Telomerase-associated protein TEP1 is differentially expressed in brain metastatic breast cancer.
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Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes to discover genes associated with brain metastasis in patients with metastatic breast cancer. We found that the telomerase-associated protein encoded by TEP1 (6) was among the genes whose expression was most different in the brain metastases of patients with brain metastatic breast cancer as compared to primary tumors of the breast. TEP1 may be relevant to processes underlying metastasis of primary tumor-derived cancer cells to the brain in humans with metastatic breast cancer.
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