The Endothelium-dependent, Substance P Relaxation of Porcine Coronary Arteries Resistant to Nitric Oxide Synthesis Inhibition is Partially Mediated by 4-Aminopyridine-sensitive Voltage-dependent K+Channels

Endothelium ◽  
1997 ◽  
Vol 5 (4) ◽  
pp. 287-295 ◽  
Author(s):  
Shunichi Shimizu ◽  
Richard J. Paul
Keyword(s):  
Nitric Oxide ◽  
Substance P ◽  
Coronary Arteries ◽  
Nitric Oxide Synthesis ◽  
K Channels ◽  
Synthesis Inhibition ◽  
Voltage Dependent

Effects of Long-term Nitric Oxide Synthesis Inhibition on Plasma Volume Expansion and Fetal Growth in the Pregnant Rat

Hypertension ◽  
1995 ◽  
Vol 26 (6) ◽  
pp. 1019-1023 ◽  
Author(s):  
Sofía P. Salas ◽  
Fernando Altermatt ◽  
Mauricio Campos ◽  
Andrea Giacaman ◽  
Pedro Rosso
Keyword(s):  
Nitric Oxide ◽  
Fetal Growth ◽  
Plasma Volume ◽  
Volume Expansion ◽  
Nitric Oxide Synthesis ◽  
Plasma Volume Expansion ◽  
Pregnant Rat ◽  
Synthesis Inhibition

Nitric Oxide Synthesis Inhibition during Cerebral Hypoxemia and Reoxygenation with 100% Oxygen in Newborn Pigs

Neonatology ◽  
2002 ◽  
Vol 82 (3) ◽  
pp. 197-206 ◽  
Author(s):  
Stefan Kutzsche ◽  
Anne-Beate Solas ◽  
Torstein Lyberg ◽  
Ola D. Saugstad
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthesis ◽  
Synthesis Inhibition ◽  
Newborn Pigs

Nitric oxide synthesis inhibition: The effect on rabbit pyloric muscle

1996 ◽  
Vol 31 (6) ◽  
pp. 800-804 ◽  
Author(s):  
Enrique Grisoni ◽  
Dan Dusleag ◽  
Dennis Super
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthesis ◽  
Synthesis Inhibition ◽  
Pyloric Muscle

Tonic regulation of vascular tone by nitric oxide and chloride ions in rat isolated small coronary arteries

2000 ◽  
Vol 279 (6) ◽  
pp. H2604-H2611 ◽  
Author(s):  
Jonathan E. Graves ◽  
Iain A. Greenwood ◽  
William A. Large
Keyword(s):  
Nitric Oxide ◽  
Coronary Arteries ◽  
Vascular Tone ◽  
Physiological Saline ◽  
Chloride Ions ◽  
Bathing Solution ◽  
Contractile Mechanism ◽  
Mechanical Removal ◽  
Voltage Dependent ◽  
Physiological Saline Solution

We have investigated the involvement of Cl− in regulating vascular tone in rat isolated coronary arteries mounted on a small vessel myograph. Mechanical removal of the endothelium or inhibition of nitric oxide (NO) synthase with N ω-nitro-l-arginine methyl ester (l-NAME, 10−4 M) led to contraction of rat coronary arteries, and these contractions were sensitive to nicardipine (10−6 M). This suggests that release of NO tonically inhibits a contractile mechanism that involves voltage-dependent Ca2+ channels. In arteries contracted withl-NAME, switching the bathing solution to physiological saline solution with a reduced Cl− concentration potentiated the contraction. DIDS (5 × 10−6–3 × 10−4 M) caused relaxation of l-NAME-induced tension (IC50 = 55 ± 10 μM), providing evidence for a role of Cl−. SITS (10−5–5 × 10−4 M) did not affectl-NAME-induced tension, suggesting that DIDS is not acting by inhibition of anion exchange. Mechanical removal of the endothelium led to contraction of arteries, which was sensitive to DIDS (IC50 = 50 ± 8 μM) and was not affected by SITS. This study suggests that, in rat coronary arteries, NO tonically suppresses a contractile mechanism that involves a Cl−conductance.

Effects of chronic increased salt intake on nitric oxide synthesis inhibition-induced hypertension

1995 ◽  
Vol 13 (1) ◽  
pp. 123???128 ◽  
Author(s):  
Antonio Fern??ndez-Rivas ◽  
Joaqu??n Garc??a-Esta?? ◽  
F??lix Vargas
Keyword(s):  
Nitric Oxide ◽  
Salt Intake ◽  
Nitric Oxide Synthesis ◽  
Synthesis Inhibition ◽  
Induced Hypertension

scholarly journals Hypertension induced by nitric oxide synthesis inhibition is renal nerve dependent.

Hypertension ◽  
1994 ◽  
Vol 23 (6_pt_2) ◽  
pp. 971-975 ◽  
Author(s):  
H Matsuoka ◽  
H Nishida ◽  
G Nomura ◽  
B N Van Vliet ◽  
H Toshima
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthesis ◽  
Renal Nerve ◽  
Synthesis Inhibition

scholarly journals Effects of nitric oxide synthesis inhibition on the goat coronary circulation under basal conditions and after vasodilator stimulation

1992 ◽  
Vol 106 (3) ◽  
pp. 563-567 ◽  
Author(s):  
J.L. García ◽  
N. Fernández ◽  
A.L. García-Villalón ◽  
L. Monge ◽  
B. Gómez ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Coronary Circulation ◽  
Nitric Oxide Synthesis ◽  
Synthesis Inhibition

Nitric oxide synthesis inhibition attenuates behavioral actions of neuropeptide FF

Peptides ◽  
1996 ◽  
Vol 17 (4) ◽  
pp. 615-618 ◽  
Author(s):  
David H. Malin ◽  
J. Ronald Lake ◽  
Jeffrey A. Jones ◽  
Jane Morel ◽  
William D. Moon ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthesis ◽  
Synthesis Inhibition ◽  
Neuropeptide Ff
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