Topical Colchicine Gel versus Diclofenac Sodium Gel for the Treatment of Actinic Keratoses: A Randomized, Double-Blind Study

Introduction. Actinic keratoses (AKs), a premalignant skin lesion, are a common lesion in fair skin. Although destructive treatment remains the gold standard for AKs, medical therapies may be preferable due to the comfort and reliability .This study aims to compare the effects of topical 1% colchicine gel and 3% diclofenac sodium gel in AKs.Materials and Methods. In this randomized double-blind study, 70 lesions were selected. Patients were randomized before receiving either 1% colchicine gel or 3% diclofenac sodium cream twice a day for 6 weeks. Patients were evaluated in terms of their lesion size, treatment complications, and recurrence at 7, 30, 60, and 120 days after treatment.Results. The mean of changes in the size was significant in both groups both before and after treatment (<0.001). The mean lesion size before treatment and at 30, 60, and 120 days was not different between the two groups (p> 0.05). No case of erythema was seen in the colchicine group, while erythema was seen in 22.9% (eight cases) of patients in the diclofenac sodium group (p= 0.005).Conclusions. 1% colchicine gel was a safe and effective medication with fewer side effects and lack of recurrence of the lesion.

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Corrigendum to “Topical Colchicine Gel versus Diclofenac Sodium Gel for the Treatment of Actinic Keratoses: A Randomized, Double-Blind Study”

Advances in Medicine ◽

10.1155/2017/7192180 ◽

2017 ◽

Vol 2017 ◽

pp. 1-1

Author(s):

Gita Faghihi ◽

Azam Elahipoor ◽

Fariba Iraji ◽

Shadi Behfar ◽

Bahareh Abtahi-Naeini ◽

...

Keyword(s):

Diclofenac Sodium ◽

Blind Study ◽

Double Blind Study ◽

Double Blind ◽

Actinic Keratoses

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A Double Blind Study Comparing The Efficacy of Ibuprofen,Diclofenac Sodium and Placebo on Lipid Peroxide- Malondialdehyde Levels in Gingival Tissue Before and After Periodontal Surgery

Biosciences Biotechnology Research Asia ◽

10.13005/bbra/1817 ◽

2015 ◽

Vol 12 (2) ◽

pp. 1561-1565

Author(s):

G. Balaji Babu ◽

A. Raja ◽

R. Saranyan ◽

Majo Ambooken ◽

B. Manovijay ◽

...

Keyword(s):

Diclofenac Sodium ◽

Lipid Peroxide ◽

Blind Study ◽

Gingival Tissue ◽

Double Blind Study ◽

Periodontal Surgery ◽

Double Blind ◽

Before And After

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Treatment of Acute Migraine Attack With Diclofenac Sodium: A Double-Blind Study

Headache The Journal of Head and Face Pain ◽

10.1111/j.1526-4610.1992.hed3202098.x ◽

1992 ◽

Vol 32 (2) ◽

pp. 98-100 ◽

Cited By ~ 24

Author(s):

George N. Karachalios ◽

Adroniki Fotiadou ◽

Nickolaos Chrisikos ◽

Alexandros Karabetsos ◽

Kyriakos Kehagioglou

Keyword(s):

Migraine Attack ◽

Diclofenac Sodium ◽

Blind Study ◽

Double Blind Study ◽

Acute Migraine ◽

Double Blind ◽

Acute Migraine Attack

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Comparison of a New Hypnotic (Finorgal) with Placebo in a Double-Blind Trial

Journal of International Medical Research ◽

10.1177/030006057900700510 ◽

1979 ◽

Vol 7 (5) ◽

pp. 387-390

Author(s):

Gianni Baiotti

Keyword(s):

Placebo Treatment ◽

Blind Study ◽

Double Blind Study ◽

Double Blind Trial ◽

Double Blind ◽

Blind Trial ◽

The Mean ◽

Mean Time

The hypnotic effects of Finorgal (ethchlorvynol with diphenhydramine) were compared with those of placebo in a double-blind study with crossover of treatments in thirty-five hospital in-patients. During the four-week period of Finorgal treatment there was a significant reduction in the mean time elapsing between the administration of the hypnotic and the onset of sleep, and a significant increase in the duration of sleep, compared with the four weeks of placebo treatment. There was also a significant increase in the proportion of nights when the patients felt they had slept well, and in the incidence of morning ‘hangover’ and nocturnal confusion during the Finorgal treatment periods. Patients had to be actively woken in the morning significantly more often following Finorgal administration. In patients experiencing pain in the night there was a significant reduction in the occurrence of pain during the nights when Finorgal had been given.

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The role of tolvaptan in prevention of hyponatremia in patients undergoing transurethral resection of prostate surgery- A randomized double blind study

Indian Journal of Clinical Anaesthesia ◽

10.18231/j.ijca.2021.059 ◽

2021 ◽

Vol 8 (2) ◽

pp. 321-325

Author(s):

Dinesh Kumar Singh ◽

B B Baj ◽

Vipin Goyal

Keyword(s):

Transurethral Resection ◽

Blind Study ◽

Transurethral Resection Of Prostate ◽

Double Blind Study ◽

Double Blind ◽

Significant Difference ◽

Group A ◽

The Mean ◽

Group B

The aim of our study to determine the role of tolvaptan in prevention of hyponatremia in transurethral resection of prostate surgery. This is randomized double-blind study conducted in 60 ASA grade status 1 and 2 patients age group between 45-80 yrs undergoing TURP under spinal anaesthesia in urology operation theatre in Mahatma Gandhi hospital Jaipur after receiving permission from hospital ethical committee. A detailed history, complete physical examination and routine investigation were done for all patients followed by informed written consent was obtained. Patients are randomly divided into 2 groups. In group A -30 patients who received orally tab tolvaptan 15 mg and group B-30 patients who received orally tab multivitamin 2 hrs before surgery after doing electrolytes of the patients in the morning. In both groups age (in yrs), wt (in kg), ASA grade, volume of irrigating fluid (in litres), volume of prostate resected (in gm) and duration of surgery (in minutes) all demographic and surgical details data were compared. Electrolytes were compared in both groups pre and post-operatively and statistical analysis was done.There was significant difference in post-operative sodium level between the two groups (A and B). The mean level of sodium significantly reduced post-operatively in group –B (control grp). The mean level of sodium significantly increased post-operatively in group –A (tolvaptan grp). We conclude single dose of tolvaptan -15 mg found to effective in prevention of hyponatremia in patients undergoing TURP.

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