α-Phenyl N-Tert-Butyl Nitrone (PBN) Increases the Cortical Cerebral Blood Flow by Inhibiting the Breakdown of Nitric Oxide in Anesthetized Rats

1995 ◽  
Vol 23 (1) ◽  
pp. 33-39 ◽  
Author(s):  
Osamu Inanami ◽  
Mikinori Kuwabara
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Tert Butyl ◽  
Anesthetized Rats ◽  
Cortical Cerebral Blood Flow

Effect of acupuncture-like stimulation on cortical cerebral blood flow in anesthetized rats

2002 ◽  
Vol 1238 ◽  
pp. 89-96 ◽  
Author(s):  
Sae Uchida ◽  
Atsuko Suzuki ◽  
Fusako Kagitani ◽  
Yoshihiro Aikawa
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Anesthetized Rats ◽  
Cortical Cerebral Blood Flow

scholarly journals Effect of Acupuncture-Like Stimulation on Cortical Cerebral Blood Flow in Anesthetized Rats.

2000 ◽  
Vol 50 (5) ◽  
pp. 495-507 ◽  
Author(s):  
Sae Uchida ◽  
Fusako Kagitani ◽  
Atsuko Suzuki ◽  
Yoshihiro Aikawa
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Anesthetized Rats ◽  
Cortical Cerebral Blood Flow

Effect of L-NMMA, cromakalim, and glibenclamide on cerebral blood flow in hypercapnia and hypoxia

1995 ◽  
Vol 269 (3) ◽  
pp. H916-H922 ◽  
Author(s):  
J. M. Reid ◽  
A. G. Davies ◽  
F. M. Ashcroft ◽  
D. J. Paterson
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Combined Effects ◽  
Arterial Pco2 ◽  
Anesthetized Rats ◽  
Adenosine Antagonist ◽  
Arterial Po2 ◽  
Hydrogen Clearance ◽  
Clearance Technique

Sulfonylureas reduce cerebral blood flow (CBF) during hypoxia but not during hypercapnia, whereas blockers of nitric oxide (NO) synthesis reduce hypercapnic CBF. However, the effect of NO blockers on hypoxic CBF is uncertain. CBF was measured in the cortex of 51 enflurane-anesthetized rats by the hydrogen clearance technique during eucapnia, hypercapnia (arterial PCO2 65 Torr), and hypoxia (arterial PO2 40 Torr). CBF increased twofold in both hypercapnia and hypoxia from eucapnia. Intracortical (ic) NG-monomethyl-L-arginine (L-NMMA, 100 microM-5 mM) attenuated both the hypercapnic and hypoxic dilations by 60-70%, and L-arginine (300 mg/kg iv) partially reversed these effects. Glibenclamide (10 microM ic) and L-NMMA gave no further attenuation of the hypoxic dilation than L-NMMA alone. Cromakalim (10 microM, ic) increased CBF in eucapnia, but this was not seen in the presence of glibenclamide. The adenosine antagonist 8-phenyl-theophylline did not attenuate the hypoxic dilation. This suggests that NO synthesis plays a major role in the regulation of CBF in hypercapnia and hypoxia. But the combined effects of glibenclamide and L-NMMA do not further attenuate CBF in hypoxia.

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