scholarly journals Evaluation of retinal nerve fiber layer thickness measured by (OCT) optical coherence tomography in patients with multiple sclerosis (MS): تقييم سماكة طبقة ألياف العصب البصري باستخدام التصوير البصري المقطعي التوافقي لدى مرضى التصلب اللويحي

2021 ◽  
Vol 5 (3) ◽  
pp. 18-1
Author(s):  
Mustafa Nassan Hasoun, Yusuf Suleiman, Hala Saeed Mustafa Nassan Hasoun, Yusuf Suleiman, Hala Saeed
Keyword(s):  
Optical Coherence Tomography ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Nerve Fiber Layer Thickness ◽  
Rnfl Thickness ◽  
Disability Status ◽  
Retinal Nerve Fiber

Objective: The aim of this study is to evaluate the retinal nerve fiber layer (RNFL) thickness by optical coherence tomography (OCT) in Syrian patients with MS and diseases- free controls and to assess this thickness in MS-ON and MS-NON, and assess the relationship between RNFL thickness Expanded Disability Status Scale (EDSS) score. Although there are many similar studies to evaluate role of OCT at MS patients in different countries and many races,but this study is the first one of using OCT at MS patients in our country. Methods: This study (cross sectional ,case- control) was carried out at Tishreen University Hospital in Latakia. A total of 112 eyes from 56 individuals with an age range from 22 to 43 years were studied. twenty -six patients with definite MS, Diagnosis of MS was based on the MacDonald criteria.The disease-free controls were matched for age and gender (n=30; 60eyes). Retinal nerve fiber layer thickness was measured using optical coherence tomography (Spectralis OCT - Heidelberg Engineering), and gathering information about past ON history since more than 6 months and EDSS. Results: There were statistically Significant differences (p=0.0001) between both groups (case- control) were observed in OCT parameters (average, and all sectors especially temporal and superior sector) with lower RNFL thickness in the MS group (MS-ON,MS-NON).There were statistically significant differences (p=0.0001) between MS-ON (n = 20 eyes) and MS-NON (n = 32eyes) for all RNFL parameters measured by OCT, with lower RNFL thickness in (MS-ON).There were statistically significant inverse correlations was observed between average RNFL thickness and neurologic impairment (Expanded Disability Status Scale) (r=- 0.6، P=0.0001) and all sectors especially in temporal and superior quadrants (r=-7 , P=0.0001). Conclusions: OCT seems to be a reproducible test to detect axonal loss of ganglion cells in MS (RNFL). Further and larger longitudinal prospective studies would be valuable to assess the evolution over time of the RNFL measurements in Syrian MS patients.

Comparative Analysis of Retinal Nerve Fiber Layer Thickness between Normal and Mild to Moderately Myopic Eyes

2021 ◽  
Vol 37 (4) ◽  
Author(s):  
Gul Nasreen ◽  
Shaheer Suhail Sarwar ◽  
Irfana Bibi ◽  
Muhammad Arslan Ashraf
Keyword(s):  
Optical Coherence Tomography ◽  
Nerve Fiber ◽  
Layer Thickness ◽  
Retinal Nerve Fiber Layer ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Nerve Fiber Layer Thickness ◽  
Rnfl Thickness ◽  
The Mean ◽  
Retinal Nerve Fiber

Purpose:  To determine the difference between mean retinal nerve fiber layer (RNFL) thickness in myopic eyes (up to -6.00D) and normal eyes. Study Design:  Descriptive observational study. Place and Duration of the Study:  Eye department of Mayo hospital Lahore, from February 2019 to April 2019. Methods:  We compared the mean RNFL between 58 myopic eyes (up to -6.00 D) and age matched 60 normal eyes. The age of the participants was between 12 to 42 years. Complete ocular examination was done and RNFL thickness was measured by using Optical coherence tomography (NIDEX RS-33.0, software-ex 1.5.2).Data was analyzed by independent sample t-test by using SPSS; with P < .05 as significant. Results:  The mean difference among these groups was 5.852 µm with (SE: 1.929). Mean RNFL thickness in myopic group was (95.93 ± 10.158µm) with (SE: 1.334). The result for mean RNFL thickness in myopic eyes was distributed normally as P < .03. Mean RNFL in normal group was (101.78 ± 10.774 µm) with (SE: 1.391), and the result of mean RNFL thickness measured in normal eyes was not distributed normally as P < .20. The results showed that there is a statistically significant difference between mean RNFL thickness measured in normal versus myopic eyes as (P < .003). Conclusion:  There is a significance difference between mean RNFL thickness between myopic eyes and normal eyes as measured by OCT. Careful interpretation of RNFL data in myopic eyes is recommended to avoid misdiagnosis with glaucoma. Key Words:  Retinal Nerve Fiber Layer thickness, Myopia, Optical Coherence Tomography.

Tracking retinal nerve fiber layer loss after optic neuritis: a prospective study using optical coherence tomography

2008 ◽  
Vol 14 (7) ◽  
pp. 893-905 ◽  
Author(s):  
F Costello ◽  
W Hodge ◽  
YI Pan ◽  
E Eggenberger ◽  
S Coupland ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Neuritis ◽  
Nerve Fiber ◽  
Layer Thickness ◽  
Retinal Nerve Fiber Layer ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Nerve Fiber Layer Thickness ◽  
Retinal Nerve Fiber

Introduction Optic neuritis causes retinal nerve fiber layer damage, which can be quantified with optical coherence tomography. Optical coherence tomography may be used to track nerve fiber layer changes and to establish a time-dependent relationship between retinal nerve fiber layer thickness and visual function after optic neuritis. Methods This prospective case series included 78 patients with optic neuritis, who underwent optical coherence tomography and visual testing over a mean period of 28 months. The main outcome measures included comparing inter-eye differences in retinal nerve fiber layer thickness between clinically affected and non-affected eyes over time; establishing when RNFL thinning stabilized after optic neuritis; and correlating retinal nerve fiber layer thickness and visual function. Results The earliest significant inter-eye differences manifested 2-months after optic neuritis, in the temporal retinal nerve fiber layer. Inter-eye comparisons revealed significant retinal nerve fiber layer thinning in clinically affected eyes, which persisted for greater than 24 months. Retinal nerve fiber thinning manifested within 6 months and then stabilized from 7 to 12 months after optic neuritis. Regression analyses demonstrated a threshold of nerve fiber layer thickness (75μm), which predicted visual recovery after optic neuritis. Conclusions Retinal nerve fiber layer changes may be tracked and correlated with visual function within 12 months of an optic neuritis event.

Evaluation of the Effect of Aging on Retinal Nerve Fiber Layer Thickness Measured by Optical Coherence Tomography

2003 ◽  
Vol 217 (4) ◽  
pp. 273-278 ◽  
Author(s):  
Akiyasu Kanamori ◽  
Michael F.T. Escano ◽  
Ayako Eno ◽  
Makoto Nakamura ◽  
Hidetaka Maeda ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Nerve Fiber ◽  
Layer Thickness ◽  
Retinal Nerve Fiber Layer ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Nerve Fiber Layer Thickness ◽  
Retinal Nerve Fiber

Retinal Nerve Fiber Layer Imaging with Spectral-domain Optical Coherence Tomography (OCT)—A Review of the Cirrus HD-OCT

2011 ◽  
Vol 04 (01) ◽  
pp. 12 ◽  
Author(s):  
Elaine To ◽  
Dennis Lam ◽  
Christopher Kai-shun Leung ◽  
◽  
◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Spectral Domain Oct ◽  
Rnfl Thickness ◽  
Retinal Nerve Fiber

High-speed, high-resolution imaging of the retinal nerve fiber layer (RNFL) with spectral-domain optical coherence tomography (OCT) has become an essential tool for evaluation of glaucoma. The Cirrus HD-OCT (Carl Zeiss Meditec, Inc. Dublin, CA) is a spectral-domain OCT that provides visualization of the distribution pattern and measurement of RNFL abnormalities in a 6x6mm2optic disc region. Analysis of the RNFL thickness deviation map—a color-coded map displaying areas of RNFL abnormalities—detects glaucoma with high sensitivity and specificity. Trend analysis of average and sectorial RNFL thicknesses, and event analysis of the RNFL thickness maps and the RNFL thickness profiles can be used to detect and follow diffuse and focal RNFL progression. RNFL measurement with spectral-domain OCT could provide important information for use in formulating treatment plans and evaluating disease prognosis in the management of glaucoma.

Sign in / Sign up

Export Citation Format

Share Document