scholarly journals Over-expression of centromere protein F in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Over Expression ◽  
Centromere Protein ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Protein F ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified centromere protein F, encoded by CENPF, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. CENPF was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, primary tumor expression of CENPF was correlated with overall survival in patients with endometrial cancer. CENPF may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of cytoskeleton associated protein 2 in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Mutational Burden ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified cytoskeleton associated protein 2, encoded by CKAP2, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. CKAP2 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of CKAP2 was correlated with recurrence-free survival in white patients with high and low mutational burden. CKAP2 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of insulin degrading enzyme in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Insulin Degrading Enzyme ◽  
Normal Endometrium ◽  
Degrading Enzyme ◽  
Over Expression ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified the insulin degrading enzyme, encoded by IDE, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. IDE was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, primary tumor expression of IDE was correlated with overall survival in patients with endometrial cancer. IDE may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of structural maintenance of chromosomes 4 in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Microarray Data ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Over Expression ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression ◽  
Structural Maintenance Of Chromosomes

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified structural maintenance of chromosomes 4, encoded by SMC4, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. SMC4 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, primary tumor expression of SMC4 was correlated with overall survival in patients with endometrial cancer. SMC4 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of ZW10 interacting kinetochore protein in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Microarray Data ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Kinetochore Protein ◽  
Over Expression ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified ZW10 interacting kinetochore protein, encoded by ZWINT, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. ZWINT was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, primary tumor expression of ZWINT was correlated with overall survival in patients with endometrial cancer. ZWINT may be a molecule of interest in understanding the etiology and/or progression of human endometrial cancer.

scholarly journals Over-expression of cyclin B1 in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Cell Cycle ◽  
Endometrial Cancer ◽  
Clinical Problem ◽  
Cyclin B1 ◽  
Normal Endometrium ◽  
Over Expression ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1, 2, 3, 4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified the cell cycle component cyclin B1, encoded by CCNB1, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. CCNB1 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, high primary tumor expression of CCNB1 was correlated with worse overall survival in patients with endometrial cancer. Together, the data reveal over-expression of CCNB1 in human endometrial cancer and describe specific activation of the cell cycle in cancers of the endometrium.

scholarly journals Over-expression of CDK1 in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Cell Cycle ◽  
Endometrial Cancer ◽  
Clinical Problem ◽  
Cyclin Dependent Kinase ◽  
Normal Endometrium ◽  
Over Expression ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1, 2, 3, 4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified the cell cycle component cyclin-dependent kinase 1, encoded by CDK1, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. CDK1 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, high primary tumor expression of CDK1 was correlated with worse overall survival in patients with endometrial cancer. Together, the data reveal over-expression of CDK1 in human endometrial cancer and describe specific activation of the cell cycle in cancers of the endometrium.

scholarly journals Over-expression of tubulin beta 4B class IVb in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Overall Survival ◽  
Endometrial Cancer ◽  
Microarray Data ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Over Expression ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified tubulin beta 4B class IVb, encoded by TUBB4B, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. TUBB4B was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, primary tumor expression of TUBB4B was correlated with overall survival in patients with endometrial cancer. TUBB4B may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of adenosine kinase in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Microarray Data ◽  
Clinical Problem ◽  
Adenosine Kinase ◽  
Normal Endometrium ◽  
Over Expression ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified adenosine kinase, encoded by ADK, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. ADK was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, primary tumor expression of ADK was correlated with overall survival in patients with endometrial cancer. ADK may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of CDC20 in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Endometrial Cell ◽  
Normal Endometrium ◽  
Over Expression ◽  
Mutational Burden ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified cell division cycle 20, encoded by CDC20, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. CDC20 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, high primary tumor expression of CDC20 was correlated with worse overall survival in white endometrial cancer patients with high mutational burden. The data allude to activation of the endometrial cell cycle in patients with endometrial cancer.

scholarly journals Over-expression of KIAA0101 (PCLAF) in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Microarray Data ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified KIAA0101, also known as the PCNA clamp-associated factor (PCLAF) as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. KIAA0101 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, primary tumor expression of KIAA0101 was correlated with recurrence-free survival in patients with endometrial cancer. KIAA0101 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

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