Direct Access to Mono-Protected Homoallylic 1,2-Diols via Dual Chromium/ Photoredox Catalysis
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<p>A dual catalytic strategy enables the efficient synthesis of mono-protected homoallylic 1,2-diols by coupling abundant aldehydes with simple (silyl) enol ethers, thus providing direct access to this important motif without the (super)stoichiometric use of prefunctionalized metal-allyl species. A variety of silyl- and alkyl-based protecting groups is shown and functional group tolerance, chemoselectivity and scalability are highlighted. </p>
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1997 ◽
pp. 1987-1996
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2006 ◽
Vol 12
(4)
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pp. 1221-1236
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1976 ◽
Vol 49
(8)
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pp. 2284-2291
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