scholarly journals Differential expression of cyclin B2 in human epithelial ovarian cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Fallopian Tube ◽  
Expression Profiles ◽  
Gynecologic Cancer ◽  
Gene Expression Profiles ◽  
Global Gene Expression ◽  
High Grade ◽  
Primary Tumors ◽  
Ovarian Cancers

Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer (1). We performed discovery of genes associated with epithelial ovarian cancer and of the high-grade serous ovarian cancer (HGSC) subtype, using published microarray data (2, 3) to compare global gene expression profiles of normal ovary or fallopian tube with that of primary tumors from women diagnosed with epithelial ovarian cancer or HGSC. We identified the gene encoding cyclin B2, CCNB2, as among the genes whose expression was most different in epithelial ovarian cancer as compared to the normal fallopian tube. CCNB2 expression was significantly higher in high-grade serous ovarian tumors relative to normal fallopian tube. These data indicate that expression of CCNB2 is perturbed in epithelial ovarian cancers broadly and in ovarian cancers of the HGSC subtype. CCNB2 may be relevant to pathways underlying ovarian cancer initiation (transformation) or progression.

scholarly journals Differential expression of tropomyosin 3 in human epithelial ovarian cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Fallopian Tube ◽  
Expression Profiles ◽  
Gynecologic Cancer ◽  
Gene Expression Profiles ◽  
Global Gene Expression ◽  
High Grade ◽  
Primary Tumors ◽  
Ovarian Cancers

Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer (1). We performed discovery of genes associated with epithelial ovarian cancer and of the high-grade serous ovarian cancer (HGSC) subtype, using published microarray data (2, 3) to compare global gene expression profiles of normal ovary or fallopian tube with that of primary tumors from women diagnosed with epithelial ovarian cancer or HGSC. We identified the gene encoding tropomyosin 3, TPM3, as among the genes whose expression was most different in epithelial ovarian cancer as compared to the normal fallopian tube. TPM3 expression was significantly higher in high-grade serous ovarian tumors relative to normal fallopian tube. TPM3 expression correlated with overall survival in patients with ovarian cancer. These data indicate that expression of TPM3 is perturbed in epithelial ovarian cancers broadly and in ovarian cancers of the HGSC subtype. TPM3 may be relevant to pathways underlying ovarian cancer initiation (transformation) or progression.

scholarly journals Differential expression of coronin 6 in human epithelial ovarian cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Fallopian Tube ◽  
Expression Profiles ◽  
Gynecologic Cancer ◽  
Gene Expression Profiles ◽  
Global Gene Expression ◽  
High Grade ◽  
Primary Tumors ◽  
Ovarian Cancers

Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer (1). We performed discovery of genes associated with epithelial ovarian cancer and of the high-grade serous ovarian cancer (HGSC) subtype, using published microarray data (2, 3) to compare global gene expression profiles of normal ovary or fallopian tube with that of primary tumors from women diagnosed with epithelial ovarian cancer or HGSC. We identified the gene encoding coronin 6, CORO6, as among the genes whose expression was most different in epithelial ovarian cancer as compared to the normal fallopian tube. CORO6 expression was significantly lower in high-grade serous ovarian tumors relative to normal fallopian tube. CORO6 expression correlated with overall survival in patients with ovarian cancer. These data indicate that expression of CORO6 is perturbed in epithelial ovarian cancers broadly and in ovarian cancers of the HGSC subtype. CORO6 may be relevant to pathways underlying ovarian cancer initiation (transformation) or progression.

scholarly journals Differential expression of versican in human epithelial ovarian cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Fallopian Tube ◽  
Expression Profiles ◽  
Gynecologic Cancer ◽  
Gene Expression Profiles ◽  
Global Gene Expression ◽  
High Grade ◽  
Primary Tumors ◽  
Ovarian Cancers

Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer (1). We performed discovery of genes associated with epithelial ovarian cancer and of the high-grade serous ovarian cancer (HGSC) subtype, using published microarray data (2, 3) to compare global gene expression profiles of normal ovary or fallopian tube with that of primary tumors from women diagnosed with epithelial ovarian cancer or HGSC. We identified the gene encoding versican, VCAN, as among the genes whose expression was most different in epithelial ovarian cancer as compared to the normal fallopian tube. VCAN expression was significantly higher in high-grade serous ovarian tumors relative to normal fallopian tube. VCAN expression correlated with overall survival in patients with ovarian cancer. These data indicate that expression of VCAN is perturbed in epithelial ovarian cancers broadly and in ovarian cancers of the HGSC subtype. VCAN may be relevant to pathways underlying ovarian cancer initiation (transformation) or progression.

scholarly journals Differential expression of 4-hydroxyphenylpyruvate dioxygenase-like in human epithelial ovarian cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Fallopian Tube ◽  
Expression Profiles ◽  
Gynecologic Cancer ◽  
Gene Expression Profiles ◽  
Global Gene Expression ◽  
High Grade ◽  
Primary Tumors ◽  
Ovarian Cancers

Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer (1). We performed discovery of genes associated with epithelial ovarian cancer and of the high-grade serous ovarian cancer (HGSC) subtype, using published microarray data (2, 3) to compare global gene expression profiles of normal ovary or fallopian tube with that of primary tumors from women diagnosed with epithelial ovarian cancer or HGSC. We identified the gene encoding 4-hydroxyphenylpyruvate dioxygenase-like, HPDL, as among the genes whose expression was most different in epithelial ovarian cancer as compared to the normal fallopian tube. HPDL expression was significantly higher in high-grade serous ovarian tumors relative to normal fallopian tube. HPDL expression correlated with overall survival in patients with ovarian cancer. These data indicate that expression of HPDL is perturbed in epithelial ovarian cancers broadly and in ovarian cancers of the HGSC subtype. HPDL may be relevant to pathways underlying ovarian cancer initiation (transformation) or progression.

scholarly journals Differential expression of ADAMTS-like 3 in human epithelial ovarian cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Fallopian Tube ◽  
Expression Profiles ◽  
Gynecologic Cancer ◽  
Gene Expression Profiles ◽  
Global Gene Expression ◽  
High Grade ◽  
Primary Tumors ◽  
Ovarian Cancers

Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer (1). We performed discovery of genes associated with epithelial ovarian cancer and of the high-grade serous ovarian cancer (HGSC) subtype, using published and public microarray data (2, 3) to compare global gene expression profiles of normal ovary or fallopian tube with that of primary tumors from women diagnosed with epithelial ovarian cancer or HGSC. We identified the gene encoding ADAMTS-like 3, ADAMTSL3, as among the genes whose expression was most different in epithelial ovarian cancer as compared to the normal fallopian tube. ADAMTSL3 expression was significantly lower in high-grade serous ovarian tumors relative to normal fallopian tube. ADAMTSL3 expression correlated with overall survival in patients with ovarian cancer. These data indicate that expression of ADAMTSL3 is perturbed in epithelial ovarian cancers broadly and in ovarian cancers of the HGSC subtype. ADAMTSL3 may be relevant to pathways underlying ovarian cancer initiation (transformation) or progression.

scholarly journals Differential expression of MAM domain-containing 2 in human epithelial ovarian cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Fallopian Tube ◽  
Expression Profiles ◽  
Gynecologic Cancer ◽  
Gene Expression Profiles ◽  
Global Gene Expression ◽  
High Grade ◽  
Primary Tumors ◽  
Ovarian Cancers

Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer (1). We performed discovery of genes associated with epithelial ovarian cancer and of the high-grade serous ovarian cancer (HGSC) subtype, using published microarray data (2, 3) to compare global gene expression profiles of normal ovary or fallopian tube with that of primary tumors from women diagnosed with epithelial ovarian cancer or HGSC. We identified the gene encoding MAM domain-containing 2, MAMDC2, as among the genes whose expression was most different in epithelial ovarian cancer as compared to the normal fallopian tube. MAMDC2 expression was significantly lower in high-grade serous ovarian tumors relative to normal fallopian tube. MAMDC2 expression correlated with overall survival in patients with ovarian cancer. These data indicate that expression of MAMDC2 is perturbed in epithelial ovarian cancers broadly and in ovarian cancers of the HGSC subtype. MAMDC2 may be relevant to pathways underlying ovarian cancer initiation (transformation) or progression.

scholarly journals Differential expression of neuromedin U in human epithelial ovarian cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Fallopian Tube ◽  
Expression Profiles ◽  
Gynecologic Cancer ◽  
Gene Expression Profiles ◽  
Global Gene Expression ◽  
High Grade ◽  
Primary Tumors ◽  
Ovarian Cancers

Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer (1). We performed discovery of genes associated with epithelial ovarian cancer and of the high-grade serous ovarian cancer (HGSC) subtype, using published microarray data (2, 3) to compare global gene expression profiles of normal ovary or fallopian tube with that of primary tumors from women diagnosed with epithelial ovarian cancer or HGSC. We identified the gene encoding neuromedin U, NMU, as among the genes whose expression was most different in epithelial ovarian cancer as compared to the normal fallopian tube. NMU expression was significantly higher in high-grade serous ovarian tumors relative to normal fallopian tube. NMU expression correlated with overall survival in patients with ovarian cancer. These data indicate that expression of NMU is perturbed in epithelial ovarian cancers broadly and in ovarian cancers of the HGSC subtype. NMU may be relevant to pathways underlying ovarian cancer initiation (transformation) or progression.

scholarly journals Differential expression of synuclein alpha in human epithelial ovarian cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Fallopian Tube ◽  
Expression Profiles ◽  
Gynecologic Cancer ◽  
Gene Expression Profiles ◽  
Global Gene Expression ◽  
High Grade ◽  
Primary Tumors ◽  
Ovarian Cancers

Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer (1). We performed discovery of genes associated with epithelial ovarian cancer and of the high-grade serous ovarian cancer (HGSC) subtype, using published microarray data (2, 3) to compare global gene expression profiles of normal ovary or fallopian tube with that of primary tumors from women diagnosed with epithelial ovarian cancer or HGSC. We identified the gene encoding synuclein alpha, SNCA, as among the genes whose expression was most different in epithelial ovarian cancer as compared to the normal fallopian tube. SNCA expression was significantly lower in high-grade serous ovarian tumors relative to normal fallopian tube. SNCA expression correlated with overall survival in patients with ovarian cancer. These data indicate that expression of SNCA is perturbed in epithelial ovarian cancers broadly and in ovarian cancers of the HGSC subtype. SNCA may be relevant to pathways underlying ovarian cancer initiation (transformation) or progression.

scholarly journals Differential expression of ribophorin II in human epithelial ovarian cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Fallopian Tube ◽  
Expression Profiles ◽  
Gynecologic Cancer ◽  
Gene Expression Profiles ◽  
Global Gene Expression ◽  
High Grade ◽  
Primary Tumors ◽  
Ovarian Cancers

Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer (1). We performed discovery of genes associated with epithelial ovarian cancer and of the high-grade serous ovarian cancer (HGSC) subtype, using published microarray data (2, 3) to compare global gene expression profiles of normal ovary or fallopian tube with that of primary tumors from women diagnosed with epithelial ovarian cancer or HGSC. We identified the gene encoding ribophorin II, RPN2, as among the genes whose expression was most different in epithelial ovarian cancer as compared to the normal fallopian tube. RPN2 expression was significantly higher in high-grade serous ovarian tumors relative to normal fallopian tube. These data indicate that expression of RPN2 is perturbed in epithelial ovarian cancers broadly and in ovarian cancers of the HGSC subtype. RPN2 may be relevant to pathways underlying ovarian cancer initiation (transformation) or progression.

scholarly journals Differential expression of NK2 homeobox 1 in human epithelial ovarian cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Fallopian Tube ◽  
Expression Profiles ◽  
Gynecologic Cancer ◽  
Gene Expression Profiles ◽  
Global Gene Expression ◽  
High Grade ◽  
Primary Tumors ◽  
Ovarian Cancers

Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer (1). We performed discovery of genes associated with epithelial ovarian cancer and of the high-grade serous ovarian cancer (HGSC) subtype, using published and public microarray data (2, 3) to compare global gene expression profiles of normal ovary or fallopian tube with that of primary tumors from women diagnosed with epithelial ovarian cancer or HGSC. We identified the gene encoding NK2 homeobox 1, NKX2-1, as among the genes whose expression was most different in epithelial ovarian cancer as compared to the normal fallopian tube. NKX2-1 expression was significantly lower in high-grade serous ovarian tumors relative to normal fallopian tube. NKX2-1 expression correlated with overall survival in patients with ovarian cancer. These data indicate that expression of NKX2-1 is perturbed in epithelial ovarian cancers broadly and in ovarian cancers of the HGSC subtype. NKX2-1 may be relevant to pathways underlying ovarian cancer initiation (transformation) or progression.

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