A new approach to encapsulating nonsteroidal antiinflammatory drugs. IV. Effect of cellulose derivatives with different functional groups on the bioavailability and gastric ulcerogenic activity of acidic as well as basic nonsteroidal anti-inflammatory drugs

Context : Drug therapy is the most commonly used method in disease treatment in general practice. The pattern of drug prescription are often inappropriate and need for registration of these patterns is essentian in an effort to improve prescribing standard. Nonsteroidal antiinflammatory drugs (NSAIDs) are a drug class that groups together drugs that provide analgesic (pain-killing) and antipyretic (fever-reliefing) effects, and, in higher doses, anti-inflammatory effects. Non steroidal anti inflammatory drugs are the most common drugs prescribed in the world over specially in the orthopedic department. The study of prescribing pattern of NSAIDs in the orthopedic department was conducted to monitor, evaluate and if necessary suggest modification in the prescribing behavior of the medical practitioner to make it rational and cost effective.Material and Methods: The present study was performed on 300 (Three hundred) prescriptions from both admitted and outpatients (OPD) of the orthopedic department of Dhaka Medical College Hospital, Dhaka. The check list type of data was collected with prior permission from the concern department and the authority. The study was cross sectional analytical type and was conducted in the department of Pharmacology, Dhaka Medical College, Dhaka, from July 2010 to June 2011.Result : In case of OPD patients most common NSAIDs prescribed to the patients were aceclofenac (44.7%); followed by diclofenac (23.3%). Other NSAIDs were naproxen, ketorolac and ibuprofen 8%, 15.3% and 5.4% respectively. In case of admitted patients most common NSAIDs prescribed to the patients were ketorolac (54.7%) followed by diclofenac (24.0%).Conclusion: Non steroidal anti inflammatory drugs were the main prescription drug for both indoor and outdoor patients in the orthopedic department. Aceclofenac in outdoor and ketorolac in indoor were the most common NSAIDs drug used.J Dhaka Medical College, Vol. 25, No.1, April, 2016, Page 58-60

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EFFECTIVENESS AND SAFETY ASSESSMENT OF FIXED DOSE COMBINATION OF NON-STEROIDAL ANTIINFLAMMATORY DRUGS PRESCRIBED FOR ORTHOPEDIC PATIENTS

International Journal of Pharmacy and Pharmaceutical Sciences ◽

10.22159/ijpps.2020v12i2.35666 ◽

2019 ◽

pp. 70-73

Author(s):

NILAY SOLANKI ◽

ALPA GOR ◽

BIRAJ PARMAR

Keyword(s):

Adverse Effects ◽

Tertiary Care ◽

The Other ◽

Fixed Dose Combination ◽

Fixed Dose ◽

Antiinflammatory Drugs ◽

Dose Combination ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

Orthopedic Patients

Objective: Many Fix Dose Combinations (FDCs) being introduced in India are usually irrational. The most pressing concern with irrational FDCs is that they expose patients to unnecessary risk of adverse drug reactions, for instance, pediatric formulations of nimesulide+paracetamol. Despite their wide clinical use, their gastro-intestinal toxicity is a major limitation. The aim of the present work was to evaluate the efficacy and safety of FDCs in non-steroidal anti-inflammatory drugs in the orthopedic department at a tertiary care teaching hospital. To study the effectiveness and safety parameters of fixed-dose combinations of Non-Steroidal Anti-inflammatory Drugs. Methods: This prospective, observational study was conducted among 150 out-patients of the orthopedic ward over a period of July 2013 to December 2013(Each combination with 50 patients). Three fixed-dose combinations utilized were paracetamol+diclofenac, paracetamol+ibuprofen and paracetamol+nimesulide. The effectiveness was analyzed by using Visual Analogue Scale (VAS) and Disease Activity Scale (DAS) and the safety criteria were analyzed by using the WHO probability scale and Naranjo scale. 150 orthopedic patients attending Out Patient Department were included. 50 participants for each of the combinations of fixed-dose combination (FDCs) of NSAIDs. Results: Out of 150 patients 33 patients developed adverse effects, and 17(51.51%) adverse effects due to the combination of Paracetmol+Nimuselide, 11(33.34%) adverse effects due to the Paracetamol+Ibuprofen and 5 (15.15%) were due to the combination of Paracetamol+Diclofenac. The maximum effectiveness (3.55±0.208) showed in the combination of paracetamol+diclofenac compared to the other two combinations. Conclusion: It was concluded from this study that the effectiveness and safety profile of PCM+DICLO is better than the other two FDCs.

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Synthesis and Biological Evaluation of Derivatives of 2-{2-Fluoro-4-[(2-oxocyclopentyl)methyl]phenyl}propanoic Acid: Nonsteroidal Anti-Inflammatory Drugs with Low Gastric Ulcerogenic Activity

Journal of Medicinal Chemistry ◽

10.1021/jm300049g ◽

2012 ◽

Vol 55 (11) ◽

pp. 5143-5150 ◽

Cited By ~ 17

Author(s):

Naoki Yamakawa ◽

Shintaro Suemasu ◽

Yoshinari Okamoto ◽

Ken-ichiro Tanaka ◽

Tomoaki Ishihara ◽

...

Keyword(s):

Biological Evaluation ◽

Propanoic Acid ◽

Ulcerogenic Activity ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

Synthesis And Biological Evaluation ◽

Derivatives Of ◽

Methyl Phenyl

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N,N-Dimethylformamide Prevents LPS-Induced Preterm Birth in a Murine Model by Suppressing the Inflammatory Response

10.21203/rs.3.rs-969393/v1 ◽

2021 ◽

Author(s):

Zeng-Hui Wei ◽

Oluwabukola Salami ◽

Jagadish Koya ◽

Swapna Munnangi ◽

Ryan Pekson ◽

...

Keyword(s):

Preterm Birth ◽

Murine Model ◽

Raw 264.7 Cells ◽

New Approach ◽

Affect Cell Viability ◽

Pregnant Mice ◽

Inflammatory Drugs ◽

The Common ◽

Anti Inflammatory

Abstract Preterm birth accounts for the majority of perinatal mortality worldwide and there remains no FDA-approved drug to prevent it. Recently, we discovered that the common drug excipient, N,N-dimethylacetamide (DMA), prevents inflammation–induced preterm birth in mice by inhibiting NF-κB. Since we reported this finding it has come to light that a group of widely used, structurally related aprotic solvents, including DMA, N-methyl-2-pyrrolidone (NMP) and dimethylformamide (DMF), have anti-inflammatory efficacy. We show here that DMF suppresses LPS-induced TNFα secretion from RAW 264.7 cells and IL-6 and IL-8 secretion from HTR-8 cells at concentrations that do not significantly affect cell viability. In vivo, DMF decreases LPS-induced inflammatory cell infiltration and expression of TNFα and IL-6 in the placental labyrinth, all to near baseline levels. Finally, DMF decreases the rate of preterm birth in LPS-induced pregnant mice (P<.0001) and the rate at which pups are spontaneously aborted (P<.0001). In summary, DMF, a widely used solvent structurally related to DMA and NMP, prevents LPS-induced preterm birth in a murine model without overt toxic or teratogenic effects. Re-purposing the DMA/DMF/NMP family of small molecules as anti-inflammatory drugs is a promising new approach to preventing inflammation–induced preterm birth and potentially other inflammatory disorders as well.

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Recent Findings in Molecular Basis of Inflammation and Anti-inflammatory Plants

Current Pharmaceutical Design ◽

10.2174/1381612824666180403122003 ◽

2018 ◽

Vol 24 (14) ◽

pp. 1551-1562 ◽

Cited By ~ 7

Author(s):

Sedigheh Kazemi ◽

Hedayatollah Shirzad ◽

Mahmoud Rafieian-Kopaei

Keyword(s):

Medicinal Plants ◽

Molecular Basis ◽

Acute Inflammation ◽

Antiinflammatory Drugs ◽

Multiple Organs ◽

Novel Drugs ◽

Substantial Progress ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

Made In

Inflammation is one of the most important body responses provided by the immune system since it ensures survival when tissues are affected by injuries or infections. The inflammatory response is an important process for maintenance of normal tissue homeostasis. In contrast to acute inflammation, chronic inflammation does not have a useful impact. Prevention and suppression of inflammation are necessary to reduce patient suffering and to preserve the integrity of multiple organs. Unfortunately, commercial available anti-inflammatory drugs are not free from side effects. Hence, there is an urgent need for introducing potent, nontoxic or less toxic antiinflammatory drugs. Recently, substantial progress has been made in the understanding of inflammatory mechanisms which may open new avenues for the preparation of novel anti-inflammatory drugs. Medicinal plants are also promising sources for preparation of such novel drugs. Taking into consideration the anti-inflammatory activities of a large group of medicinal plants, this article, in addition to describing recent advances in progress in understanding the molecular basis of inflammation, presents the most important medicinal plants with antiinflammatory activity.

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Evaluation of the Anti-Inflammatory Activities of Diclofenac Sodium, Prednisolone and Atorvastatin in Combination with Ascorbic Acid

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry ◽

10.2174/1871523018666190514112048 ◽

2020 ◽

Vol 19 (3) ◽

pp. 291-301 ◽

Cited By ~ 3

Author(s):

Tanvir Ahmed ◽

Sabrina Rahman Archie ◽

Asef Faruk ◽

Fabliha Ahmed Chowdhury ◽

Abdullah Al Shoyaib ◽

...

Keyword(s):

Ascorbic Acid ◽

Defense Mechanism ◽

Diclofenac Sodium ◽

Antiinflammatory Drugs ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

Inflammation Group ◽

Neuropsychiatric Effect ◽

Normal Defense

Objectives: Inflammation is our body’s normal defense mechanism, but in some cases, it may be responsible for causing different kinds of disorders. Several antiinflammatory drugs are present for the treatment of these disorders; however, the conventional anti-inflammatory drugs cause side effects when used in the long term and therefore, it is better to use them in a low dose for a shorter duration of time. This study was designed to find out whether there is an augmentation of the therapeutic effectiveness of the antiinflammatory drugs like diclofenac sodium (NSAID), prednisolone (steroid) and atorvastatin (statin) when used in combination with ascorbic acid (antioxidant). Methods: Wistar Rats (n=144) were selected and divided into 24 groups of 6 rats in each. Carrageenan and formalin were used to induce local inflammation and neuropsychiatric effects, respectively. The inhibitions of such responses were measured after administering a drug alone and in combination with ascorbic acid. Results: In case of carrageenan mediated inflammation, the combination of 5 mg/kg diclofenac and 200 mg/kg ascorbic acid gave the highest inhibition of 74.19% compared to other groups of drugs. The combination of 5 mg/kg diclofenac and 200 mg/kg ascorbic acid gave 97.25% inhibition for formalin-mediated inflammation group. In both cases, combination therapy showed statistically significant anti-inflammatory activities compared to monotherapy (p values <0.05). Conclusion: All the data clearly indicate new combinations of drug therapy comprising diclofenac sodium, prednisolone, atorvastatin with ascorbic acid, which may be more effective against both local edema and the neuropsychiatric effect caused due to inflammation.

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