Direct Access to Highly Enantioenriched α-Branched Acrylonitriles through a one-pot Sequential Asymmetric Michael addition/retro-Dieckmann/retro-Michael Fragmentation Cascade
Keyword(s):
One Pot
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A highly enantioselective synthesis of a-branched acrylonitriles is reported featuring a one-pot sequential asymmetric Michael addition/retro-Dieckmann/retro-Michael fragmentation cascade. The method, which relies on a solid, bench-stable and commercially available acrylonitrile surrogate, is practical, scalable, highly versatile, and provides a direct access to a wide range of enantioenriched nitrile-containing building blocks. Most importantly, the method offers a new tool to incorporate an acrylonitrile moiety in an asymmetric fashion.<br>