Species-dependent metabolism of a novel selective α7 neuronal acetylcholine receptor agonist ABT-107

Xenobiotica ◽

10.3109/00498254.2012.760763 ◽

2013 ◽

Vol 43 (9) ◽

pp. 803-816 ◽

Author(s):

Hong Liu ◽

Xiaoqing Deng ◽

Jinrong Liu ◽

Ning Liu ◽

Patricia Stuart ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Receptor Agonist ◽

Neuronal Acetylcholine Receptor

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Metabolism and Disposition of a Novel Selective α7 Neuronal Acetylcholine Receptor Agonist ABT-126 in Humans: Characterization of the Major Roles for Flavin-Containing Monooxygenases and UDP-Glucuronosyl Transferase 1A4 and 2B10 in Catalysis

Drug Metabolism and Disposition ◽

10.1124/dmd.117.077511 ◽

2018 ◽

Vol 46 (4) ◽

pp. 429-439 ◽

Author(s):

Hong Liu ◽

David M. Stresser ◽

Melissa J. Michmerhuizen ◽

Xiaofeng Li ◽

Ahmed A. Othman ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Receptor Agonist ◽

Neuronal Acetylcholine Receptor ◽

Glucuronosyl Transferase

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Metabolism and disposition of ABT-894, a novelα4β2 neuronal acetylcholine receptor agonist, in mice and monkeys

Xenobiotica ◽

10.3109/00498254.2013.855836 ◽

2014 ◽

Vol 44 (6) ◽

pp. 531-540 ◽

Author(s):

Hong Liu ◽

Wentao Fu ◽

Jill Wetter ◽

Hongyu Xu ◽

Zhiwen Guan ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Receptor Agonist ◽

Neuronal Acetylcholine Receptor

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Correction to “Metabolism and Disposition of a Novel Selective α7 Neuronal Acetylcholine Receptor Agonist ABT-126 in Humans: Characterization of the Major Roles for Flavin-Containing Monooxygenases and UDP-Glucuronosyl Transferase 1A4 and 2B10 in Catalysis”

Drug Metabolism and Disposition ◽

10.1124/dmd.117.077511err ◽

2018 ◽

Vol 46 (9) ◽

pp. 1382-1382

Keyword(s):

Acetylcholine Receptor ◽

Receptor Agonist ◽

Neuronal Acetylcholine Receptor ◽

Glucuronosyl Transferase

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Synergism of fipronil, lindane and dieldrin by the muscarinic acetylcholine receptor agonist pilocarpine in Drosophila melanogaster

10.1021/scimeetings.0c06751 ◽

2020 ◽

Author(s):

Na Xie ◽

Aaron Gross

Keyword(s):

Drosophila Melanogaster ◽

Acetylcholine Receptor ◽

Receptor Agonist ◽

Muscarinic Acetylcholine Receptor ◽

Muscarinic Acetylcholine

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Faculty Opinions recommendation of Structure of the first transmembrane domain of the neuronal acetylcholine receptor beta2 subunit.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1084909.537850 ◽

2007 ◽

Author(s):

Robert Ruff

Keyword(s):

Acetylcholine Receptor ◽

Transmembrane Domain ◽

Neuronal Acetylcholine Receptor

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The pharmacological assessment of RS 86 (2-ethyl-8-methyl-2,8-diazaspiro-[4,5]-decan-1,3-dion hydrobromide). A potent, specific muscarinic acetylcholine receptor agonist

European Journal of Pharmacology ◽

10.1016/0014-2999(86)90082-8 ◽

1986 ◽

Vol 125 (1) ◽

pp. 45-62 ◽

Author(s):

José M. Palacios ◽

Georg Bolliger ◽

Annemarie Closse ◽

Albert Enz ◽

Gernot Gmelin ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Receptor Agonist ◽

Muscarinic Acetylcholine Receptor ◽

Muscarinic Acetylcholine

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Epibatidine, a nicotinic acetylcholine receptor agonist, inhibits the capsaicin response in dorsal root ganglion neurons

Brain Research ◽

10.1016/s0006-8993(01)03028-1 ◽

2001 ◽

Vol 919 (1) ◽

pp. 166-168 ◽

Author(s):

Xu-Feng Zhang ◽

David G. McKenna ◽

Clark A. Briggs

Keyword(s):

Dorsal Root Ganglion ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Dorsal Root ◽

Receptor Agonist ◽

Dorsal Root Ganglion Neurons ◽

Nicotinic Acetylcholine ◽

Ganglion Neurons

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Protein-ligand interactions. 6 nicotinic acetylcholine receptor agonist activity of isoquinoline alkaloids

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(96)00429-5 ◽

1996 ◽

Vol 6 (23) ◽

pp. 2801-2806 ◽

Author(s):

C.G. Whiteley ◽

S. Daya

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Receptor Agonist ◽

Agonist Activity ◽

Isoquinoline Alkaloids ◽

Nicotinic Acetylcholine ◽

Protein Ligand Interactions ◽

Ligand Interactions

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In Vitro Pharmacological Characterization of a Novel Selective α7 Neuronal Nicotinic Acetylcholine Receptor Agonist ABT-107

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.110.167072 ◽

2010 ◽

Vol 334 (3) ◽

pp. 863-874 ◽

Author(s):

John Malysz ◽

David J. Anderson ◽

Jens H. Grønlien ◽

Jianguo Ji ◽

William H. Bunnelle ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Receptor Agonist ◽

Neuronal Nicotinic Acetylcholine Receptor ◽

Pharmacological Characterization ◽

Nicotinic Acetylcholine

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P4-310: Preclinical characterization of a selective alpha-7 neuronal nicotinic acetylcholine receptor agonist ABT-126: A novel therapeutic agent for the treatment of cognitive impairment in Alzheimer's disease and schizophrenia

Alzheimer s & Dementia ◽

10.1016/j.jalz.2013.05.1755 ◽

2013 ◽

Vol 9 ◽

pp. P817-P818 ◽

Author(s):

Robert Bitner ◽

David Anderson ◽

Karla Drescher ◽

Kathy Kohlhaas ◽

Halvard Gronlien ◽

...

Keyword(s):

Cognitive Impairment ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Receptor Agonist ◽

Therapeutic Agent ◽

Neuronal Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Alpha 7 ◽

Novel Therapeutic

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