A new approach to encapsulating nonsteroidal anti-inflammatory drugs. I. Bioavailability and gastric ulcerogenic activity

1987 ◽  
Vol 4 (2) ◽  
pp. 133-140 ◽  
Author(s):  
M. M. Meshali ◽  
E. Z. El-Dien ◽  
S. A. Omar ◽  
L. A. Luzzi
Keyword(s):  
New Approach ◽  
Ulcerogenic Activity ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals N,N-Dimethylformamide Prevents LPS-Induced Preterm Birth in a Murine Model by Suppressing the Inflammatory Response

2021 ◽  
Author(s):  
Zeng-Hui Wei ◽  
Oluwabukola Salami ◽  
Jagadish Koya ◽  
Swapna Munnangi ◽  
Ryan Pekson ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Murine Model ◽  
Raw 264.7 Cells ◽  
New Approach ◽  
Affect Cell Viability ◽  
Pregnant Mice ◽  
Inflammatory Drugs ◽  
The Common ◽  
Anti Inflammatory

Abstract Preterm birth accounts for the majority of perinatal mortality worldwide and there remains no FDA-approved drug to prevent it. Recently, we discovered that the common drug excipient, N,N-dimethylacetamide (DMA), prevents inflammation–induced preterm birth in mice by inhibiting NF-κB. Since we reported this finding it has come to light that a group of widely used, structurally related aprotic solvents, including DMA, N-methyl-2-pyrrolidone (NMP) and dimethylformamide (DMF), have anti-inflammatory efficacy. We show here that DMF suppresses LPS-induced TNFα secretion from RAW 264.7 cells and IL-6 and IL-8 secretion from HTR-8 cells at concentrations that do not significantly affect cell viability. In vivo, DMF decreases LPS-induced inflammatory cell infiltration and expression of TNFα and IL-6 in the placental labyrinth, all to near baseline levels. Finally, DMF decreases the rate of preterm birth in LPS-induced pregnant mice (P<.0001) and the rate at which pups are spontaneously aborted (P<.0001). In summary, DMF, a widely used solvent structurally related to DMA and NMP, prevents LPS-induced preterm birth in a murine model without overt toxic or teratogenic effects. Re-purposing the DMA/DMF/NMP family of small molecules as anti-inflammatory drugs is a promising new approach to preventing inflammation–induced preterm birth and potentially other inflammatory disorders as well.

A new approach to anti-inflammatory drugs

1979 ◽  
Vol 28 (12) ◽  
pp. 1959-1961 ◽  
Author(s):  
Gerald A. Higgs ◽  
Roderick J. Flower ◽  
John R. Vane
Keyword(s):  
New Approach ◽  
Inflammatory Drugs ◽  
Anti Inflammatory
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