scholarly journals Over-expression of ADP ribosylation factor like GTPase 4C in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Adp Ribosylation ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Tumor Expression ◽  
Adp Ribosylation Factor

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published and public microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified ADP ribosylation factor like GTPase 4C, encoded by ARL4C, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. ARL4C was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of ARL4C was correlated with recurrence-free survival in white patients with high mutational burden. ARL4C may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of cytoskeleton associated protein 2 in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Mutational Burden ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified cytoskeleton associated protein 2, encoded by CKAP2, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. CKAP2 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of CKAP2 was correlated with recurrence-free survival in white patients with high and low mutational burden. CKAP2 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of KIAA0101 (PCLAF) in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Microarray Data ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified KIAA0101, also known as the PCNA clamp-associated factor (PCLAF) as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. KIAA0101 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, primary tumor expression of KIAA0101 was correlated with recurrence-free survival in patients with endometrial cancer. KIAA0101 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of diazepam binding inhibitor, acyl-CoA binding protein in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Binding Protein ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Black Patients ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified diazepam binding inhibitor, acyl-CoA binding protein, encoded by DBI, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. DBI was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of DBI was correlated with recurrence-free survival in black patients with low mutational burden. DBI may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of MLX, MAX dimerization protein in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Mutational Burden ◽  
Black Patients ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified MLX, MAX dimerization protein, encoded by MLX, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. MLX was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of MLX was correlated with recurrence-free survival in black patients with low mutational burden. MLX may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of mitochondrial phosphoenolpyruvate carboxykinase 2 in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Phosphoenolpyruvate Carboxykinase ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Black Patients ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified phosphoenolpyruvate carboxykinase 2, mitochondrial, encoded by PCK2, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. PCK2 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of PCK2 was correlated with recurrence-free survival in black patients with high mutational burden. PCK2 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of centromere protein U in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Mutational Burden ◽  
Centromere Protein ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified centromere protein U, encoded by CENPU, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. CENPU was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of CENPU was correlated with recurrence-free survival in white patients with low mutational burden. CENPU may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of propionyl-CoA carboxylase beta subunit in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Beta Subunit ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Mutational Burden ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified propionyl-CoA carboxylase beta subunit, encoded by PCCB, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. PCCB was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of PCCB was correlated with recurrence-free survival in white patients with low mutational burden. PCCB may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of nucleolar and spindle associated protein 1 in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Microarray Data ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified nucleolar and spindle associated protein 1, encoded by NUSAP1, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. NUSAP1 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, primary tumor expression of NUSAP1 was correlated with recurrence-free survival in patients with endometrial cancer. NUSAP1 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of ISG15 ubiquitin-like modifier in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Microarray Data ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified ISG15 ubiquitin-like modifier, encoded by ISG15, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. ISG15 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, primary tumor expression of ISG15 was correlated with recurrence-free survival in patients with endometrial cancer. ISG15 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of pyrophosphatase (inorganic) 1 in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Mutational Burden ◽  
Black Patients ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified pyrophosphatase (inorganic) 1, encoded by PPA1, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. PPA1 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of PPA1 was correlated with recurrence-free survival in black patients with low mutational burden. PPA1 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

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