Pathologic Features of Gastrointestinal Tract Lesions in Childhood-Onset Systemic Lupus Erythematosus

1987 ◽  
Vol 7 (3) ◽  
pp. 245-259 ◽  
Author(s):  
Rosario Nadorra ◽  
Yutaka Nakazato ◽  
Benjamin Landing
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Gastrointestinal Tract ◽  
Lupus Erythematosus ◽  
Childhood Onset ◽  
Systemic Lupus ◽  
Pathologic Features ◽  
Onset Systemic Lupus Erythematosus

scholarly journals Clinical and laboratory manifestations of childhood and adult-onset systemic lupus erythematosus in Cipto Mangunkusumo Hospital

2016 ◽  
Vol 43 (6) ◽  
pp. 199
Author(s):  
Syarif Faisal ◽  
Arwin Akib ◽  
Taralan Tambunan
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Retrospective Study ◽  
Gastrointestinal Tract ◽  
Child Health ◽  
Lupus Erythematosus ◽  
Adult Onset ◽  
Childhood Onset ◽  
Systemic Lupus ◽  
Pediatric Allergy ◽  
Onset Systemic Lupus Erythematosus

Background Childhood-onset SLE is more severe than the adult type.Objective To compare the clinical and laboratory manifestationsof childhood- and adult-onset systemic lupus erythematosus (SLE).Methods A retrospective study on child and adult SLE patientswas conducted in the Division of Pediatric Allergy and Immunol-ogy, Department of Child Health and Department of Internal Medi-cine, Medical School, University of Indonesia/CiptoMangunkusumoHospital (FKUI/RSCM) Jakarta.Subjects One hundred and twenty-nine subjects met the studycriteria consisting on 54 childhood- onset (41.9%), 75 adult-onset(58.1%), and 122 (94.6%) females and 7 (5.4%) males from Janu-ary 1995 until December 2000.Results Fever, arthralgia and vasculitis were the most frequentsigns found in both childhood-onset and adult-onset SLE. The liver,spleen, lymph nodes, cardiovascular, gastrointestinal tract, andeyes were the organs involved and significantly had a larger pro-portion in the childhood-onset. Decrease of C3 was more frequentlyfound in the childhood-onset. Out of 17 childhood-onset patientswho died, 13 died at the age of 0-11 year-old. Two of the adult-onset patients also died.Conclusion Childhood-onset SLE had some different character-istics compared to adult form

scholarly journals An Update on the Management of Childhood-Onset Systemic Lupus Erythematosus

2021 ◽  
Author(s):  
Vitor Cavalcanti Trindade ◽  
Magda Carneiro-Sampaio ◽  
Eloisa Bonfa ◽  
Clovis Artur Silva
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Childhood Onset ◽  
Systemic Lupus ◽  
Onset Systemic Lupus Erythematosus

scholarly journals Social phobia in childhood-onset systemic lupus erythematosus

2014 ◽  
Vol 12 (Suppl 1) ◽  
pp. P333
Author(s):  
Catia Nascimento ◽  
Renata Barbosa ◽  
Luciana Oliveira ◽  
Karina Peliçari ◽  
Nailu Sinicato ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Social Phobia ◽  
Lupus Erythematosus ◽  
Childhood Onset ◽  
Systemic Lupus ◽  
Onset Systemic Lupus Erythematosus

scholarly journals Depression and medication nonadherence in childhood-onset systemic lupus erythematosus

Lupus ◽  
2018 ◽  
Vol 27 (9) ◽  
pp. 1532-1541 ◽  
Author(s):  
A M Davis ◽  
T B Graham ◽  
Y Zhu ◽  
M L McPheeters
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Medication Adherence ◽  
Lupus Erythematosus ◽  
Depression Symptoms ◽  
Childhood Onset ◽  
Systemic Lupus ◽  
Medication Nonadherence ◽  
Disease Characteristics ◽  
Prevalence Of Depression ◽  
Onset Systemic Lupus Erythematosus

Objectives Depression and medication nonadherence are important in managing chronic diseases, but little is known about these factors in childhood-onset systemic lupus erythematosus (cSLE). The objectives of this cross-sectional study were to estimate prevalence of depression and medication nonadherence, describe demographic and disease characteristics associated with depression and medication nonadherence, and evaluate the association between depression and medication nonadherence in cSLE patients. Methods Patients with cSLE ( n = 51) completed validated screening questionnaires to identify depression and medication nonadherence, Patient Health Questionnaire-9 and Medication Adherence Self-Report Inventory, respectively. Demographic and disease characteristics were obtained via chart abstraction, and compared between groups of depression or medication nonadherence status. A multivariable linear regression model adjusting for propensity scores was conducted to evaluate the association between depression and medication nonadherence. Results The prevalence of a positive depression screen was 58.8%, and seven patients reported suicidal ideation (13.7%). The prevalence of self-reported medication nonadherence was 19.7%. No statistically significant differences for demographic and disease characteristics were found between patients with a positive vs. negative depression screen. Patients reporting medication nonadherence were more likely to have longer disease duration (4.8 vs. 2.6 years, p = 0.035). As the severity of depression symptoms increased, the degree of medication nonadherence also increased (beta = –1.89; p = 0.011). Conclusions The prevalence of depression and medication nonadherence is high in cSLE, and these factors have a direct relationship. Interventions that better recognize and treat depression and increase rates of medication adherence are needed to improve outcomes in cSLE.

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