◽  
pp. 788-796 ◽  
Author(s):  
Clayton L. Kelling ◽  
Breck D. Hunsaker ◽  
David J. Steffen ◽  
Christina L. Topliff ◽  
Kent M. Eskridge
2020 ◽  
Vol 72 (3) ◽  
pp. 655-663
Author(s):  
C. Chen ◽  
Y. Liu ◽  
H. Huang ◽  
Q. Meng ◽  
M. Xia ◽  
...  

ABSTRACT This study was designed to evaluate the extent of the protection for bovine viral diarrhea virus type 2 (BVDV-2) infection, afforded by vaccination with a combo inactivated vaccine, which contains bovine viral diarrhea virus type 1 (BVDV-1) and infectious bovine rhinotracheitis virus (IBRV). Five 3-4-month-old calves were intramuscularly vaccinated with a single dose of the combo vaccine and boosted with same dose three weeks after the first vaccination, with five mock immunized calves serving as a control group. Twenty-one days after the second vaccination, all calves were challenged with BVDV-2 SX08 strain by spray into nostril. The unvaccinated animals developed typical clinical signs of high rectal temperature, diarrhoea with erosions and a dramatic drop in leukocyte counts. These signs occured markedly less in all vaccinated animals, the rectal temperature, leukopenia and virarmia of which, were significantly less than the mock immunized calves. It can be concluded that vaccination with the combo inactivated vaccine affords cross-protection against clinical effects of a challenge-infection with BVDV-2 SX08 strain, although it was part protection.


2002 ◽  
Vol 87 (1) ◽  
pp. 51-60 ◽  
Author(s):  
Eduardo F Flores ◽  
Julia F Ridpath ◽  
Rudi Weiblen ◽  
Fernanda S.F Vogel ◽  
Laura H.V.G Gil

2003 ◽  
Vol 65 (2) ◽  
pp. 263-266 ◽  
Author(s):  
Tomoaki SHIMAZAKI ◽  
Shigeyuki NAKAMURA ◽  
Kunihiko TAGUCHI ◽  
Yoshimitsu INOUE

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