STAT4 expression associates with survival in triple negative breast cancer.
We mined published microarray data (1) to understand the most significant gene expression differences in the tumors of triple negative breast cancer patients based on survival at time of analysis: dead or alive. We observed significant transcriptome-wide differential expression of signal transducer and activator of transcription 4, encoded by STAT4 when comparing the primary tumors of triple negative breast cancer patients dead or alive. Importantly, STAT4 expression was significantly correlated with overall survival in basal subtype breast cancer, a molecular subtype sharing significant overlap with triple negative breast cancer. STAT4 may be of relevance as a biomarker or as a molecule of interest in understanding the etiology or progression of triple negative breast cancer.