A Gastroscopic and Histological Double-Blind Study of the Effects of Diclofenac Sodium and Naproxen on the Human Gastric Mucosa

1977 ◽  
Vol 6 (2) ◽  
pp. 97-102 ◽  
Author(s):  
J. Lehtola ◽  
P. Sipponen
1992 ◽  
Vol 32 (2) ◽  
pp. 98-100 ◽  
Author(s):  
George N. Karachalios ◽  
Adroniki Fotiadou ◽  
Nickolaos Chrisikos ◽  
Alexandros Karabetsos ◽  
Kyriakos Kehagioglou

2017 ◽  
Vol 09 (06) ◽  
Author(s):  
Gonzalez Delgado CA ◽  
Padron Yaquis AS ◽  
Jimenez Rodriguez D ◽  
Cazanave Guarnaluce D ◽  
Alejo Cisneros PL ◽  
...  

2017 ◽  
Vol 2017 ◽  
pp. 1-1
Author(s):  
Gita Faghihi ◽  
Azam Elahipoor ◽  
Fariba Iraji ◽  
Shadi Behfar ◽  
Bahareh Abtahi-Naeini ◽  
...  

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Gita Faghihi ◽  
Azam Elahipoor ◽  
Fariba Iraji ◽  
Shadi Behfar ◽  
Bahareh Abtahi-Naeini

Introduction. Actinic keratoses (AKs), a premalignant skin lesion, are a common lesion in fair skin. Although destructive treatment remains the gold standard for AKs, medical therapies may be preferable due to the comfort and reliability .This study aims to compare the effects of topical 1% colchicine gel and 3% diclofenac sodium gel in AKs.Materials and Methods. In this randomized double-blind study, 70 lesions were selected. Patients were randomized before receiving either 1% colchicine gel or 3% diclofenac sodium cream twice a day for 6 weeks. Patients were evaluated in terms of their lesion size, treatment complications, and recurrence at 7, 30, 60, and 120 days after treatment.Results. The mean of changes in the size was significant in both groups both before and after treatment (<0.001). The mean lesion size before treatment and at 30, 60, and 120 days was not different between the two groups (p> 0.05). No case of erythema was seen in the colchicine group, while erythema was seen in 22.9% (eight cases) of patients in the diclofenac sodium group (p= 0.005).Conclusions. 1% colchicine gel was a safe and effective medication with fewer side effects and lack of recurrence of the lesion.


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