carbonyl compounds
Recently Published Documents





Chemosensors ◽  
2022 ◽  
Vol 10 (1) ◽  
pp. 31
Marta Kowalska ◽  
Dominik Popiel ◽  
Martyna Walter ◽  
Remigiusz Bąchor ◽  
Monika Biernat ◽  

Analysis of peptide biomarkers of pathological states of the organism is often a serious challenge, due to a very complex composition of the cell and insufficient sensitivity of the current analytical methods (including mass spectrometry). One of the possible ways to overcome this problem is sample enrichment by capturing the selected components using a specific solid support. Another option is increasing the detectability of the desired compound by its selective tagging. Appropriately modified and immobilized peptides can be used for these purposes. In addition, they find application in studying the specificity and activity of proteolytic enzymes. Immobilized heterocyclic peptide conjugates may serve as metal ligands, to form complexes used as catalysts or analytical markers. In this review, we describe various applications of immobilized peptides, including selective capturing of cysteine-containing peptides, tagging of the carbonyl compounds to increase the sensitivity of their detection, enrichment of biological samples in deoxyfructosylated peptides, and fishing out of tyrosine–containing peptides by the formation of azo bond. Moreover, the use of the one-bead-one-compound peptide library for the analysis of substrate specificity and activity of caspases is described. Furthermore, the evolution of immobilization from the solid support used in peptide synthesis to nanocarriers is presented. Taken together, the examples presented here demonstrate immobilized peptides as a multifunctional tool, which can be successfully used to solve multiple analytical problems.

Tarun K. Panda ◽  
Ravi Kumar ◽  
Parveen Rawal ◽  
Indrani Banerjee ◽  
Hari Pada Nayek ◽  

Molecules ◽  
2022 ◽  
Vol 27 (2) ◽  
pp. 460
Tímea R. Kégl ◽  
László T. Mika ◽  
Tamás Kégl

Palladium-catalyzed carbonylation reactions, in the presence of nucleophiles, serve as very potent tools for the conversion of aryl and alkenyl halides or halide equivalents to carboxylic acid derivatives or to other carbonyl compounds. There are a vast number of applications for the synthesis of simple building blocks as well as for the functionalization of biologically important skeletons. This review covers the history of carbonylative coupling reactions in Hungary between the years 1994 and 2021.

Tarun Kanti Panda ◽  
Shreya Mahato ◽  
Parveen Rawal ◽  
Ajitaro Devadkar ◽  
Mayank Joshi ◽  

We report the synthesis, characterisation, and catalytic application of a palladium (II) complex [(4-{1,2-C6H4(N=CH-C6H4O)2}Pd] (1) supported by a dianionic salen ligand [1,2-C6H4(N=CH-C6H4O)2]2- (L) as a molecular pre-catalyst for the hydroboration...

Leilei Wang ◽  
Leiyang Lv ◽  
Zhiping Li

In previous literature, incorporation of functional groups at the α-position of unactivated carbonyl compounds was mainly restricted to one kind of corresponding precursors. Herein, we report the concomitant functionalization of...

2022 ◽  
Man-Man Xue ◽  
Jiarui Chang ◽  
Jie Zhang ◽  
Xuenian Chen

Diphosphino-boryl-based PBP pincer platinum thiolate complexes, [Pt(SR){B(NCH2PtBu2)2-1,2-C6H4}] (R = H, 1a; Ph, 1b), and benzene-based bisphosphinite POCOP pincer platinum thiolate complexes, [Pt(SR)(tBu2PO)2-1,3-C6H3] (R = H, 2a; Ph, 2b), were prepared...

2022 ◽  
pp. 134545
Dan Xu ◽  
Jianfeng Li ◽  
Boyang Li ◽  
Huacheng Zhao ◽  
Hanghang Zhu ◽  

Sign in / Sign up

Export Citation Format

Share Document